Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

DETER-SMM

Overview

This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.

SparkCures ID 999
Trial Phase Phase 3
Enrollment 288 Patients
Treatments
Tags
Trial Sponsors
  • Eastern Cooperative Oncology Group (ECOG)
Trial Collaborators
  • National Cancer Institute (NCI)
NCT Identifier

NCT03937635

ACCEPTING

This trial is currently open and accepting patients.

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Inclusion Criteria:

  • Patients must be diagnosed with asymptomatic high-risk smoldering multiple myeloma (SMM) within the past 12 months. High-risk is defined by any one of the following factors:
    • Abnormal serum free light chain ratio (≤ 0.125 or ≥ 8.0 and involved chain < 100 mg/L) by serum free light chain (FLC) assay
    • Serum M-protein level ≥ 3 gm/dL
    • Presence of t(4;14) or del 17p or 1q gain by conventional cytogenetics or fluorescence in situ hybridization (FISH) studies.
  • Bone marrow aspirate and/or biopsy is required to be performed within 28 days prior to randomization and must demonstrate 10-59% clonal plasma cells.
  • ≥ 1 g/dL on serum protein electrophoresis (within 28 days prior to randomization).
  • ≥ 200 mg of monoclonal protein on a 24 hour urine protein electrophoresis (within 28 days prior to randomization).
    • NOTE: In the rare situation where the serum protein electrophoresis (SPEP) is felt to be unreliable, then quantitative immunoglobulin levels on nephelometry or turbidometry can be accepted.
  • SPEP, urine protein electrophoresis (UPEP), and serum FLC are required to be performed within 28 days prior to randomization.
    • NOTE: UPEP (on a 24-hour collection) is required; no substitute method is acceptable. Urine must be followed monthly if the baseline urine M-spike is >= 200 mg/24 hour (hr), and urine in addition to serum must be followed in order to confirm a very good partial response (VGPR) or higher response.
  • Patients must have no lytic lesions, no known plasmacytoma, and no unexplained hypercalcemia (i.e., > 11 mg/dL or 1mg/dL above upper limit of normal [ULN]).
  • Hemoglobin >= 11 g/dL (within 28 days prior to randomization).
  • Platelet count >= 100,000 cells/mm^3 (within 28 days prior to randomization).
  • Absolute neutrophil count >= 1500 cells/mm^3 (within 28 days prior to randomization).
  • Calculated creatinine clearance >= 30 mL/min (within 28 days prior to randomization).
  • Bilirubin =< 1.5 mg/dL (within 28 days prior to randomization).
  • Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 times the upper limit of normal (within 28 days prior to randomization).
  • Patients must not have any prior or concurrent systemic or radiation therapy for the treatment of myeloma. Patients must also not have contraindication to deep vein thrombosis (DVT) prophylaxis/aspirin.
  • Patients must not have more than one focal marrow lesion on magnetic resonance imaging (MRI) of either pelvis or spine.
  • Concurrent use of erythropoietin is not allowed while on study therapy.
  • Prior or glucocorticosteroid therapy for the treatment of multiple myeloma is not permitted. Prior systemic glucocorticosteroid use for the treatment of non-malignant disorders is permitted; concurrent use after registration on the study should be restricted to the equivalent of prednisone 10 mg per day. Prior or concurrent topical or localized glucocorticosteroid therapy to treat non-malignant comorbid disorders is permitted.
  • Patients must not have active, uncontrolled seizure disorder. Patients must not have had a seizure in the last 6 months.
  • Patients must not have uncontrolled intercurrent illness including uncontrolled hypertension, symptomatic congestive heart failure, unstable angina, uncontrolled cardiac arrhythmia, uncontrolled psychiatric illness or social situation that would limit compliance with the study, or a prior history of Stevens Johnson syndrome.
  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2.
  • Patients with monoclonal gammopathy of undetermined significance are not eligible.
  • Patients must not have grade 2 or higher peripheral neuropathy per CTCAE.
  • Patients must not have active, uncontrolled infection.
  • Patients may have a history of current or previous deep vein thrombosis or pulmonary embolism but are required to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation.
  • Patients should not have New York Heart Association classification III or IV heart failure at baseline.
  • Patients with a history of prior malignancy are eligible provided they were treated with curative intent and have been free of disease for the time period considered appropriate for cure of the specific cancer. For most diseases this time frame is 5 years.
  • Patients must agree to register into the mandatory Risk Evaluation and Mitigation Strategy (REMS) program and be willing and able to comply with the requirements of REMS.
  • Women must not be pregnant due to potential harm to the fetus from daratumumab and lenalidomide. All females of childbearing potential (FCBP) must have a blood test or urine study with a sensitivity of at least 25 mIU/mL within 10-14 days prior to the first dose of lenalidomide and again within 24 hours prior to the first dose of lenalidomide. FCBP must also agree to ongoing pregnancy testing while on treatment. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
  • Females of childbearing potential (FCBP) must either abstain from sexual intercourse for the duration of their participation in the study or agree to use TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME for 1) at least 28 days before starting study treatment; 2) while participating in the study; 3) during dose interruptions; and 4) for at least 28 days after the last dose of protocol treatment (FCBP who are assigned to Arm A and receive daratumumab must extend this contraception requirement to 3 months after the last dose of protocol treatment). Women must also agree to not breastfeed during this same time period. Men must agree to either abstain from sexual intercourse for the duration of their participation in the study or use a latex condom during sexual contact with a FCBP while participating in the study and for 28 days after the last dose of protocol treatment even if they have had a successful vasectomy. Men must also agree to abstain from donating sperm while on study treatment and for 28 days after the last dose of protocol treatment even if they have had a successful vasectomy. Both women and men must both agree to abstain from donating blood during study participation and for at least 28 days after the last dose of protocol treatment.
  • Human immunodeficiency virus (HIV)+ patients with undetectable HIV viral loads tested within 6 months are eligible.
  • Patients should not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to daratumumab, lenalidomide, or dexamethasone.
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US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

