Daratumumab Myeloma Trials

Darzalex^® is not chemotherapy. Darzalex^® is a monoclonal antibody that works in several ways. One way this monoclonal antibody works is by attaching itself to multiple myeloma cells in your body and directly killing them, and/or allowing your immune system to destroy them.

Darzalex^® targets and attaches to a protein called CD38, which is present on the surface of certain types of cells (eg, red blood cells) and is also present in high numbers on multiple myeloma cells. Since Darzalex^® targets the CD38 protein, it may also affect other cells with this protein on their surface.

SparkCures ID	51
Developed By	Janssen Research & Development
Brand Name	Darzalex^®
Generic Name	Daratumumab
Additional Names	CD38 mAb, HuMax-CD38
Treatment Classifications	Monoclonal Antibody
Treatment Targets	CD38
Tags	FDA Approved Published Results

All Clinical Trials

View all active clinical trials around the US.

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A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratum...

MAJESTEC-3

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A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Min...

AURIGA

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Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Iberdomide, Daratumumab and Dexamethasone VS Daratumumab, Bortezomib, and Dexamethasone in P...

EXCALIBER

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Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/...

MAGNETISMM-5

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Phase 3 Clinical Trial Comparing the Efficacy of an Investigational Medication Combined with Daratumumab or Daratumumab and Pomalidomide Versus Daratumumab, ...

MONUMENTAL-3

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Multicenter, Open-label, Single-arm, Phase 1b/2 Study of the Safety and Efficacy of Combination Treatment With Pomalidomide, Dexamethasone, and Carfilzomib (...

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Daratumumab-Based Therapy for the Treatment of Newly Diagnosed Multiple Myeloma With Kidney Failure

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A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma (ADVANCE)

ADVANCE

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Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

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A Study of Health-Related Quality of Life in People With Multiple Myeloma Receiving Daratumumab or Lenalidomide

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Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma

NEWLY DIAGNOSED DKRD

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A Study of TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma

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FT576 in Subjects With Multiple Myeloma

FT576

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A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in...

CC-92480

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Phase 1b/2a Clinical Trial Studying the Safety and Optimal Dose of Iberdomide by Itself and in Combination with Other Approved Treatments in Multiple Myeloma

IBERDOMIDE

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A Study to Compare Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) in Participants Wi...

MAJESTEC-7

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Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering ...

DETER-SMM

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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duratio...

DRAMMATIC

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Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE ...

EQUATE

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Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refracto...

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A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myelo...

D-CLAPD

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DARA RVD For High Risk SMM

PRISM

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Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma

SELINEXOR

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A Phase 2 Adaptive Study of Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in P...

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Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma

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Reduce Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed Multiple Myeloma

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Study of Lenalidomide / Ixazomib / Dexamethasone / Daratumumab in Transplant-Ineligible Patients With Newly...

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Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

MILESTONE

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Study of Magrolimab Combinations in Participants With Relapsed/Refractory Multiple Myeloma

MAGROLIMAB

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Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma

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A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multip...

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Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial

REACH

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A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multipl...

SELINEXOR

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Adaptive Strategy in Treatment for Newly Diagnosed Multiple Myeloma With Upfront Daratumumab-based Therapy

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Daratumumab in Treating Participants With Relapsed Multiple Myeloma After Stem Cell Transplant

DARATUMUMAB

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Study of SubQ Dara With Dose-Attenuated Bortezomib, Lenalidomide, Dexamethasone in Elderly Newly Diagnosed ...

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Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating...

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Daratumumab After Stem Cell Transplant in Treating Patients With Multiple Myeloma

DARATUMUMAB AS CONSOLIDATION/MAINTENANCE

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A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma

IINNOVATE-2

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An Open-Label, Multicenter, Phase 1/2 Trial of GEN3014 (HexaBody®-CD38) in Relapsed or Refractory Multiple ...

GEN3014 (HEXABODY®-CD38)

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COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide (COMMANDER)

COMMANDER

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Home Based Daratumumab Administration for Patients With Multiple Myeloma

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A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma

IINNOVATE-3

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A Study Of TAK-981 Given With Monoclonal Antibodies In Adults With Relapsed or Refractory Multiple Myeloma

TAK-981

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Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multip...

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-383 in C...

ABBV-383

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A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma

MONUMENTAL-2

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APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple My...

APG-2575

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A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma

MAJESTEC-2

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Myeloma-Developing Regimens Using Genomics

MYDRUG

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Untreated / Newly Diagnosed Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment.

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