Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma DETER-SMM

What's the purpose of this trial?

This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  • Patients must be diagnosed with asymptomatic high-risk smoldering multiple myeloma (SMM) within the past 12 months. High-risk is defined by any one of the following factors:
    • Abnormal serum free light chain ratio (≤ 0.125 or ≥ 8.0 and involved chain < 100 mg/L) by serum free light chain (FLC) assay
    • Serum M-protein level ≥ 3 gm/dL
    • Presence of t(4;14) or del 17p or 1q gain by conventional cytogenetics or fluorescence in situ hybridization (FISH) studies.
  • Bone marrow aspirate and/or biopsy is required to be performed within 28 days prior to randomization and must demonstrate 10-59% clonal plasma cells.
  • ≥ 1 g/dL on serum protein electrophoresis (within 28 days prior to randomization).
  • ≥ 200 mg of monoclonal protein on a 24 hour urine protein electrophoresis (within 28 days prior to randomization).
    • NOTE: In the rare situation where the serum protein electrophoresis (SPEP) is felt to be unreliable, then quantitative immunoglobulin levels on nephelometry or turbidometry can be accepted.
  • SPEP, urine protein electrophoresis (UPEP), and serum FLC are required to be performed within 28 days prior to randomization.
    • NOTE: UPEP (on a 24-hour collection) is required; no substitute method is acceptable. Urine must be followed monthly if the baseline urine M-spike is >= 200 mg/24 hour (hr), and urine in addition to serum must be followed in order to confirm a very good partial response (VGPR) or higher response.
  • Patients must have no lytic lesions, no known plasmacytoma, and no unexplained hypercalcemia (i.e., > 11 mg/dL or 1mg/dL above upper limit of normal [ULN]).
  • Hemoglobin >= 11 g/dL (within 28 days prior to randomization).
  • Platelet count >= 100,000 cells/mm^3 (within 28 days prior to randomization).
  • Absolute neutrophil count >= 1500 cells/mm^3 (within 28 days prior to randomization).
  • Calculated creatinine clearance >= 30 mL/min (within 28 days prior to randomization).
  • Bilirubin =< 1.5 mg/dL (within 28 days prior to randomization).
  • Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 times the upper limit of normal (within 28 days prior to randomization).
  • Patients must not have any prior or concurrent systemic or radiation therapy for the treatment of myeloma. Patients must also not have contraindication to deep vein thrombosis (DVT) prophylaxis/aspirin.
  • Patients must not have more than one focal marrow lesion on magnetic resonance imaging (MRI) of either pelvis or spine.
  • Concurrent use of erythropoietin is not allowed while on study therapy.
  • Prior or glucocorticosteroid therapy for the treatment of multiple myeloma is not permitted. Prior systemic glucocorticosteroid use for the treatment of non-malignant disorders is permitted; concurrent use after registration on the study should be restricted to the equivalent of prednisone 10 mg per day. Prior or concurrent topical or localized glucocorticosteroid therapy to treat non-malignant comorbid disorders is permitted.
  • Patients must not have active, uncontrolled seizure disorder. Patients must not have had a seizure in the last 6 months.
  • Patients must not have uncontrolled intercurrent illness including uncontrolled hypertension, symptomatic congestive heart failure, unstable angina, uncontrolled cardiac arrhythmia, uncontrolled psychiatric illness or social situation that would limit compliance with the study, or a prior history of Stevens Johnson syndrome.
  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2.
  • Patients with monoclonal gammopathy of undetermined significance are not eligible.
  • Patients must not have grade 2 or higher peripheral neuropathy per CTCAE.
  • Patients must not have active, uncontrolled infection.
  • Patients may have a history of current or previous deep vein thrombosis or pulmonary embolism but are required to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation.
  • Patients should not have New York Heart Association classification III or IV heart failure at baseline.
  • Patients with a history of prior malignancy are eligible provided they were treated with curative intent and have been free of disease for the time period considered appropriate for cure of the specific cancer. For most diseases this time frame is 5 years.
  • Patients must agree to register into the mandatory Risk Evaluation and Mitigation Strategy (REMS) program and be willing and able to comply with the requirements of REMS.
  • Women must not be pregnant due to potential harm to the fetus from daratumumab and lenalidomide. All females of childbearing potential (FCBP) must have a blood test or urine study with a sensitivity of at least 25 mIU/mL within 10-14 days prior to the first dose of lenalidomide and again within 24 hours prior to the first dose of lenalidomide. FCBP must also agree to ongoing pregnancy testing while on treatment. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
  • Females of childbearing potential (FCBP) must either abstain from sexual intercourse for the duration of their participation in the study or agree to use TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME for 1) at least 28 days before starting study treatment; 2) while participating in the study; 3) during dose interruptions; and 4) for at least 28 days after the last dose of protocol treatment (FCBP who are assigned to Arm A and receive daratumumab must extend this contraception requirement to 3 months after the last dose of protocol treatment). Women must also agree to not breastfeed during this same time period. Men must agree to either abstain from sexual intercourse for the duration of their participation in the study or use a latex condom during sexual contact with a FCBP while participating in the study and for 28 days after the last dose of protocol treatment even if they have had a successful vasectomy. Men must also agree to abstain from donating sperm while on study treatment and for 28 days after the last dose of protocol treatment even if they have had a successful vasectomy. Both women and men must both agree to abstain from donating blood during study participation and for at least 28 days after the last dose of protocol treatment.
  • Human immunodeficiency virus (HIV)+ patients with undetectable HIV viral loads tested within 6 months are eligible.
  • Patients should not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to daratumumab, lenalidomide, or dexamethasone.