Verified Winship Cancer Institute of Emory University
Winship Cancer Institute of Emory University

Atlanta, GA

Verified Alvin J. Siteman Cancer Center Washington University Medical Campus
Alvin J. Siteman Cancer Center Washington University Medical Campus

St. Louis, MO

Verified UNC Lineberger Comprehensive Cancer Center University of North Carolina
UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Verified UW Carbone Cancer Center University of Wisconsin Health
UW Carbone Cancer Center University of Wisconsin Health

Madison, WI

SparkCures Verified Accurate, up-to-date information. Learn more

Anchorage Oncology Centre

Anchorage, AK

Alaska Breast Care and Surgery LLC

Anchorage, AK

Alaska Women's Cancer Care

Anchorage, AK

Katmai Oncology Group

Anchorage, AK

Providence Alaska Medical Center

Anchorage, AK

Alta Bates Summit Medical Center - Alta Bates Campus

Berkeley, CA

Providence Saint Joseph Medical Center

Burbank, CA

Moores Cancer Center UC San Diego Health

La Jolla, CA

Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

Rocky Mountain Cancer Centers (Aurora) Aurora

Aurora, CO

The Medical Center of Aurora (HealthONE)

Aurora, CO

Boulder Community Hospital

Boulder, CO

Rocky Mountain Cancer Center Boulder

Boulder, CO

Littleton Adventist Hospital

Centennial, CO

Centura Penrose Hospital

Colorado Springs, CO

Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

Porter Adventist Hospital

Denver, CO

HealthOne Presbyterian / St. Luke's Medical Center

Denver, CO

HealthOne Swedish Medical Center

Englewood, CO

North Colorado Medical Center

Greeley, CO

Centura St. Anthony Hospital

Lakewood, CO

Mountain Blue Cancer Care Center

Lakewood, CO

Rocky Mountain Cancer Center Littleton

Littleton, CO

HealthOne Sky Ridge Medical Center

Lone Tree, CO

Centura Longmont United Hospital

Longmont, CO

Rocky Mountain Cancer Centers (Longmont) Longmont

Longmont, CO

McKee Medical Center

Loveland, CO

Centura Parker Adventist Hospital

Parker, CO

Saint Mary Corwin Medical Center

Pueblo, CO

Rocky Mountain Cancer Center - Thornton

Thornton, CO

Yale Cancer Center - Smilow Cancer Hospital Care Center Fairfield

Fairfield, CT

Smilow Cancer Hospital - Shoreline Medical Center Yale New Haven Health

Guilford, CT

Smilow Cancer Hospital at Saint Francis Hospital Trinity Health of New England

Hartford, CT

Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven

New Haven, CT

Yale-New Haven Hospital - North Haven Medical Center

North Haven, CT

Smilow Cancer Hospital Care Center (Orange)

Orange, CT

Smilow Cancer Hospital Care Center (Trumbull)

Trumbull, CT

Smilow Cancer Hospital - The Harold Leever Regional Cancer Center (Waterbury)

Waterbury, CT

Holy Cross Hospital Holy Cross Health, A Member of Trinity Health

Fort Lauderdale, FL

Cleveland Clinic Florida

Weston, FL

St. Joseph's/Candler Health System

Savannah, GA

Mary Greeley Medical Center

Ames, IA

McFarland Clinic PC

Ames, IA

McFarland Clinic PC (Boone)

Boone, IA

MercyOne Clive Cancer Center

Clive, IA

Mission Cancer & Blood (Clive) In Clive Cancer Center

Clive, IA

Greater Regional Medical Center

Creston, IA

Medical Oncology and Hematology Associates (Des Moines) in UnityPoint Health - John Stoddard Cancer Center

Des Moines, IA

Broadlawns Medical Center

Des Moines, IA

Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

MercyOne Des Moines Medical Center

Des Moines, IA

MercyOne West Des Moines Medical Center

West Des Moines, IA

UnityPoint Health - Methodist West Hospital

West Des Moines, IA

St. Luke's Cancer Institute - Boise

Boise, ID

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

St. Luke's Cancer Institute (Meridian)

Meridian, ID

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Kootenai Cancer Center

Post Falls, ID

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Rush - Copley Medical Center

Aurora, IL

Carle Foundation Hospital (Vermilion)

Danville, IL

Carle (Effingham)

Effingham, IL

NorthShore University Health System - Evanston Hospital

Evanston, IL

Northwestern Medicine Cancer Center Delnor

Geneva, IL

UChicago Medicine Ingalls Memorial

Harvey, IL

Carle Foundation Hospital (Mattoon)

Mattoon, IL

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Good Samaritan Regional Health Center

