Carfilzomib

KYPROLIS®

Overview

Carfilzomib is a cancer medicine that interferes with the growth and spread of cancer cells in the body. It is approved for use with lenalidomide and dexamethasone for the treatment of relapsed multiple myeloma in patients who have received one to three prior lines of therapy. Carfilzomib is injected into a vein through an IV.

SparkCures ID 2
Developed By Amgen
Brand Name Kyprolis®
Generic Name Carfilzomib
Additional Names PR-171
Treatment Classifications
Tags
  • FDA Approved

Clinical Trials

All Clinical Trials

View all active clinical trials around the US.

Verified
A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapse...
SUCCESSOR-2
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Verified
Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide and Dexamethasone (KRd vs. VRd) in Patients With Newly Diagnosed Multiple Myelom...
COBRA
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Verified
A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma (ADVANCE)
ADVANCE
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Verified
KRDI in Transplant-Eligible MM
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Verified
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM
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Verified
Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma
NEWLY DIAGNOSED DKRD
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Verified
Phase 2 Clinical Trial Evaluating the Safety, Tolerability, and Effectiveness of Venetoclax combined with Carfilzomib and Dexamethasone in Relapsed/Refractor...
VENETOCLAX
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Verified
Multicenter, Open-label, Single-arm, Phase 1b/2 Study of the Safety and Efficacy of Combination Treatment With Pomalidomide, Dexamethasone, and Carfilzomib (...
View Trial
Verified
A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in...
CC-92480
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Verified
Phase 1a/1b Dose Escalation and Expansion Trial of TTI-622 in Patients with Advanced Hematologic Malignancies, Including Lymphoma, Leukemia, and Multiple Mye...
TTI-622
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Verified
A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants Wi...
IBERDOMIDE
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SparkCures Verified Accurate, up-to-date information. Learn more

Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multip...
View Trial
Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma
View Trial
A Phase 2 Adaptive Study of Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in P...
View Trial
Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma
View Trial
Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refracto...
View Trial
A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multipl...
SELINEXOR
View Trial
Study of Magrolimab Combinations in Participants With Relapsed/Refractory Multiple Myeloma
MAGROLIMAB
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Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial
REACH
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A Clinical Trial of Three Medicines (Elranatamab Plus Carfilzomib and Dexamethasone) in People With Relapse...
MAGNETISMM-20
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A Phase 1b/2 Study of BGB-11417 in Monotherapy and in Various Combinations With Dexamethasone and Carfilzom...
BGB-11417
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COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide (COMMANDER)
COMMANDER
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A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma
IINNOVATE-2
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Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma
CC-220
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A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma
MONUMENTAL-2
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Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
BELANTAMAB MAFODOTIN
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Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With R...
SCOPE
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Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma (CarMob)
CARMOB
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Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multipl...
ISATUXIMAB
View Trial
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma
View Trial
Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
SELINEXOR
View Trial
Untreated / Newly Diagnosed Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment.

Verified
Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide and Dexamethasone (KRd vs. VRd) in Patients With Newly Diagnosed Multiple Myelom...
COBRA
View Trial
Verified
A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma (ADVANCE)
ADVANCE
View Trial
Verified
KRDI in Transplant-Eligible MM
View Trial
Verified
Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma
NEWLY DIAGNOSED DKRD
View Trial
Verified
A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in...
CC-92480
View Trial

SparkCures Verified Accurate, up-to-date information. Learn more

Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial
REACH
View Trial
Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
BELANTAMAB MAFODOTIN
View Trial
Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma (CarMob)
CARMOB
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Early Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.

Verified
A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapse...
SUCCESSOR-2
View Trial
Verified
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM
View Trial
Verified
Phase 2 Clinical Trial Evaluating the Safety, Tolerability, and Effectiveness of Venetoclax combined with Carfilzomib and Dexamethasone in Relapsed/Refractor...
VENETOCLAX
View Trial
Verified
Multicenter, Open-label, Single-arm, Phase 1b/2 Study of the Safety and Efficacy of Combination Treatment With Pomalidomide, Dexamethasone, and Carfilzomib (...
View Trial
Verified
A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in...
CC-92480
View Trial
Verified
A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants Wi...
IBERDOMIDE
View Trial

SparkCures Verified Accurate, up-to-date information. Learn more

Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multip...
View Trial
Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma
View Trial
Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma
View Trial
Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refracto...
View Trial
A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multipl...
SELINEXOR
View Trial
Study of Magrolimab Combinations in Participants With Relapsed/Refractory Multiple Myeloma
MAGROLIMAB
View Trial
A Clinical Trial of Three Medicines (Elranatamab Plus Carfilzomib and Dexamethasone) in People With Relapse...
MAGNETISMM-20
View Trial
A Phase 1b/2 Study of BGB-11417 in Monotherapy and in Various Combinations With Dexamethasone and Carfilzom...
BGB-11417
View Trial
A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma
IINNOVATE-2
View Trial
Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
BELANTAMAB MAFODOTIN
View Trial
Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With R...
SCOPE
View Trial
Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma (CarMob)
CARMOB
View Trial
Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multipl...
ISATUXIMAB
View Trial
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma
View Trial
Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
SELINEXOR
View Trial
Late Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.

Verified
A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapse...
SUCCESSOR-2
View Trial
Verified
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM
View Trial
Verified
Phase 2 Clinical Trial Evaluating the Safety, Tolerability, and Effectiveness of Venetoclax combined with Carfilzomib and Dexamethasone in Relapsed/Refractor...
VENETOCLAX
View Trial
Verified
Multicenter, Open-label, Single-arm, Phase 1b/2 Study of the Safety and Efficacy of Combination Treatment With Pomalidomide, Dexamethasone, and Carfilzomib (...
View Trial
Verified
A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in...
CC-92480
View Trial
Verified
Phase 1a/1b Dose Escalation and Expansion Trial of TTI-622 in Patients with Advanced Hematologic Malignancies, Including Lymphoma, Leukemia, and Multiple Mye...
TTI-622
View Trial
Verified
A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants Wi...
IBERDOMIDE
View Trial

SparkCures Verified Accurate, up-to-date information. Learn more

Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multip...
View Trial
Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma
View Trial
Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma
View Trial
Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refracto...
View Trial
A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multipl...
SELINEXOR
View Trial
Study of Magrolimab Combinations in Participants With Relapsed/Refractory Multiple Myeloma
MAGROLIMAB
View Trial
A Clinical Trial of Three Medicines (Elranatamab Plus Carfilzomib and Dexamethasone) in People With Relapse...
MAGNETISMM-20
View Trial
A Phase 1b/2 Study of BGB-11417 in Monotherapy and in Various Combinations With Dexamethasone and Carfilzom...
BGB-11417
View Trial
A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma
IINNOVATE-2
View Trial
Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
BELANTAMAB MAFODOTIN
View Trial
Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With R...
SCOPE
View Trial
Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multipl...
ISATUXIMAB
View Trial
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma
View Trial
Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
SELINEXOR
View Trial
Smoldering Myeloma

The following is a listing of clinical trials for patients with Smoldering Myeloma.

A Phase 2 Adaptive Study of Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in P...
View Trial
Monoclonal Gammopathy of Undetermined Significance (MGUS)

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