Additional Trial Information

Phase 3

Enrollment: 288 patients (estimated)

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Need Help?

Interested in joining or learning more about this trial?

(888) 828-2206

Trial Links

Read the latest news and updates on this trial.

Daratumumab, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma: Outcomes From the MAIA Trial

February 05, 2019

In patients with newly diagnosed multiple myeloma who are not eligible for stem cell transplantation, the addition of daratumumab to lenalidomide and dexamethasone significantly reduced the risk of death or disease progression by 44%, according to a late-breaking abstract presentation by Thierry Facon, MD, of the Hospital Claude Huriez in Lille, France, at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition.

Read more

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alaska

Anchorage Oncology Centre

Anchorage, AK

Open and Accepting

Alaska Breast Care and Surgery LLC

Anchorage, AK

Open and Accepting

Alaska Women's Cancer Care

Anchorage, AK

Open and Accepting

Katmai Oncology Group

Anchorage, AK

Open and Accepting

Providence Alaska Medical Center

Anchorage, AK

Open and Accepting

Arizona

Mayo Clinic Surgery Center

Phoenix, AZ

Temporarily Suspended

Mayo Clinic (Arizona)

Phoenix, AZ

Temporarily Suspended

California

Alta Bates Summit Medical Center - Alta Bates Campus

Berkeley, CA

Open and Accepting

Providence Saint Joseph Medical Center

Burbank, CA

Open and Accepting

Moores Cancer Center University of California UC San Diego Health

La Jolla, CA

Open and Accepting

Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

Open and Accepting

Colorado

Rocky Mountain Cancer Centers (Aurora) Aurora

Aurora, CO

Open and Accepting

The Medical Center of Aurora (HealthONE)

Aurora, CO

Open and Accepting

Boulder Community Hospital

Boulder, CO

Open and Accepting

Rocky Mountain Cancer Center Boulder

Boulder, CO

Open and Accepting

Littleton Adventist Hospital

Centennial, CO

Open and Accepting

Centura Penrose Hospital

Colorado Springs, CO

Open and Accepting

Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

Open and Accepting

National Jewish Health (Main Campus)

Denver, CO

Temporarily Suspended

Porter Adventist Hospital

Denver, CO

Open and Accepting

Colorado Blood Cancer Institute Sarah Cannon at Presbyterian/St. Luke's Medical Center (HealthONE)

Denver, CO

Temporarily Suspended

Sarah Cannon Research Institute at HealthONE Presbyterian/St. Luke's Medical Center