Mount Vernon, IL

Illinois Cancer Specialists

Niles, IL

Carle Cancer Institute

Urbana, IL

Northwestern Medicine Cancer Center Warrenville

Warrenville, IL

Indiana University Health Hematology & Oncology (North Hospital) IU Health North Hospital Medical Office Building

Carmel, IN

Cotton O’Neil Cancer Center Stormont Vail Health

Topeka, KS

Saint Joseph Hospital East

Lexington, KY

U of L Health - Jewish Hospital

Louisville, KY

Jewish Hospital Medical Center Northeast

Louisville, KY

U of L Health - Brown Cancer Center University of Louisville

Louisville, KY

LSU Health Baton Rouge (North Clinic)

Baton Rouge, LA

Ochsner Medical Center

Jefferson, LA

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Tufts Medical Center Cancer Center

Boston, MA

Ascension Saint Agnes Hospital Saint Agnes Healthcare

Baltimore, MD

ProMedica Hickman Cancer Center Grace Christman Medical Building

Adrian, MI

Bronson Battle Creek Cancer Care Center

Battle Creek, MI

St. Joseph Mercy Brighton Health Center

Brighton, MI

St. Joseph Mercy Canton Health Center

Canton, MI

Caro Cancer Center

Caro, MI

St. Joseph Mercy Chelsea Hospital

Chelsea, MI

Henry Ford Medical Center (Fairlane)

Dearborn, MI

Henry Ford Hospital

Detroit, MI

Genesys Hurley Cancer Institute

Flint, MI

Hurley Medical Center

Flint, MI

Helen DeVos Children's Hospital

Grand Rapids, MI

Mercy Health Saint Mary's

Grand Rapids, MI

Spectrum Health

Grand Rapids, MI

Allegiance Health

Jackson, MI

Bronson Methodist Hospital

Kalamazoo, MI

West Michigan Cancer Center

Kalamazoo, MI

Borgess Medical Center

Kalamazoo, MI

Sparrow Hospital

Lansing, MI

St. Mary Mercy Hospital St. Joe's Health

Livonia, MI

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, MI

Mercy Health Mercy Campus

Muskegon, MI

Lakeland Community Hospital

Niles, MI

Henry Ford Medical Center (Columbus)

Novi, MI

St. Joseph Mercy (Oakland)

Pontiac, MI

Spectrum Health Reed City Hospital

Reed City, MI

Saint Mary's of Michigan

Saginaw, MI

Oncology Hematology Associates of Saginaw Valley PC

Saginaw Valley, MI

Spectrum Health Lakeland Medical Center

St. Joseph, MI

Spectrum Health Marie Yeager Cancer Center

St. Joseph, MI

Ascension Saint Joseph Hospital

Tawas City, MI

Munson Medical Center

Traverse City, MI

Ascension Macomb-Oakland Hospital - Webber Cancer Center

Warren, MI

Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

St. Joseph Mercy Ann Arbor Hospital

Ypsilanti, MI

Essentia Health Saint Joseph's Medical Center

Brainerd, MN

M Health Fairview Ridges Hospital

Burnsville, MN

Mercy Hospital

Coon Rapids, MN

Essentia Health

Deer River, MN

Essentia Health Saint Mary's Medical Center

Duluth, MN

Essentia Health (Miller-Dwan Building)

Duluth, MN

Fairview Southdale Hospital

Edina, MN

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Unity Hospital

Fridley, MN

Essentia Health Hibbing Clinic

Hibbing, MN

Fairview Maple Grove Medical Center

Maple Grove, MN

Minnesota Oncology Maplewood Cancer Center

Maplewood, MN

M Health Fairview St. John's Hospital

Maplewood, MN

Abbott-Northwestern Hospital Allina Health

Minneapolis, MN

Hennepin County Medical Center

Minneapolis, MN

Health Partners Inc.

Minneapolis, MN

Monticello Cancer Center

Monticello, MN

North Memorial Medical Health Center

Robbinsdale, MN

Mayo Clinic (Rochester)

Rochester, MN

Saint Francis Regional Medical Center

Shakopee, MN

Park Nicollet Specialty Center at Methodist Hospital

St. Louis Park, MN

Regions Hospital

St. Paul, MN

United Hospital

St. Paul, MN

Lakeview Hospital

Stillwater, MN

Essentia Health Virginia Clinic

Virginia, MN

Ridgeview Medical Center

Waconia, MN

Rice Memorial Hospital

Willmar, MN

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Saint Louis Cancer and Breast Institute

Ballwin, MO

Central Care Cancer Center

Bolivar, MO

Siteman Cancer Center at Barnes-Jewish West County Hospital

Creve Coeur, MO

Freeman Cornell-Beshore Cancer Institute

Joplin, MO

Saint Luke's Hospital of Kansas City

Kansas City, MO

Saint Luke's East (Lee's Summit)

Lees Summit, MO

Mercy Clinic Cancer and Hematology (Rolla)

Rolla, MO

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Mercy Hospital Springfield

Springfield, MO

CoxHealth South Hospital Cox Medical Center South

Springfield, MO

Heartland Regional Medical Center

St. Joseph, MO

Siteman Cancer Center (South St. Louis County)

