This is a phase I dose escalation and expansion study in RMM and RRMM followed by a single arm phase II expansion in high risk, NDMM. The phase I portion of the protocol will utilize a standard 3+3 dose escalation design to determine the maximum tolerated dose (MTD) and RP2D of the KRd-belantamab mafodotin combination. The phase II portion of the trial is a two-stage design that will assess the efficacy and safety of the combination in newly diagnosed, high-risk MM patients.
This trial is currently open and accepting patients.
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.
INCLUSION CRITERIA for all subjects:
Refrain from donating sperm
INCLUSION CRITERIA - Phase I treatment for Relapsed or Relapsed/Refractory MM:
Subjects with Relapsed or Relapsed/Refractory MM who have had 1-3 lines of prior therapy.
EXCLUSION CRITERIA for all subjects:
Enrollment: 70 patients (estimated)View More
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