This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.
SparkCures ID | 999 |
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Trial Phase | Phase 3 |
Enrollment | 288 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Inclusion Criteria:
The following is a listing of trial locations that are open and accepting patients.
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Anchorage, AK
Anchorage, AK
Anchorage, AK
Anchorage, AK
Anchorage, AK
Berkeley, CA
Burbank, CA
La Jolla, CA
Aurora, CO
Boulder, CO
Boulder, CO
Centennial, CO
Colorado Springs, CO
Colorado Springs, CO
Denver, CO
Englewood, CO
Greeley, CO
Lakewood, CO
Lakewood, CO
Littleton, CO
Lone Tree, CO
Longmont, CO
Longmont, CO
Loveland, CO
Parker, CO
Pueblo, CO
Thornton, CO
North Haven, CT
Orange, CT
Trumbull, CT
Fort Lauderdale, FL
Weston, FL
Savannah, GA
Ames, IA
Ames, IA
Boone, IA
Clive, IA
Creston, IA
Des Moines, IA
Des Moines, IA
Des Moines, IA
West Des Moines, IA
West Des Moines, IA
Boise, ID
Boise City, ID
Coeur d'Alene, ID
Fruitland, ID
Meridian, ID
Post Falls, ID
Twin Falls, ID
Aurora, IL
Danville, IL
Effingham, IL
Geneva, IL
Harvey, IL
Mattoon, IL
Mount Vernon, IL
Niles, IL
Urbana, IL
Warrenville, IL
Lexington, KY
Louisville, KY
Louisville, KY
Louisville, KY
Baton Rouge, LA
Jefferson, LA
New Orleans, LA
Boston, MA
Baltimore, MD
Battle Creek, MI
Brighton, MI
Canton, MI
Caro, MI
Chelsea, MI
Dearborn, MI
Detroit, MI
Flint, MI
Flint, MI
Grand Rapids, MI
Grand Rapids, MI
Grand Rapids, MI
Jackson, MI
Kalamazoo, MI
Kalamazoo, MI
Kalamazoo, MI
Lansing, MI
Livonia, MI
Muskegon, MI
Niles, MI
Novi, MI
Pontiac, MI
Reed City, MI
Saginaw, MI
Saginaw Valley, MI
St. Joseph, MI
St. Joseph, MI
Tawas City, MI
Traverse City, MI
West Bloomfield, MI
Ypsilanti, MI
Brainerd, MN
Burnsville, MN
Coon Rapids, MN
Deer River, MN
Duluth, MN
Duluth, MN
Edina, MN
Fergus Falls, MN
Fridley, MN
Hibbing, MN
Maple Grove, MN
Maplewood, MN
Maplewood, MN
Minneapolis, MN
Minneapolis, MN
Minneapolis, MN
Monticello, MN
Robbinsdale, MN
Rochester, MN
Shakopee, MN
St. Louis Park, MN
St. Paul, MN
St. Paul, MN
Stillwater, MN
Virginia, MN
Waconia, MN
Willmar, MN
Woodbury, MN
Ballwin, MO
Bolivar, MO
Creve Coeur, MO
Joplin, MO
Kansas City, MO
Lees Summit, MO
Saint Peters, MO
Springfield, MO
Springfield, MO
St. Joseph, MO
St. Louis, MO
St. Louis, MO
Billings, MT
Bozeman, MT
Great Falls, MT
Great Falls, MT
Kalispell, MT
Missoula, MT
Charlotte, NC
Grand Island, NE
Kearney, NE
Morristown, NJ
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Paradise, NV
Reno, NV
Glens Falls, NY
Boardman, OH
Centerville, OH
Chardon, OH
Chillicothe, OH
Cincinnati, OH
Cincinnati, OH
Cincinnati, OH
Cleveland, OH
Cleveland, OH
Cleveland, OH
Columbus, OH
Columbus, OH
Columbus, OH
Columbus, OH
Columbus, OH
Dayton, OH
Dayton, OH
Delaware, OH
Findlay, OH
Franklin, OH
Greenville, OH
Kettering, OH
Lima, OH
Marietta, OH
Mayfield Heights, OH
Mentor, OH
Middletown, OH
Newark, OH
Newark, OH
Portsmouth, OH
Sidney, OH
Springfield, OH
Toledo, OH
Toledo, OH
Toledo, OH
Westerville, OH
Whitehall, OH
Zanesville, OH
Oklahoma City, OK
Clackamas, OR
Coos Bay, OR
Newberg, OR
Portland, OR
Allentown, PA
Danville, PA
Hazleton, PA
Lewistown, PA
Pittsburgh, PA
Pottstown, PA
Pottsville, PA
West Reading, PA
Wilkes-Barre, PA
Salt Lake City, UT
Charlottesville, VA
Bellingham, WA
Bremerton, WA
Burien, WA
Edmonds, WA
Everett, WA
Longview, WA
Seattle, WA
Seattle, WA
Seattle, WA
Seattle, WA
Seattle, WA
Silverdale, WA
Walla Walla, WA
Yakima, WA
Ashland, WI
Burlington, WI
Eau Claire, WI
Fond Du Lac, WI
Grafton, WI
Green Bay, WI
Kenosha, WI
La Crosse, WI
Marshfield, WI
Milwaukee, WI
Milwaukee, WI
Milwaukee, WI
Minocqua, WI
Mount Pleasant, WI
Mukwonago, WI
New Richmond, WI
Oconomowoc, WI
Oconomowoc, WI
Oshkosh, WI
Rice Lake, WI
Sheboygan, WI
Stevens Point, WI
Two Rivers, WI
Wauwatosa, WI
West Allis, WI
Weston, WI
Morgantown, WV
Sheridan, WY
The following is a listing of trial locations that are not currently open and accepting patients.