St. Louis, MO

Mercy Hospital South

St. Louis, MO

Billings Clinic Cancer Center

Billings, MT

Bozeman Deaconess Hospital

Bozeman, MT

Benefis Sletten Cancer Institute

Great Falls, MT

Great Falls Clinic Specialty Center

Great Falls, MT

Kalispell Regional Medical Center

Kalispell, MT

Community Medical Hospital

Missoula, MT

Levine Cancer Institute Atrium Health

Charlotte, NC

Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

CHI Health St. Francis

Grand Island, NE

CHI Health Good Samaritan Hospital

Kearney, NE

CHI Health Creighton University Medical Center

Omaha, NE

Morristown Medical Center Atlantic Health System

Morristown, NJ

Radiation Oncology Centers of Nevada (Tonopah)

Las Vegas, NV

GenesisCare Las Vegas Radiation Oncology (Tenaya)

Las Vegas, NV

Comprehensive Cancer Centers of Nevada (Northwest)

Las Vegas, NV

Comprehensive Cancer Centers of Nevada - Summerlin

Las Vegas, NV

Comprehensive Cancer Centers of Nevada (Southwest)

Las Vegas, NV

Comprehensive Cancer Centers of Nevada (Central Valley)

Las Vegas, NV

Radiation Oncology Centers of Nevada Southeast

Paradise, NV

Saint Mary's Regional Medical Center

Reno, NV

Glens Falls Hospital

Glens Falls, NY

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center

New York, NY

Saint Elizabeth Boardman Hospital

Boardman, OH

Miami Valley Hospital South

Centerville, OH

Geaugra Hospital

Chardon, OH

Adena Regional Medical Center

Chillicothe, OH

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Oncology Hematology Care Inc. (Kenwood)

Cincinnati, OH

TriHealth Bethesda North Hospital

Cincinnati, OH

Case Western Reserve University

Cleveland, OH

MetroHealth Medical Center

Cleveland, OH

Cleveland Clinic Taussig Cancer Institute

Cleveland, OH

University Hospitals Seidman Cancer Center Seidman Cancer Center at UH Case Medical

Cleveland, OH

Mount Carmel Health Center West

Columbus, OH

OhioHealth Riverside Methodist Hospital

Columbus, OH

OhioHealth Grant Medical Center

Columbus, OH

The Mark H. Zangmeister Center

Columbus, OH

Doctors Hospital

Columbus, OH

Dayton Physicians, LLC

Dayton, OH

Miami Valley Hospital

Dayton, OH

OhioHealth Grady Memorial Hospital Cancer Center

Delaware, OH

Blanchard Valley Hospital

Findlay, OH

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Wayne Healthcare

Greenville, OH

Kettering Medical Center

Kettering, OH

Saint Rita's Medical Center

Lima, OH

Marietta Memorial Hospital

Marietta, OH

UH Seidman Cancer Center (Landerbrook)

Mayfield Heights, OH

Ireland Cancer Center (Lake University)

Mentor, OH

Premier Health Atrium Medical Center - Middletown

Middletown, OH

Licking Memorial Hospital

Newark, OH

Newark Radiation Oncology

Newark, OH

Southern Ohio Medical Center

Portsmouth, OH

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, OH

Dayton Physicians (Wilson Memorial Hospital)

Sidney, OH

Springfield Regional Medical Center

Springfield, OH

Saint Vincent Mercy Medical Center

Toledo, OH

Mercy Health - St. Anne Hospital

Toledo, OH

Toledo Clinic Cancer Centers - Toledo

Toledo, OH

Dayton Physicians - Upper Valley Medical Center

Troy, OH

Premier Health Upper Valley Medical Center

Troy, OH

Saint Ann's Hospital

Westerville, OH

Mount Carmel Health Center (East)

Whitehall, OH

Genesis HealthCare System

Zanesville, OH

Mercy Hospital Oklahoma City

Oklahoma City, OK

Clackamas Radiation Oncology Center

Clackamas, OR

Bay Area Hospital

Coos Bay, OR

Providence Newberg Medical Center

Newberg, OR

Providence Portland Medical Center

Portland, OR

Oregon Health and Science University (OHSU) Knight Cancer Institute

Portland, OR

Lehigh Valley Health Network Cancer Institute

Allentown, PA

Geisinger Medical Center - Danville

Danville, PA

Geisinger - Hazleton Cancer Center

Hazleton, PA

Geisinger Medical Oncology (Evangelical Community Hospital)

Lewisburg, PA

Geisinger Health System (Lewistown Hospital)

Lewistown, PA

West Penn Hospital (Allegheny Health Network)

Pittsburgh, PA

Tower Health - Pottstown Hospital

Pottstown, PA

Geisinger Medical Oncology (Pottsville)

Pottsville, PA

Tower Health Reading Hospital

West Reading, PA

Geisinger Wyoming Valley Medical Center

Wilkes-Barre, PA

Prisma Health Cancer Institute - Greer Greer

Greer, SC

Prisma Health Cancer Institute - Seneca Lila Doyle Drive

Seneca, SC

The University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center

Dallas, TX

University of Texas Southwestern Medical Center (Fort Worth) Monty and Tex Moncrief Medical Center

Fort Worth, TX

MD Anderson Cancer Center The University of Texas

Houston, TX

Huntsman Cancer Institute University of Utah

Salt Lake City, UT

UVA Cancer Center University of Virginia Health System

Charlottesville, VA

PeaceHealth Medical Group

Bellingham, WA

St. Michael - Harrison Medical Center

Bremerton, WA

Highline Medical Center (Main Campus)

