A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma and Determine the Recommended Dose for Each Add-on Investigational Component CA088-1005

What's the purpose of this trial?

The purpose of this study is to establish a safe and tolerable dose of BMS-986393 in combinations with alnuctamab, mezigdomide, and iberdomide in participants with relapsed and/or refractory multiple myeloma (RRMM).

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1 and Part 2) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2)
* Measurable multiple myeloma (MM)
* Eastern Cooperative Oncology Group performance status of 0-1

Exclusion Criteria:

* Condition that confounds the ability to interpret data from the study
* Known active or history of central nervous system (CNS) involvement of MM

Note: Other protocol-defined inclusion/exclusion criteria apply

Additional Trial Information

Phase 1

Enrollment: 111 patients (estimated)

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Trial Locations

All Trial Locations

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University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

Birmingham, AL

Open and Accepting


Mayo Clinic (Arizona)

Phoenix, AZ

Not Yet Accepting


City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting


Mayo Clinic (Jacksonville)

Jacksonville, FL

Not Yet Accepting


Northside Hospital (Atlanta)

Atlanta, GA

Open and Accepting


Beth Israel Deaconess Medical Center

Boston, MA

Not Yet Accepting

Dana-Farber Cancer Institute (Main)

Boston, MA

Not Yet Accepting


Mayo Clinic (Rochester)

Rochester, MN

Not Yet Accepting


New Jersey

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Montefiore Medical Center

Bronx, NY

Open and Accepting

Roswell Park Cancer Institute

Buffalo, NY

Not Yet Accepting

Perlmutter Cancer Center at NYU Langone Arena Oncology

North New Hyde Park, NY

Open and Accepting


Sarah Cannon Tennessee Oncology- Nashville (Hayes St.)

Nashville, TN

Not Yet Accepting


MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting
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