Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Elranatamab Versus Commonly Used Combination Regimens in Participants with Relapsed/Refractory Multiple Myeloma MAGNETISMM-32
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What's the purpose of this trial?

The goal of this clinical trial is to compare the safety and effectiveness of Elranatamab versus commonly used combination regimens in participants with relapsed/refractory multiple myeloma. 

This trial is currently open and accepting patients.

What will happen during the trial?

Participants will be randomly assigned into either the experimental group (receiving elranatamab) or the comparator group (receiving one of three commonly used combination treatment regimens that will be selected by the study doctor). This study is open-label, which means that both researchers and participants will know which groups the participants have been placed in, and which treatments they will be receiving. Participants may continue to receive treatment as long as they don’t experience unacceptable side effects and their myeloma doesn’t get worse.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have multiple myeloma that has worsened or not responded to last line of therapy.
  • have received between 1-4 prior lines of therapy which includes:
    • at least 2 consecutive cycles of an anti-CD38 antibody, and
    • at least 2 consecutive cycles of lenalidomide.
  • have not previously received treatment with a BCMA or CD3 targeted therapy.
  • are eligible to receive at least one of the comparator regimens of the study.
  • have adequate cardiac, liver and kidney function.

Additional eligibility criteria apply and can be explained by the study doctor. 

Additional Trial Information

Phase 3

Enrollment: 492 patients (estimated)

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Trial Links

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Trial Locations

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California

Beverly Hills Cancer Center

Beverly Hills, CA

Open and Accepting

Colorado

University of Colorado Health - Harmony

Fort Collins, CO

Open and Accepting
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