Phase 3 Clinical Trial Comparing the Safety and Efficacy of BMS-986393 to Standard of Care Regimens in Patients with Relapsed/Refractory Multiple Myeloma QUINTESSENTIAL-2
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What's the purpose of this trial?

The goal of this clinical trial is to compare the efficacy of treatment with BMS-986393 to treatment with standard of care therapies in patients with relapsed/refractory multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

This trial is seeking approximately 440 participants. Participants will be randomized into one of two groups (or arms). Participants in Arm A will receive treatment with a GPRC5D Car T-Cell therapy, BMS-986393. Participants in Arm B will receive one of two standard of care regimens, Daratumumab + Pomalidomide + Dexamethasone or Carfilzomib + Dexamethasone. This trial is open-label, which means that both researchers and participants will know which arms they are placed in, and which therapies they will be receiving.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have measurable disease as defined by the trial criteria.
  • have previously received 1-3 prior lines of therapy, which may have included a proteasome inhibitor, immunomodulatory agent, and an anti-CD38 monoclonal antibody.
  • have previously received and are refractory to Lenalidomide.
  • do not have central nervous system involvement of your myeloma.
  • have not previously received treatment with a GPRC5D targeting therapy.

Additional Trial Information

Phase 3

Enrollment: 440 patients (estimated)

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Trial Locations

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California

UCLA Medical Center, Santa Monica UCLA Health

Santa Monica, CA

Open and Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Open and Accepting
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