Denver, CO

Open and Accepting

Rocky Mountain Cancer Centers - Denver Midtown Denver - Midtown

Denver, CO

Temporarily Suspended

SCL Health Saint Joseph Hospital

Denver, CO

Temporarily Suspended

HealthOne Rose Medical Center

Denver, CO

Temporarily Suspended

Centura Mercy Hospital

Durango, CO

Temporarily Suspended

Centura Southwest Oncology

Durango, CO

Temporarily Suspended

HealthOne Swedish Medical Center

Englewood, CO

Open and Accepting

SCL Health St. Mary's Medical Center

Grand Junction, CO

Temporarily Suspended

North Colorado Medical Center

Greeley, CO

Open and Accepting

National Jewish Health - Western Hematology Oncology

Lakewood, CO

Temporarily Suspended

Centura St. Anthony Hospital

Lakewood, CO

Open and Accepting

Mountain Blue Cancer Care Center

Lakewood, CO

Open and Accepting

Rocky Mountain Cancer Center Littleton

Littleton, CO

Open and Accepting

Rocky Mountain Cancer Centers - Sky Ridge Medical Center (Lone Tree) Lone Tree - Skyridge

Lone Tree, CO

Temporarily Suspended

HealthOne Sky Ridge Medical Center

Lone Tree, CO

Open and Accepting

Centura Longmont United Hospital

Longmont, CO

Open and Accepting

Rocky Mountain Cancer Centers (Longmont) Longmont

Longmont, CO

Open and Accepting

McKee Medical Center

Loveland, CO

Open and Accepting

Centura Parker Adventist Hospital

Parker, CO

Open and Accepting

Saint Mary Corwin Medical Center

Pueblo, CO

Open and Accepting

Rocky Mountain Cancer Center - Thornton

Thornton, CO

Open and Accepting

SCL Health Lutheran Medical Center

Wheat Ridge, CO

Temporarily Suspended

Connecticut

Yale Cancer Center - Smilow Cancer Hospital Care Center Fairfield

Fairfield, CT

Open and Accepting

Smilow Cancer Hospital - Shoreline Medical Center Yale New Haven Health

Guilford, CT

Open and Accepting

Smilow Cancer Hospital at Saint Francis Hospital Trinity Health of New England

Hartford, CT

Open and Accepting

Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven

New Haven, CT

Open and Accepting

Yale-New Haven Hospital - North Haven Medical Center

North Haven, CT

Open and Accepting

Smilow Cancer Hospital Care Center (Orange)

Orange, CT

Open and Accepting

Smilow Cancer Hospital Care Center (Trumbull)

Trumbull, CT

Open and Accepting

Smilow Cancer Hospital - The Harold Leever Regional Cancer Center (Waterbury)

Waterbury, CT

Open and Accepting

Florida

Michigan Cancer Research Consortium - Holy Cross Hospital Holy Cross Health, A Member of Trinity Health

Fort Lauderdale, FL

Open and Accepting

Cleveland Clinic Florida

Weston, FL

Open and Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Open and Accepting

Grady Memorial Hospital

Atlanta, GA

Temporarily Suspended

Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler Health System, Inc.

Savannah, GA

Temporarily Suspended

St. Joseph's/Candler Health System

Savannah, GA

Open and Accepting

Idaho

St. Luke's Cancer Institute - Boise

Boise, ID

Open and Accepting

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Open and Accepting

Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

Open and Accepting

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

Open and Accepting

St. Luke's Cancer Institute (Meridian)

Meridian, ID

Open and Accepting

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Open and Accepting

Kootenai Cancer Center

Post Falls, ID

Open and Accepting

Kootenai Clinic

Sandpoint, ID

Temporarily Suspended

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Open and Accepting

Illinois

Rush - Copley Medical Center

Aurora, IL

Open and Accepting

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Temporarily Suspended

Carle Foundation Hospital (Vermilion)

Danville, IL

Open and Accepting

Carle (Effingham)

Effingham, IL

Open and Accepting

NorthShore University Health System - Evanston Hospital

Evanston, IL

Open and Accepting

Northwestern Medicine Cancer Center Delnor

Geneva, IL

Open and Accepting

UChicago Medicine Ingalls Memorial

Harvey, IL

Open and Accepting

Carle Foundation Hospital (Mattoon)

Mattoon, IL

Open and Accepting

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Open and Accepting

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Temporarily Suspended

Good Samaritan Regional Health Center

Mount Vernon, IL

Open and Accepting

Illinois Cancer Specialists

Niles, IL

Open and Accepting

Loyola Center for Cancer Care and Research

Orland Park, IL

Temporarily Suspended

Carle Cancer Institute

Urbana, IL

Open and Accepting

Northwestern Medicine Cancer Center Warrenville

Warrenville, IL

Open and Accepting

Rush - Copley Healthcare Center

Yorkville, IL

Temporarily Suspended

Indiana

Indiana University Health Hematology & Oncology (North Hospital) IU Health North Hospital Medical Office Building