Burien, WA

Swedish Medical Center (Edmonds Campus)

Edmonds, WA

Providence Everett Medical Center

Everett, WA

Saint John Medical Center

Longview, WA

Fred Hutchinson / University of Washington Cancer Consortium Seattle Cancer Care Alliance (SCCA)

Seattle, WA

Swedish Medical Center (Ballard Campus)

Seattle, WA

Seattle Cancer Care Alliance SCCA

Seattle, WA

Swedish - First Hill Campus

Seattle, WA

Swedish - Cherry Hill Campus Cherry Hill Campus

Seattle, WA

University of Washington School of Medicine

Seattle, WA

St. Michael Cancer Center Virginia Mason Franciscan Health

Silverdale, WA

Providence St. Mary Regional Cancer Center

Walla Walla, WA

North Star Lodge Cancer Center

Yakima, WA

Essentia Health - Ashland Clinic

Ashland, WI

Aurora Cancer Care (Burlington)

Burlington, WI

Marshfield Medical Center Cancer Center - Eau Claire

Eau Claire, WI

Aurora Health Center (Fond du Lac)

Fond Du Lac, WI

Aurora Cancer Care (Grafton)

Grafton, WI

Aurora BayCare Medical Center

Green Bay, WI

Aurora Cancer Care (Kenosha South)

Kenosha, WI

Gundersen Lutheran Medical Center

La Crosse, WI

Marshfield Medical Center - Medical Offices Building

Marshfield, WI

Aurora Cancer Care (Milwaukee)

Milwaukee, WI

Aurora St. Luke's Medical Center

Milwaukee, WI

Aurora Sinai Medical Center

Milwaukee, WI

Marshfield Clinic (Minocqua Center)

Minocqua, WI

Aurora Cancer Care (Racine)

Mount Pleasant, WI

D. N. Greenwald Center

Mukwonago, WI

Cancer Center of Western Wisconsin

New Richmond, WI

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, WI

Aurora Health - Vince Lombardi Cancer Clinic (Summit)

Oconomowoc, WI

Vince Lombardi Cancer Clinic (Oshkosh)

Oshkosh, WI

Marshfield Clinic (Rice Lake Center)

Rice Lake, WI

Vince Lombardi Cancer Clinic - Sheboygan

Sheboygan, WI

Marshfield Clinic Cancer Care (Saint Michael's Hospital)

Stevens Point, WI

Vince Lombardi Cancer Clinic (Two Rivers)

Two Rivers, WI

Aurora Cancer Care (Milwaukee West)

Wauwatosa, WI

Aurora West Allis Medical Center

West Allis, WI

Marshfield Medical Center (Weston)

Weston, WI

West Virginia University

Morgantown, WV

Welch Cancer Center

Sheridan, WY

Not Currently Accepting Patients

The following is a listing of trial locations that are not currently open and accepting patients.

Mayo Clinic Surgery Center

Phoenix, AZ

Mayo Clinic (Arizona)

Phoenix, AZ

National Jewish Health (Main Campus)

Denver, CO

Colorado Blood Cancer Institute Sarah Cannon at Presbyterian/St. Luke's Medical Center (HealthONE)

Denver, CO

Rocky Mountain Cancer Centers - Denver Midtown Denver - Midtown

Denver, CO

SCL Health Saint Joseph Hospital

Denver, CO

HealthOne Rose Medical Center

Denver, CO

Centura Mercy Hospital

Durango, CO

Centura Southwest Oncology

Durango, CO

SCL Health St. Mary's Medical Center

Grand Junction, CO

National Jewish Health - Western Hematology Oncology

Lakewood, CO

Rocky Mountain Cancer Centers - Sky Ridge Medical Center (Lone Tree) Lone Tree - Skyridge

Lone Tree, CO

SCL Health Lutheran Medical Center

Wheat Ridge, CO

Grady Memorial Hospital

Atlanta, GA

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, GA

Alegent Health Mercy Hospital

Council Bluffs, IA

McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

McFarland Clinic PC (Jefferson)

Jefferson, IA

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Kootenai Clinic

Sandpoint, ID

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Loyola Center for Cancer Care and Research

Orland Park, IL

Rush - Copley Healthcare Center

Yorkville, IL

Springmill Medical Center

Indianapolis, IN

Saint Luke's South Hospital

Overland Park, KS

Flaget Memorial Hospital

Bardstown, KY

Commonwealth Cancer Center (Corbin)

Corbin, KY

Saints Mary and Elizabeth Hospital

Louisville, KY

Jewish Hospital Medical Center South

Shepherdsville, KY

Hematology Oncology Clinic

Baton Rouge, LA

Mercy Medical Center

Springfield, MA

University of Michigan Comprehensive Cancer Center

Ann Arbor, MI

Henry Ford Macomb Hospital

Clinton Township, MI

Cambridge Medical Center

Cambridge, MN

New Ulm Medical Center

New Ulm, MN

Fairview Northland Medical Center

Princeton, MN

Fairview Lakes Medical Center

Wyoming, MN

Mercy Hospital Washington

Washington, MO

Community Hospital of Anaconda

Anaconda, MT

SCL Health St. Vincent Healthcare SCL Health

Billings, MT

Saint James Community Hospital and Cancer Treatment Center

Butte, MT

Providence St. Patrick Hospital

Missoula, MT

CHI Health St. Elizabeth St. Elizabeth Regional Medical Center

Lincoln, NE

CHI Health Midlands

Papillion, NE

Comprehensive Cancer Centers of Nevada (Henderson)

