Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Elranatamab VS Lenalidomide in Participants with Newly Diagnosed Multiple Myeloma Who Have Had an Autologous Stem Cell Transplant MAGNETISMM-7
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What's the purpose of this trial?

The goal of this clinical trial is to compare the safety and effectiveness of Elranatamab versus Lenalidomide in participants with newly diagnosed multiple myeloma who have recently undergone autologous stem cell transplant. 

This trial is currently open and accepting patients.

What will happen during the trial?

This study is being conducted in three different parts (or arms). The two arms in this study that are open for enrollment are Arms B and C. Arm A is no longer open for patient enrollment. In Arm B, participants will receive Lenalidomide as maintenance therapy, and in Arm C participants will receive Elranatamab as maintenance therapy.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • Have measurable disease as defined by the trial criteria.
  • Have had 3-8 cycles of induction therapy followed by high dose chemotherapy and autologous stem cell transplant for newly diagnosed multiple myeloma. Your stem cell transplant must have been in the last 120 days before joining this trial. For patients who are receiving consolidation (or maintenance) therapy after their transplant, you must join this trial within 60 days of consolidation therapy, and within 7 months from transplant.
  • Do not have known or active central nervous system involvement of your myeloma.
  • Have not previously had treatment with maintenance therapy for your myeloma.
  • Have not previously had treatment with a BCMA targeted therapy.

Additional Trial Information

Phase 3

Enrollment: 760 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Arizona

Banner MD Anderson Cancer Center at Banner Gateway Medical Center

Gilbert, AZ

Open and Accepting

California

UCLA Jonsson Comprehensive Cancer Center University of California Los Angeles

Los Angeles, CA

Open and Accepting

Florida

Miami Cancer Institute Baptist Health South Florida

Miami, FL

Open and Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Open and Accepting

Michigan

University of Michigan Comprehensive Cancer Center Rogel Cancer Center

Ann Arbor, MI

Open and Accepting

Mississippi

University of Mississippi Medical Center

Jackson, MS

Open and Accepting

Missouri

Alliance for Multi-Specialty Research

Kansas City, MO

Open and Accepting

New Jersey

John Theurer Cancer Center at Hackensack University Medical Center  Hackensack Meridian Health

Hackensack, NJ

Open and Accepting

Ohio

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Open and Accepting

OhioHealth Riverside Methodist Hospital

Columbus, OH

Open and Accepting
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