This is an open-label, multicenter, Phase 1/2 study to determine the maximum tolerated dose (MTD) / recommended phase 2 dose (RP2D), and to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.
SparkCures ID | 1079 |
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Trial Phase | Phase 1/2 |
Enrollment | 384 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Inclusion Criteria:
Exclusion Criteria:
The following is a listing of trial locations that are open and accepting patients.
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Tampa, FL
Chicago, IL
Boston, MA
Boston, MA
Boston, MA
Rochester, MN
Nashville, TN
Seattle, WA
Tampa, FL
Chicago, IL
Boston, MA
Boston, MA
Boston, MA
Rochester, MN
Nashville, TN
Seattle, WA
December 06, 2020
CC-92480, a novel oral cereblon E3 ligase modulator (CELMoD) agent, plus dexamethasone demonstrated immunomodulatory activity across all dose levels examined in patients with relapsed/refractory multiple myeloma, according to data from the first portion of the ongoing phase 1 CC-92480-MM-001 trial (NCT03374085) presented during the 2020 ASH Annual Meeting & Exposition.
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