The following criteria is provided for health care professionals.

Inclusion Criteria:

1. Subjects is ≥ 18 years of age and has an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2.
2. Relapsed or refractory subjects must have measurable disease and have documented disease progression during or after their last anti-myeloma regimen.
3. Newly diagnosed subjects must have documented diagnosis with previously untreated symptomatic multiple myeloma.
4. Females of childbearing potential (FCBP) and male subjects must agree with the pregnancy prevention plan.

Exclusion Criteria:

1. Subject has a significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study.
2. Subject is unable or unwilling to undergo protocol required thromboembolism prophylaxis.