A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma TTI-622

What's the purpose of this trial?

The goal of this clinical trial is to find the best dose and learn more about the safety and effectiveness of maplirpacept (PF-07901801) in patients with advanced hematologic malignancies, including Lymphoma, Leukemia, and Multiple Myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

This trial is being conducted in two phases, 1a and 1b. During Phase 1a, researchers gave participants different doses of maplirpacept (PF-07901801) to determine which dose is best tolerated. During Phase 1b, researchers will give the best doses of maplirpacept (PF-07901801) from Phase 1a, alone or in combination with other medicines, to a larger group of participants to further evaluate its safety and effectiveness. 

This trial is open-label, which means that both participants and researchers will know which group they are placed in, and what treatments and doses they are receiving. Participants in this study may continue to receive study treatment unless they develop bad side effects, or their cancer gets worse. 

Phase 1b of this trial is further separated into smaller groups, called cohorts. The cohort of this trial you may join depends on your diagnosis and other factors. 

Reimbursement for study-related travel expenses may be available.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

• have measurable disease as defined by the trial criteria. The measurable disease criteria depends on your diagnosis, and which specific cohort you may qualify for. 
• do not have central nervous system involvement of your cancer.
• have not received a stem cell transplant in the last 90 days. 
• have not previously received treatment with an anti-CD47 and anti-SIRPa therapy.
• are not refractory to or intolerant to anti-CD38 therapy, and have not received anti-CD38 therapy in the previous 60 days. 

Additional Trial Information

Phase 1

Enrollment: 476 patients (estimated)

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Trial Locations

All Trial Locations

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USC Norris Comprehensive Cancer Center University of Southern California

Los Angeles, CA

Open and Accepting



Christiana Care Health System (Christiana Hospital)

Newark, DE

Not Yet Accepting

ChristianaCare Helen F. Graham Cancer Center Christiana Hospital

Newark, DE

Not Yet Accepting


Tampa General Hospital Cancer Institute

Tampa, FL

Open and Accepting


Northside Hospital (Atlanta)

Atlanta, GA

Open and Accepting


Franciscan Health Cancer Center Indianapolis

Indianapolis, IN

Open and Accepting


Norton Cancer Institute (St. Matthews) St. Matthews Campus

Louisville, KY

Open and Accepting


University of Michigan Comprehensive Cancer Center Rogel Cancer Center

Ann Arbor, MI

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Roswell Park Cancer Institute

Buffalo, NY

Open and Accepting

Montefiore Medical Center (Moses Campus)

New York, NY

Open and Accepting

North Carolina

Novant Health Presbyterian Medical Center Novant Health

Charlotte, NC

Open and Accepting

Novant Health Forsyth Medical Center - Silas Creek

Winston-Salem, NC

Open and Accepting


Thomas Jefferson University Hospital

Philadelphia, PA

Open and Accepting

West Penn Hospital (Allegheny Health Network)

Pittsburgh, PA

Open and Accepting

South Carolina

Prisma Health - Greenville Memorial Hospital

Greenville, SC

Not Yet Accepting


University of Tennessee Medical Center Cancer Institute

Knoxville, TN

Open and Accepting


MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting


Swedish - Cherry Hill Campus Cherry Hill Campus

Seattle, WA

Open and Accepting

Washington, D.C.

Georgetown Lombardi Comprehensive Cancer Center Georgetown University

Washington, DC

Open and Accepting
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