Phoenix, AZ
Phoenix, AZ
Denver, CO
Denver, CO
Denver, CO
Durango, CO
Durango, CO
Grand Junction, CO
Lakewood, CO
Wheat Ridge, CO
Atlanta, GA
Council Bluffs, IA
Fort Dodge, IA
Jefferson, IA
Marshalltown, IA
Sandpoint, ID
Burr Ridge, IL
Melrose Park, IL
Orland Park, IL
Yorkville, IL
Indianapolis, IN
Overland Park, KS
Bardstown, KY
Corbin, KY
Louisville, KY
Shepherdsville, KY
Baton Rouge, LA
Springfield, MA
Ann Arbor, MI
Clinton Township, MI
Cambridge, MN
New Ulm, MN
Princeton, MN
Wyoming, MN
Washington, MO
Anaconda, MT
Billings, MT
Missoula, MT
Papillion, NE
Henderson, NV
Henderson, NV
Henderson, NV
Henderson, NV
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Las Vegas, NV
Spring Valley, NV
Belpre, OH
Columbus, OH
Dayton, OH
Forestville, OH
Lancaster, OH
Marion, OH
Mount Vernon, OH
White Oak, OH
State College, PA
Boiling Springs, SC
American Fork, UT
Murray, UT
Salt Lake City, UT
Enumclaw, WA
Federal Way, WA
Lakewood, WA
Puyallup, WA
Tacoma, WA
Waukesha, WI
Cheyenne, WY
Cody, WY
Anchorage, AK
Anchorage, AK
Anchorage, AK
Anchorage, AK
Anchorage, AK
Phoenix, AZ
Phoenix, AZ
Berkeley, CA
Burbank, CA
La Jolla, CA
Aurora, CO
Boulder, CO
Boulder, CO
Centennial, CO
Colorado Springs, CO
Colorado Springs, CO
Denver, CO
Denver, CO
Denver, CO
Denver, CO
Durango, CO
Durango, CO
Englewood, CO
Grand Junction, CO
Greeley, CO
Lakewood, CO
Lakewood, CO
Lakewood, CO
Littleton, CO
Lone Tree, CO
Longmont, CO
Longmont, CO
Loveland, CO
Parker, CO
Pueblo, CO
Thornton, CO
Wheat Ridge, CO
North Haven, CT
Orange, CT
Trumbull, CT
Fort Lauderdale, FL
Weston, FL
SparkCures Verified Accurate, up-to-date information. Learn more
Atlanta, GA
Savannah, GA
Boise, ID
Boise City, ID
Coeur d'Alene, ID
Fruitland, ID
Meridian, ID
Post Falls, ID
Sandpoint, ID
Twin Falls, ID
Aurora, IL
Burr Ridge, IL
Danville, IL
Effingham, IL
Geneva, IL
Harvey, IL
Mattoon, IL
Melrose Park, IL
Mount Vernon, IL
Niles, IL
Orland Park, IL
Urbana, IL
Warrenville, IL
Yorkville, IL
Ames, IA
Ames, IA
Boone, IA
Clive, IA
Council Bluffs, IA
Creston, IA
Des Moines, IA
Des Moines, IA
Des Moines, IA
Fort Dodge, IA
Jefferson, IA
Marshalltown, IA
West Des Moines, IA
West Des Moines, IA
Overland Park, KS
Bardstown, KY
Corbin, KY
Lexington, KY
Louisville, KY
Louisville, KY
Louisville, KY
Louisville, KY
Shepherdsville, KY
Baton Rouge, LA
Baton Rouge, LA
Jefferson, LA
New Orleans, LA
Baltimore, MD
Boston, MA
Springfield, MA
Ann Arbor, MI
Battle Creek, MI
Brighton, MI
Canton, MI
Caro, MI
Chelsea, MI
Clinton Township, MI
Dearborn, MI
Detroit, MI
Flint, MI
Flint, MI
Grand Rapids, MI
Grand Rapids, MI
Grand Rapids, MI
Jackson, MI
Kalamazoo, MI
Kalamazoo, MI
Kalamazoo, MI
Lansing, MI
Livonia, MI
Muskegon, MI
Niles, MI
Novi, MI
Pontiac, MI
Reed City, MI
Saginaw, MI
Saginaw Valley, MI
St. Joseph, MI
St. Joseph, MI
Tawas City, MI
Traverse City, MI
West Bloomfield, MI
Ypsilanti, MI
Brainerd, MN
Burnsville, MN
Cambridge, MN
Coon Rapids, MN
Deer River, MN
Duluth, MN
Duluth, MN
Edina, MN
Fergus Falls, MN
Fridley, MN
Hibbing, MN
Maple Grove, MN