Henderson, NV

Las Vegas Cancer Center (Henderson)

Henderson, NV

Comprehensive Cancer Centers of Nevada (Horizon Ridge)

Henderson, NV

GenesisCare Radiation Oncology (Henderson)

Henderson, NV

University Medical Center of Southern Nevada

Las Vegas, NV

Cancer and Blood Specialists of Nevada (Shadow) University Medical Center

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (La Canada) Intermountain Healthcare

Las Vegas, NV

Cancer & Blood Specialists of Nevada (Tenaya)

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (Tenaya) Intermountain Healthcare

Las Vegas, NV

Summerlin Hospital Medical Center

Las Vegas, NV

Las Vegas Cancer Center (Medical Center)

Las Vegas, NV

HealthCare Partners Nevada Fort Apache Radiation Oncology Clinic Intermountain Healthcare

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (Centennial Hills)

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (San Martin)

Spring Valley, NV

Strecker Cancer Center (Belpre)

Belpre, OH

Columbus Oncology and Hematology Associates

Columbus, OH

Good Samaritan Hospital (Dayton)

Dayton, OH

TriHealth Cancer Institute (Anderson)

Forestville, OH

Fairfield Medical Center

Lancaster, OH

OhioHealth Marion General Hospital

Marion, OH

Knox Community Hospital

Mount Vernon, OH

TriHealth Cancer Institute (Westside)

White Oak, OH

Geisinger Medical Group

State College, PA

Prisma Health Boiling Springs

Boiling Springs, SC

Prisma Health Cancer Institute - Easley Easley

Easley, SC

Revere Health (American Fork Main Campus)

American Fork, UT

Intermountain Medical Center

Murray, UT

Utah Cancer Specialists Cancer Center

Salt Lake City, UT

Saint Elizabeth Hospital

Enumclaw, WA

Saint Francis Hospital

Federal Way, WA

Saint Clare Hospital - CHI Franciscan Health

Lakewood, WA

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, WA

MultiCare Good Samaritan Hospital

Puyallup, WA

Multicare Health System

Tacoma, WA

ProHealth Waukesha Memorial Hospital

Waukesha, WI

Cheyenne Regional Medical Center (West)

Cheyenne, WY

Billings Clinic (Cody)

Cody, WY

Alaska
Anchorage Oncology Centre

Anchorage, AK

  • Recruiting
Alaska Breast Care and Surgery LLC

Anchorage, AK

  • Recruiting
Alaska Women's Cancer Care

Anchorage, AK

  • Recruiting
Katmai Oncology Group

Anchorage, AK

  • Recruiting
Providence Alaska Medical Center

Anchorage, AK

  • Recruiting
Arizona
Mayo Clinic Surgery Center

Phoenix, AZ

  • Suspended
Mayo Clinic (Arizona)

Phoenix, AZ

  • Suspended
California
Alta Bates Summit Medical Center - Alta Bates Campus

Berkeley, CA

  • Recruiting
Providence Saint Joseph Medical Center

Burbank, CA

  • Recruiting
Moores Cancer Center UC San Diego Health

La Jolla, CA

  • Recruiting
Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

  • Recruiting
Colorado
Rocky Mountain Cancer Centers (Aurora) Aurora

Aurora, CO

  • Recruiting
The Medical Center of Aurora (HealthONE)

Aurora, CO

  • Recruiting
Boulder Community Hospital

Boulder, CO

  • Recruiting
Rocky Mountain Cancer Center Boulder

Boulder, CO

  • Recruiting
Littleton Adventist Hospital

Centennial, CO

  • Recruiting
Centura Penrose Hospital

Colorado Springs, CO

  • Recruiting
Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

  • Recruiting
National Jewish Health (Main Campus)

Denver, CO

  • Suspended
Porter Adventist Hospital

Denver, CO

  • Recruiting
Colorado Blood Cancer Institute Sarah Cannon at Presbyterian/St. Luke's Medical Center (HealthONE)

Denver, CO

  • Suspended
HealthOne Presbyterian / St. Luke's Medical Center

Denver, CO

  • Recruiting
Rocky Mountain Cancer Centers - Denver Midtown Denver - Midtown

Denver, CO

  • Suspended
SCL Health Saint Joseph Hospital

Denver, CO

  • Suspended
HealthOne Rose Medical Center

Denver, CO

  • Suspended
Centura Mercy Hospital

Durango, CO

  • Suspended
Centura Southwest Oncology

Durango, CO

  • Suspended
HealthOne Swedish Medical Center

Englewood, CO

  • Recruiting
SCL Health St. Mary's Medical Center

Grand Junction, CO

  • Suspended
North Colorado Medical Center

Greeley, CO

  • Recruiting
National Jewish Health - Western Hematology Oncology

Lakewood, CO

  • Suspended
Centura St. Anthony Hospital

Lakewood, CO

  • Recruiting
Mountain Blue Cancer Care Center

Lakewood, CO

  • Recruiting
Rocky Mountain Cancer Center Littleton

Littleton, CO

  • Recruiting
Rocky Mountain Cancer Centers - Sky Ridge Medical Center (Lone Tree) Lone Tree - Skyridge

