Daratumumab is a type of cancer drug called a monoclonal antibody. Daratumumab attaches to a protein called CD38, which is present in high numbers on the surface of multiple myeloma cells, as well as on certain other types of cells, such as red blood cells.
SparkCures ID | 51 |
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Developed By | Janssen Research & Development LLC |
Brand Name | Darzalex® |
Generic Name | Daratumumab |
Additional Names | CD38 mAb, HuMax-CD38 |
Treatment Classifications | |
Treatment Targets |
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The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment.
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The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.
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The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.
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The following is a listing of clinical trials for patients with Smoldering Myeloma.
The following is a listing of clinical trials for patients with Monoclonal Gammopathy of Undetermined Significance (MGUS).
December 12, 2023
The PERSEUS study, conducted in collaboration with the European Myeloma Network, found that induction and consolidation treatment with DARZALEX FASPRO® in combination with bortezomib, lenalidomide and dexamethasone (D-VRd), followed by DARZALEX FASPRO® and lenalidomide (D-R) maintenance, reduced the risk of disease progression or death by 58 percent (Hazard Ratio [HR], 0.42; 95 percent Confidence Interval [CI] 0.30-0.59; P <0.0001), compared to bortezomib, lenalidomide and dexamethasone (VRd) alone followed by lenalidomide (R) maintenance.1 The quadruplet regimen also significantly increased the depth of response compared to treatment with VRd alone, with higher rates of CR or better, stringent complete response (sCR), and MRD negativity.
December 19, 2023
December 12, 2017
December 16, 2017