Carmel, IN

Open and Accepting

Springmill Medical Center

Indianapolis, IN

Temporarily Suspended

Iowa

Mary Greeley Medical Center

Ames, IA

Open and Accepting

McFarland Clinic PC

Ames, IA

Open and Accepting

McFarland Clinic PC (Boone)

Boone, IA

Open and Accepting

MercyOne Clive Cancer Center

Clive, IA

Open and Accepting

Mission Cancer & Blood (Clive) In Clive Cancer Center

Clive, IA

Open and Accepting

Alegent Health Mercy Hospital

Council Bluffs, IA

Temporarily Suspended

Greater Regional Medical Center

Creston, IA

Open and Accepting

Medical Oncology and Hematology Associates (Des Moines) in UnityPoint Health - John Stoddard Cancer Center

Des Moines, IA

Open and Accepting

Broadlawns Medical Center

Des Moines, IA

Open and Accepting

Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

Open and Accepting

MercyOne Des Moines Medical Center

Des Moines, IA

Open and Accepting

McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

Temporarily Suspended

McFarland Clinic PC (Jefferson)

Jefferson, IA

Temporarily Suspended

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Temporarily Suspended

MercyOne West Des Moines Medical Center

West Des Moines, IA

Open and Accepting

UnityPoint Health - Methodist West Hospital

West Des Moines, IA

Open and Accepting

Kansas

Saint Luke's South Hospital

Overland Park, KS

Temporarily Suspended

Cotton O’Neil Cancer Center Stormont Vail Health

Topeka, KS

Open and Accepting

Kentucky

Flaget Memorial Hospital

Bardstown, KY

Temporarily Suspended

Commonwealth Cancer Center (Corbin)

Corbin, KY

Temporarily Suspended

Saint Joseph Hospital East

Lexington, KY

Open and Accepting

U of L Health - Jewish Hospital

Louisville, KY

Open and Accepting

Jewish Hospital Medical Center Northeast

Louisville, KY

Open and Accepting

U of L Health - Brown Cancer Center University of Louisville

Louisville, KY

Open and Accepting

Saints Mary and Elizabeth Hospital

Louisville, KY

Temporarily Suspended

Jewish Hospital Medical Center South

Shepherdsville, KY

Temporarily Suspended

Louisiana

Hematology Oncology Clinic

Baton Rouge, LA

Temporarily Suspended

LSU Health Baton Rouge (North Clinic)

Baton Rouge, LA

Open and Accepting

Ochsner Medical Center

Jefferson, LA

Open and Accepting

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Open and Accepting

Maryland

Ascension Saint Agnes Hospital Saint Agnes Healthcare

Baltimore, MD

Open and Accepting

Massachusetts

Tufts Medical Center Cancer Center

Boston, MA

Open and Accepting

Mercy Medical Center

Springfield, MA

Temporarily Suspended

Michigan

ProMedica Hickman Cancer Center Grace Christman Medical Building

Adrian, MI

Open and Accepting

University of Michigan Comprehensive Cancer Center Rogel Cancer Center

Ann Arbor, MI

Temporarily Suspended

Bronson Battle Creek Cancer Care Center

Battle Creek, MI

Open and Accepting

St. Joseph Mercy Brighton Health Center

Brighton, MI

Open and Accepting

St. Joseph Mercy Canton Health Center

Canton, MI

Open and Accepting

Caro Cancer Center

Caro, MI

Open and Accepting

Chelsea Hospital Michigan Cancer Research Consortium

Chelsea, MI

Open and Accepting

Henry Ford Macomb Hospital

Clinton Township, MI

Temporarily Suspended

Henry Ford Medical Center (Fairlane)

Dearborn, MI

Open and Accepting

Henry Ford Hospital

Detroit, MI

Open and Accepting

Michigan Cancer Research Consortium - Genesys Hurley Cancer Institute

Flint, MI

Open and Accepting

Hurley Medical Center

Flint, MI

Open and Accepting

Helen DeVos Children's Hospital

Grand Rapids, MI

Open and Accepting

Mercy Health Saint Mary's

Grand Rapids, MI

Open and Accepting

Spectrum Health

Grand Rapids, MI

Open and Accepting

Allegiance Health

Jackson, MI

Open and Accepting

Bronson Methodist Hospital

Kalamazoo, MI

Open and Accepting

West Michigan Cancer Center

Kalamazoo, MI

Open and Accepting

Cancer Research Consortium of West Michigan - Ascension Borgess Cancer Medical Center

