Elranatamab (PF-06863135) is a B-cell Maturation Antigen (BCMA)-CD3 bispecific antibody being tested in multiple myeloma.
View all active clinical trials around the US.
The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.
The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.
June 09, 2021
Doses at or above 215 μg/kg had the best outcomes, with an overall response rate (ORR) of 70% (n = 14). Out of the 215-, 360-, 600-, and 1000-μg/kg dose groups, the highest dose had the best outcomes, with an 83.3% ORR, including 16.7% of patients with a complete response, 50% with a very good complete response, and 16.7% with a partial response. Median time to response was 22 days, ranging from 21 to 50 days.
There were 14 patients with IMWG-confirmed response; in this cohort, median duration of response was not reached. There was a 92.3% probability (95% CI, 56.7-98.9) of responders being event-free at 6 months.
Within the entire study population, the most common all causality treatment-emergent adverse events (AEs) were
There were no dose-limiting toxicities.