Phase 1/2 Clinical Trial Evaluating the Safety, Effectiveness and Best Dose of Elranatamab Combined with Different Anti-Cancer Therapies in Participants with Multiple Myeloma MAGNETISMM-4

What's the purpose of this trial?

The goal of this clinical trial is to evaluate the best dose, safety and effectiveness of elranatamab when combined with different anti-cancer therapies in participants with multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

This clinical trial is being conducted in several different sub-studies. This trial is open-label, which means that participants and the study team will know which part participants are enrolled in, and which drugs / doses they will be receiving. Two sub-studies are currently open and enrolling participants.

After the end of the study, researchers may ask you to have monthly follow up visits, or telephone calls with the study team every few months.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have measurable multiple myeloma as determined by the trial protocol.
  • have multiple myeloma that is refractory to at least one immunomodulatory drug, one proteasome inhibitor, and one anti-CD-38 antibody.
  • do not have primary refractory multiple myeloma.
  • have received at least three prior lines of therapy for multiple myeloma.
  • have not previously received either an anti-BCMA bispecific antibody or any kind of therapy targeting BCMA depending on the sub-study currently open (BCMA is the target of the combination of drugs tested against multiple myeloma).
  • have adequate heart, liver, kidney and bone marrow function as described in the trial criteria.

Additional Trial Information

Phase 1/2

Enrollment: 370 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.


Banner MD Anderson Cancer Center at Banner Gateway Medical Center

Gilbert, AZ

Open and Accepting


University of Arkansas for Medical Sciences (UAMS)

Little Rock, AR

Open and Accepting


Beverly Hills Cancer Center

Beverly Hills, CA

Open and Accepting



University of Chicago Medicine Comprehensive Cancer Center

Chicago, IL

Open and Accepting



University of Kansas Cancer Center

Kansas City, KS

Open and Accepting


Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Open and Accepting


Massachusetts General Hospital

Boston, MA

Open and Accepting

Beth Israel Deaconess Medical Center

Boston, MA

Open and Accepting


Nebraska Medicine (Bellevue Medical Center)

Bellevue, NE

Not Yet Accepting

Nebraska Medicine (Village Pointe)

Omaha, NE

Not Yet Accepting

Nebraska Medicine (Nebraska Medical Center)

Omaha, NE

Not Yet Accepting


Seattle Cancer Care Alliance SCCA

Seattle, WA

Not Yet Accepting
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