Kalamazoo, MI

Open and Accepting

Sparrow Hospital

Lansing, MI

Open and Accepting

St. Mary Mercy Hospital St. Joe's Health

Livonia, MI

Open and Accepting

Michigan Cancer Research Consortium - Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, MI

Open and Accepting

Trinity Health Muskegon Hospital

Muskegon, MI

Open and Accepting

Lakeland Community Hospital

Niles, MI

Open and Accepting

Henry Ford Medical Center (Columbus)

Novi, MI

Open and Accepting

St. Joseph Mercy (Oakland)

Pontiac, MI

Open and Accepting

Spectrum Health Reed City Hospital

Reed City, MI

Open and Accepting

Saint Mary's of Michigan

Saginaw, MI

Open and Accepting

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, MI

Open and Accepting

Spectrum Health Lakeland Medical Center

St. Joseph, MI

Open and Accepting

Spectrum Health Marie Yeager Cancer Center

St. Joseph, MI

Open and Accepting

Ascension Saint Joseph Hospital

Tawas City, MI

Open and Accepting

Munson Medical Center

Traverse City, MI

Open and Accepting

Ascension Macomb-Oakland Hospital - Webber Cancer Center

Warren, MI

Open and Accepting

Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

Open and Accepting

St. Joseph Mercy Ann Arbor Hospital

Ypsilanti, MI

Open and Accepting

Minnesota

Essentia Health Saint Joseph's Medical Center

Brainerd, MN

Open and Accepting

M Health Fairview Ridges Hospital

Burnsville, MN

Open and Accepting

Cambridge Medical Center

Cambridge, MN

Temporarily Suspended

Mercy Hospital

Coon Rapids, MN

Open and Accepting

Essentia Health

Deer River, MN

Open and Accepting

Essentia Health Saint Mary's Medical Center

Duluth, MN

Open and Accepting

Essentia Health (Miller-Dwan Building)

Duluth, MN

Open and Accepting

Fairview Southdale Hospital

Edina, MN

Open and Accepting

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Open and Accepting

Unity Hospital

Fridley, MN

Open and Accepting

Essentia Health Hibbing Clinic

Hibbing, MN

Open and Accepting

Fairview Maple Grove Medical Center

Maple Grove, MN

Open and Accepting

Minnesota Oncology Maplewood Cancer Center

Maplewood, MN

Open and Accepting

M Health Fairview St. John's Hospital

Maplewood, MN

Open and Accepting

Abbott-Northwestern Hospital Allina Health

Minneapolis, MN

Open and Accepting

Hennepin County Medical Center

Minneapolis, MN

Open and Accepting

Health Partners Inc.

Minneapolis, MN

Open and Accepting

Monticello Cancer Center

Monticello, MN

Open and Accepting

New Ulm Medical Center

New Ulm, MN

Temporarily Suspended

Fairview Northland Medical Center

Princeton, MN

Temporarily Suspended

North Memorial Medical Health Center

Robbinsdale, MN

Open and Accepting

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

Saint Francis Regional Medical Center

Shakopee, MN

Open and Accepting

Park Nicollet Specialty Center at Methodist Hospital

St. Louis Park, MN

Open and Accepting

Regions Hospital

St. Paul, MN

Open and Accepting

United Hospital

St. Paul, MN

Open and Accepting

Lakeview Hospital

Stillwater, MN

Open and Accepting

Essentia Health Virginia Clinic

Virginia, MN

Open and Accepting

Ridgeview Medical Center

Waconia, MN

Open and Accepting

Rice Memorial Hospital

Willmar, MN

Open and Accepting

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Open and Accepting

Fairview Lakes Medical Center

Wyoming, MN

Temporarily Suspended

Missouri

Alvin J. Siteman Cancer Center Washington University Medical Campus

St. Louis, MO

Open and Accepting

Saint Louis Cancer and Breast Institute

Ballwin, MO

Open and Accepting

Central Care Cancer Center

Bolivar, MO

Open and Accepting

Siteman Cancer Center at Barnes-Jewish West County Hospital

Creve Coeur, MO

Open and Accepting

Freeman Cornell-Beshore Cancer Institute

Joplin, MO

Open and Accepting

Saint Luke's Hospital of Kansas City

Kansas City, MO

Open and Accepting

Saint Luke's East (Lee's Summit)