Lone Tree, CO

  • Suspended
HealthOne Sky Ridge Medical Center

Lone Tree, CO

  • Recruiting
Centura Longmont United Hospital

Longmont, CO

  • Recruiting
Rocky Mountain Cancer Centers (Longmont) Longmont

Longmont, CO

  • Recruiting
McKee Medical Center

Loveland, CO

  • Recruiting
Centura Parker Adventist Hospital

Parker, CO

  • Recruiting
Saint Mary Corwin Medical Center

Pueblo, CO

  • Recruiting
Rocky Mountain Cancer Center - Thornton

Thornton, CO

  • Recruiting
SCL Health Lutheran Medical Center

Wheat Ridge, CO

  • Suspended
Connecticut
Yale Cancer Center - Smilow Cancer Hospital Care Center Fairfield

Fairfield, CT

  • Recruiting
Smilow Cancer Hospital - Shoreline Medical Center Yale New Haven Health

Guilford, CT

  • Recruiting
Smilow Cancer Hospital at Saint Francis Hospital Trinity Health of New England

Hartford, CT

  • Recruiting
Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven

New Haven, CT

  • Recruiting
Yale-New Haven Hospital - North Haven Medical Center

North Haven, CT

  • Recruiting
Smilow Cancer Hospital Care Center (Orange)

Orange, CT

  • Recruiting
Smilow Cancer Hospital Care Center (Trumbull)

Trumbull, CT

  • Recruiting
Smilow Cancer Hospital - The Harold Leever Regional Cancer Center (Waterbury)

Waterbury, CT

  • Recruiting
Florida
Holy Cross Hospital Holy Cross Health, A Member of Trinity Health

Fort Lauderdale, FL

  • Recruiting
Cleveland Clinic Florida

Weston, FL

  • Recruiting
Georgia
Verified Winship Cancer Institute of Emory University
Winship Cancer Institute of Emory University

Atlanta, GA

  • Recruiting

SparkCures Verified Accurate, up-to-date information. Learn more

Grady Memorial Hospital

Atlanta, GA

  • Suspended
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, GA

  • Suspended
St. Joseph's/Candler Health System

Savannah, GA

  • Recruiting
Idaho
St. Luke's Cancer Institute - Boise

Boise, ID

  • Recruiting
Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

  • Recruiting
Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

  • Recruiting
Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

  • Recruiting
St. Luke's Cancer Institute (Meridian)

Meridian, ID

  • Recruiting
Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

  • Recruiting
Kootenai Cancer Center

Post Falls, ID

  • Recruiting
Kootenai Clinic

Sandpoint, ID

  • Suspended
Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

  • Recruiting
Illinois
Rush - Copley Medical Center

Aurora, IL

  • Recruiting
Loyola Center for Health at Burr Ridge

Burr Ridge, IL

  • Suspended
Carle Foundation Hospital (Vermilion)

Danville, IL

  • Recruiting
Carle (Effingham)

Effingham, IL

  • Recruiting
NorthShore University Health System - Evanston Hospital

Evanston, IL

  • Recruiting
Northwestern Medicine Cancer Center Delnor

Geneva, IL

  • Recruiting
UChicago Medicine Ingalls Memorial

Harvey, IL

  • Recruiting
Carle Foundation Hospital (Mattoon)

Mattoon, IL

  • Recruiting
Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

  • Recruiting
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

  • Suspended
Good Samaritan Regional Health Center

Mount Vernon, IL

  • Recruiting
Illinois Cancer Specialists

Niles, IL

  • Recruiting
Loyola Center for Cancer Care and Research

Orland Park, IL

  • Suspended
Carle Cancer Institute

Urbana, IL

  • Recruiting
Northwestern Medicine Cancer Center Warrenville

Warrenville, IL

  • Recruiting
Rush - Copley Healthcare Center

Yorkville, IL

  • Suspended
Indiana
Indiana University Health Hematology & Oncology (North Hospital) IU Health North Hospital Medical Office Building

Carmel, IN

  • Recruiting
Springmill Medical Center

Indianapolis, IN

  • Suspended
Iowa
Mary Greeley Medical Center

Ames, IA

  • Recruiting
McFarland Clinic PC

Ames, IA

  • Recruiting
McFarland Clinic PC (Boone)

Boone, IA

  • Recruiting
MercyOne Clive Cancer Center

Clive, IA

  • Recruiting
Mission Cancer & Blood (Clive) In Clive Cancer Center

Clive, IA

  • Recruiting
Alegent Health Mercy Hospital

Council Bluffs, IA

  • Suspended
Greater Regional Medical Center

Creston, IA

  • Recruiting
Medical Oncology and Hematology Associates (Des Moines) in UnityPoint Health - John Stoddard Cancer Center

Des Moines, IA

  • Recruiting
Broadlawns Medical Center

Des Moines, IA

  • Recruiting
Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

  • Recruiting
MercyOne Des Moines Medical Center

Des Moines, IA

  • Recruiting
McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

  • Suspended
McFarland Clinic PC (Jefferson)

Jefferson, IA

  • Suspended
McFarland Clinic PC (Marshalltown)

