Dana-Farber Cancer Institute Myeloma Trials

The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment.

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

PROMISE

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Verified

A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

DENOSUMAB

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A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide ...

CARTITUDE-6

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Safety Study of Unlicensed, Investigational Cord Blood Units Manufactured by the National Cord Blood Program (NCBP) for Unrelated Transplantation

INVESTIGATIONAL CORD BLOOD UNITS

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Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

LOW-DOSE RADIOTHERAPY FOR BONE METASTASES

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Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in Newly Diagnosed Multiple Myeloma

ISATUXIMAB

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Autologous Memory-like NK Cell Therapy With BHV-1100 and Low Dose IL-2 in Multiple Myeloma Patients

NK CELL THERAPY WITH BHV-1100

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With ...

CORD BLOOD UNITS FOR NEUTROPHIL RECOVERY

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Early Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

PROMISE

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Verified

Phase 3 Clinical Trial Evaluating the Safety and Effectiveness of Investigational Drug Mezigdomide in Combination with Bortezomib and Dexamethasone Compared ...

SUCCESSOR-1

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Verified

Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Iberdomide, Daratumumab and Dexamethasone VS Daratumumab, Bortezomib, and Dexamethasone in P...

EXCALIBER RRMM

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Phase 3 Study Evaluating the Safety and Effectiveness of Investigational Drug Mezigdomide in Combination with Carfilzomib and Dexamethasone in Relapsed or Re...

SUCCESSOR-2

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Phase 1B / 2 Study of Selinexor in Combination With Other Treatments for Relapsed/Refractory and Newly Diagnosed Multiple Myeloma.

STOMP

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Verified

A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

DENOSUMAB

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Verified

Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

DARATUMUMAB COMBINATION THERAPY

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A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants With Relapsed an...

CA088-1005

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A Phase II Study of ISABELA: Isatuximab, Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Relapsed and Refractory Multiple Myeloma

ISABELA

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Safety Study of Unlicensed, Investigational Cord Blood Units Manufactured by the National Cord Blood Program (NCBP) for Unrelated Transplantation

INVESTIGATIONAL CORD BLOOD UNITS

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Study of Anitocabtagene-autoleucel in Relapsed or Refractory Multiple Myeloma

IMMAGINE-1

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Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

LOW-DOSE RADIOTHERAPY FOR BONE METASTASES

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Myeloma-Developing Regimens Using Genomics

MYDRUG

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Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory NHL, RT, MM, T-PLL, Acute Leukemia (AML, ALL), MDS, MDS/MPN, and MF

LP-118

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Ixazomib + Pomalidomide + Dexamethasone In Multiple Myeloma

IXAZOMIB COMBINATION THERAPY

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With ...

CORD BLOOD UNITS FOR NEUTROPHIL RECOVERY

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Supportive Transfusion Program for Patients With Hematologic Malignancies: A Cluster Randomized Trial

HEME HOSPICE - HOME TRANSFUSION PROGRAM

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Late Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

PROMISE

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Verified

Phase 3 Clinical Trial Evaluating the Safety and Effectiveness of Investigational Drug Mezigdomide in Combination with Bortezomib and Dexamethasone Compared ...

SUCCESSOR-1

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Verified

Phase 3 Study Evaluating the Safety and Effectiveness of Investigational Drug Mezigdomide in Combination with Carfilzomib and Dexamethasone in Relapsed or Re...

SUCCESSOR-2

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Verified

Phase 2 Study of BMS-986393, a GPRC5D-directed CART-Cell Therapy, in Participants with Relapsed or Refractory Multiple Myeloma

QUINTESSENTIAL

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Verified

Phase 1B / 2 Study of Selinexor in Combination With Other Treatments for Relapsed/Refractory and Newly Diagnosed Multiple Myeloma.

STOMP

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Verified

A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

DENOSUMAB

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Verified

Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

DARATUMUMAB COMBINATION THERAPY

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Verified

A Phase 1, Open-Label, Dose-Finding Study of BMS-986453, Dual Targeting BCMAxGPRC5D Chimeric Antigen Receptor T Cells, in Participants With Relapsed and/or R...

BMS-986453

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A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants With Relapsed an...

CA088-1005

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Verified

Platform Study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination with Anti-Cancer Treatments in Participants with Relapsed/Refractory Mu...

DREAMM5

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A Phase II Study of ISABELA: Isatuximab, Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Relapsed and Refractory Multiple Myeloma

ISABELA

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A Phase 2 Study of Elranatamab as Consolidation After Idecabtagene Vicleucel in Relapsed Refractory Multiple Myeloma

ELRANATAMAB AS CONSOLIDATION

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Safety Study of Unlicensed, Investigational Cord Blood Units Manufactured by the National Cord Blood Program (NCBP) for Unrelated Transplantation

INVESTIGATIONAL CORD BLOOD UNITS

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Study of Anitocabtagene-autoleucel in Relapsed or Refractory Multiple Myeloma

IMMAGINE-1

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Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

LOW-DOSE RADIOTHERAPY FOR BONE METASTASES

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A Phase 1b Trial of Teclistamab in Combination With Iberdomide for Relapsed/Refractory Multiple Myeloma

TECVAYLI

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Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

ELOTUZUMAB + IBERDOMIDE POST ABECMA

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A Phase 1b, Dose Escalation/Dose Expansion, Multicenter, Open-Label Study to Assess the Safety and Tolerability of OPN-6602 Monotherapy and in Combination Wi...

OPN-662

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Myeloma-Developing Regimens Using Genomics

MYDRUG

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Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma

CEMSIDOMIDE (CFT7455)

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Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory NHL, RT, MM, T-PLL, Acute Leukemia (AML, ALL), MDS, MDS/MPN, and MF

LP-118

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Ixazomib + Pomalidomide + Dexamethasone In Multiple Myeloma

IXAZOMIB COMBINATION THERAPY

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With ...

CORD BLOOD UNITS FOR NEUTROPHIL RECOVERY

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Supportive Transfusion Program for Patients With Hematologic Malignancies: A Cluster Randomized Trial

HEME HOSPICE - HOME TRANSFUSION PROGRAM

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Smoldering Myeloma

The following is a listing of clinical trials for patients with Smoldering Myeloma.

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

PROMISE

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CAR- PRISM (PRecision Intervention Smoldering Myeloma)

CAR-PRISM

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Phase 2 Dose-Ranging and Interception Study of Linvoseltamab in Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk S...

LINKER-MGUS1

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Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

IMMUNO-PRISM

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DARA RVD For High Risk SMM

PRISM

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Study of Precursor Hematological Malignancies to Assess the Relationship between Molecular Events of Progression and Clinical Outcome (PCROWD)

PCROWD

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Screening for AL Amyloidosis in Smoldering Multiple Myeloma

AMYLOIDOSIS SCREENING

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PROFAST Intervention in Precursor Multiple Myeloma

PROFAST

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Monoclonal Gammopathy of Undetermined Significance (MGUS)

The following is a listing of clinical trials for patients with Monoclonal Gammopathy of Undetermined Significance (MGUS).

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

PROMISE

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Phase 2 Dose-Ranging and Interception Study of Linvoseltamab in Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk S...

LINKER-MGUS1

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Study of Precursor Hematological Malignancies to Assess the Relationship between Molecular Events of Progression and Clinical Outcome (PCROWD)

PCROWD

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PROFAST Intervention in Precursor Multiple Myeloma

PROFAST

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