Lees Summit, MO

Open and Accepting

Mercy Clinic Cancer and Hematology (Rolla)

Rolla, MO

Open and Accepting

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Open and Accepting

Mercy Hospital Springfield

Springfield, MO

Open and Accepting

CoxHealth South Hospital Cox Medical Center South

Springfield, MO

Open and Accepting

Heartland Regional Medical Center

St. Joseph, MO

Open and Accepting

Siteman Cancer Center (South St. Louis County)

St. Louis, MO

Open and Accepting

Mercy Hospital South

St. Louis, MO

Open and Accepting

Mercy Hospital Washington

Washington, MO

Temporarily Suspended

Montana

Community Hospital of Anaconda

Anaconda, MT

Temporarily Suspended

Billings Clinic Cancer Center

Billings, MT

Open and Accepting

SCL Health St. Vincent Healthcare SCL Health

Billings, MT

Temporarily Suspended

Bozeman Deaconess Hospital

Bozeman, MT

Open and Accepting

Saint James Community Hospital and Cancer Treatment Center

Butte, MT

Temporarily Suspended

Benefis Sletten Cancer Institute

Great Falls, MT

Open and Accepting

Great Falls Clinic Specialty Center

Great Falls, MT

Open and Accepting

Kalispell Regional Medical Center

Kalispell, MT

Open and Accepting

Providence St. Patrick Hospital

Missoula, MT

Temporarily Suspended

Community Medical Hospital

Missoula, MT

Open and Accepting

Nebraska

CHI Health St. Francis

Grand Island, NE

Open and Accepting

CHI Health Good Samaritan Hospital

Kearney, NE

Open and Accepting

CHI Health St. Elizabeth St. Elizabeth Regional Medical Center

Lincoln, NE

Temporarily Suspended

CHI Health Creighton University Medical Center

Omaha, NE

Open and Accepting

CHI Health Midlands

Papillion, NE

Temporarily Suspended

Nevada

Comprehensive Cancer Centers of Nevada (Henderson)

Henderson, NV

Temporarily Suspended

Las Vegas Cancer Center (Henderson)

Henderson, NV

Temporarily Suspended

Comprehensive Cancer Centers of Nevada (Horizon Ridge)

Henderson, NV

Temporarily Suspended

GenesisCare Radiation Oncology (Henderson)

Henderson, NV

Temporarily Suspended

University Medical Center of Southern Nevada

Las Vegas, NV

Temporarily Suspended

Cancer and Blood Specialists of Nevada (Shadow) University Medical Center

Las Vegas, NV

Temporarily Suspended

Radiation Oncology Centers of Nevada (Tonopah)

Las Vegas, NV

Open and Accepting

GenesisCare Las Vegas Radiation Oncology (Tenaya)

Las Vegas, NV

Open and Accepting

HealthCare Partners Medical Group Oncology/Hematology (La Canada) Intermountain Healthcare

Las Vegas, NV

Temporarily Suspended

Cancer & Blood Specialists of Nevada (Tenaya)

Las Vegas, NV

Temporarily Suspended

Comprehensive Cancer Centers of Nevada (Northwest)

Las Vegas, NV

Open and Accepting

HealthCare Partners Medical Group Oncology/Hematology (Tenaya) Intermountain Healthcare

Las Vegas, NV

Temporarily Suspended

Comprehensive Cancer Centers of Nevada - Summerlin

Las Vegas, NV

Open and Accepting

Summerlin Hospital Medical Center

Las Vegas, NV

Temporarily Suspended

Las Vegas Cancer Center (Medical Center)

Las Vegas, NV

Temporarily Suspended

HealthCare Partners Nevada Fort Apache Radiation Oncology Clinic Intermountain Healthcare

Las Vegas, NV

Temporarily Suspended

Comprehensive Cancer Centers of Nevada (Southwest)

Las Vegas, NV

Open and Accepting

Comprehensive Cancer Centers of Nevada (Central Valley)

Las Vegas, NV

Open and Accepting

HealthCare Partners Medical Group Oncology/Hematology (Centennial Hills)

Las Vegas, NV

Temporarily Suspended

Radiation Oncology Centers of Nevada Southeast

Paradise, NV

Open and Accepting

Saint Mary's Regional Medical Center

Reno, NV

Open and Accepting

HealthCare Partners Medical Group Oncology/Hematology (San Martin)

