Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma

What's the purpose of this trial?

This is a phase I dose escalation and expansion study in RMM and RRMM followed by a single arm phase II expansion in high risk, NDMM. The phase I portion of the protocol will utilize a standard 3+3 dose escalation design to determine the maximum tolerated dose (MTD) and RP2D of the KRd-belantamab mafodotin combination. The phase II portion of the trial is a two-stage design that will assess the efficacy and safety of the combination in newly diagnosed, high-risk MM patients.

This trial is currently open and accepting patients.

What will happen during the trial?

Additional Trial Information

Phase 1/2

Enrollment: 70 patients (estimated)

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Trial Locations

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North Carolina

Levine Cancer Institute Atrium Health

Charlotte, NC

Open and Accepting
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