Marshalltown, IA

  • Suspended
MercyOne West Des Moines Medical Center

West Des Moines, IA

  • Recruiting
UnityPoint Health - Methodist West Hospital

West Des Moines, IA

  • Recruiting
Kansas
Saint Luke's South Hospital

Overland Park, KS

  • Suspended
Cotton O’Neil Cancer Center Stormont Vail Health

Topeka, KS

  • Recruiting
Kentucky
Flaget Memorial Hospital

Bardstown, KY

  • Suspended
Commonwealth Cancer Center (Corbin)

Corbin, KY

  • Suspended
Saint Joseph Hospital East

Lexington, KY

  • Recruiting
U of L Health - Jewish Hospital

Louisville, KY

  • Recruiting
Jewish Hospital Medical Center Northeast

Louisville, KY

  • Recruiting
U of L Health - Brown Cancer Center University of Louisville

Louisville, KY

  • Recruiting
Saints Mary and Elizabeth Hospital

Louisville, KY

  • Suspended
Jewish Hospital Medical Center South

Shepherdsville, KY

  • Suspended
Louisiana
Hematology Oncology Clinic

Baton Rouge, LA

  • Suspended
LSU Health Baton Rouge (North Clinic)

Baton Rouge, LA

  • Recruiting
Ochsner Medical Center

Jefferson, LA

  • Recruiting
Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

  • Recruiting
Maryland
Ascension Saint Agnes Hospital Saint Agnes Healthcare

Baltimore, MD

  • Recruiting
Massachusetts
Tufts Medical Center Cancer Center

Boston, MA

  • Recruiting
Mercy Medical Center

Springfield, MA

  • Suspended
Michigan
ProMedica Hickman Cancer Center Grace Christman Medical Building

Adrian, MI

  • Recruiting
University of Michigan Comprehensive Cancer Center

Ann Arbor, MI

  • Suspended
Bronson Battle Creek Cancer Care Center

Battle Creek, MI

  • Recruiting
St. Joseph Mercy Brighton Health Center

Brighton, MI

  • Recruiting
St. Joseph Mercy Canton Health Center

Canton, MI

  • Recruiting
Caro Cancer Center

Caro, MI

  • Recruiting
St. Joseph Mercy Chelsea Hospital

Chelsea, MI

  • Recruiting
Henry Ford Macomb Hospital

Clinton Township, MI

  • Suspended
Henry Ford Medical Center (Fairlane)

Dearborn, MI

  • Recruiting
Henry Ford Hospital

Detroit, MI

  • Recruiting
Genesys Hurley Cancer Institute

Flint, MI

  • Recruiting
Hurley Medical Center

Flint, MI

  • Recruiting
Helen DeVos Children's Hospital

Grand Rapids, MI

  • Recruiting
Mercy Health Saint Mary's

Grand Rapids, MI

  • Recruiting
Spectrum Health

Grand Rapids, MI

  • Recruiting
Allegiance Health

Jackson, MI

  • Recruiting
Bronson Methodist Hospital

Kalamazoo, MI

  • Recruiting
West Michigan Cancer Center

Kalamazoo, MI

  • Recruiting
Borgess Medical Center

Kalamazoo, MI

  • Recruiting
Sparrow Hospital

Lansing, MI

  • Recruiting
St. Mary Mercy Hospital St. Joe's Health

Livonia, MI

  • Recruiting
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, MI

  • Recruiting
Mercy Health Mercy Campus

Muskegon, MI

  • Recruiting
Lakeland Community Hospital

Niles, MI

  • Recruiting
Henry Ford Medical Center (Columbus)

Novi, MI

  • Recruiting
St. Joseph Mercy (Oakland)

Pontiac, MI

  • Recruiting
Spectrum Health Reed City Hospital

Reed City, MI

  • Recruiting
Saint Mary's of Michigan

Saginaw, MI

  • Recruiting
Oncology Hematology Associates of Saginaw Valley PC

Saginaw Valley, MI

  • Recruiting
Spectrum Health Lakeland Medical Center

St. Joseph, MI

  • Recruiting
Spectrum Health Marie Yeager Cancer Center

St. Joseph, MI

  • Recruiting
Ascension Saint Joseph Hospital

Tawas City, MI

  • Recruiting
Munson Medical Center

Traverse City, MI

  • Recruiting
Ascension Macomb-Oakland Hospital - Webber Cancer Center

Warren, MI

  • Recruiting
Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

  • Recruiting
St. Joseph Mercy Ann Arbor Hospital

Ypsilanti, MI

  • Recruiting
Minnesota
Essentia Health Saint Joseph's Medical Center

Brainerd, MN

  • Recruiting
M Health Fairview Ridges Hospital

Burnsville, MN

  • Recruiting
Cambridge Medical Center

Cambridge, MN

  • Suspended
Mercy Hospital

Coon Rapids, MN

  • Recruiting
Essentia Health

Deer River, MN

  • Recruiting
Essentia Health Saint Mary's Medical Center

Duluth, MN

  • Recruiting
Essentia Health (Miller-Dwan Building)

Duluth, MN

  • Recruiting
Fairview Southdale Hospital

Edina, MN

  • Recruiting
Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

  • Recruiting
Unity Hospital

Fridley, MN

  • Recruiting
Essentia Health Hibbing Clinic

Hibbing, MN

  • Recruiting
Fairview Maple Grove Medical Center

Maple Grove, MN