Spring Valley, NV

Temporarily Suspended

New Jersey

Morristown Medical Center Atlantic Health System

Morristown, NJ

Open and Accepting

New York

Glens Falls Hospital

Glens Falls, NY

Open and Accepting

Herbert Irving Comprehensive Cancer Center (Columbia University) Columbia University Medical Center

New York, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Open and Accepting

Atrium Health's Levine Cancer Institute - Charlotte (Main) Atrium Health

Charlotte, NC

Open and Accepting

North Dakota

Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

Open and Accepting

Ohio

Strecker Cancer Center (Belpre)

Belpre, OH

Temporarily Suspended

Saint Elizabeth Boardman Hospital

Boardman, OH

Open and Accepting

Miami Valley Hospital South

Centerville, OH

Open and Accepting

Geaugra Hospital

Chardon, OH

Open and Accepting

Adena Regional Medical Center

Chillicothe, OH

Open and Accepting

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Open and Accepting

Oncology Hematology Care Inc. (Kenwood)

Cincinnati, OH

Open and Accepting

TriHealth Bethesda North Hospital

Cincinnati, OH

Open and Accepting

Case Western Reserve University

Cleveland, OH

Open and Accepting

MetroHealth Medical Center

Cleveland, OH

Open and Accepting

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Open and Accepting

University Hospitals Seidman Cancer Center Seidman Cancer Center at UH Case Medical

Cleveland, OH

Open and Accepting

Mount Carmel Health Center West

Columbus, OH

Open and Accepting

Columbus Oncology and Hematology Associates

Columbus, OH

Temporarily Suspended

OhioHealth Riverside Methodist Hospital

Columbus, OH

Open and Accepting

OhioHealth Grant Medical Center

Columbus, OH

Open and Accepting

The Mark H. Zangmeister Center

Columbus, OH

Open and Accepting

Doctors Hospital

Columbus, OH

Open and Accepting

Dayton Physicians, LLC

Dayton, OH

Open and Accepting

Good Samaritan Hospital (Dayton)

Dayton, OH

Temporarily Suspended

Miami Valley Hospital

Dayton, OH

Open and Accepting

OhioHealth Grady Memorial Hospital Cancer Center

Delaware, OH

Open and Accepting

Blanchard Valley Hospital

Findlay, OH

Open and Accepting

TriHealth Cancer Institute (Anderson)

Forestville, OH

Temporarily Suspended

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Open and Accepting

Wayne Healthcare

Greenville, OH

Open and Accepting

Kettering Cancer Care

Kettering, OH

Open and Accepting

Fairfield Medical Center

Lancaster, OH

Temporarily Suspended

Saint Rita's Medical Center

Lima, OH

Open and Accepting

Marietta Memorial Hospital

Marietta, OH

Open and Accepting

OhioHealth Marion General Hospital

Marion, OH

Temporarily Suspended

UH Seidman Cancer Center (Landerbrook)

Mayfield Heights, OH

Open and Accepting

UH Seidman Cancer Center (Lake Health)

Mentor, OH

Open and Accepting

Premier Health Atrium Medical Center - Middletown

Middletown, OH

Open and Accepting

Knox Community Hospital

Mount Vernon, OH

Temporarily Suspended

Licking Memorial Hospital

Newark, OH

Open and Accepting

Newark Radiation Oncology

Newark, OH

Open and Accepting

Southern Ohio Medical Center

Portsmouth, OH

Open and Accepting

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, OH

Open and Accepting

Dayton Physicians (Wilson Memorial Hospital)

Sidney, OH

Open and Accepting

Springfield Regional Medical Center

Springfield, OH

Open and Accepting

Saint Vincent Mercy Medical Center

Toledo, OH

Open and Accepting

Mercy Health - St. Anne Hospital

Toledo, OH

Open and Accepting

Toledo Clinic Cancer Centers - Toledo

Toledo, OH

Open and Accepting

Dayton Physicians - Upper Valley Medical Center

Troy, OH

Open and Accepting

Premier Health Upper Valley Medical Center

Troy, OH

Open and Accepting

Saint Ann's Hospital

Westerville, OH

Open and Accepting

TriHealth Cancer Institute (Westside)

White Oak, OH

Temporarily Suspended