The following criteria is provided for health care professionals.

Inclusion Criteria:

• Eastern Collaborative Oncology Group (ECOG) performance score of less than or equal to 2.
• Documented relapsed or progressive Multiple Myeloma (MM) on or after any regimen or is refractory to the most recent line of therapy.
• Received prior treatment with at least 1, but no more than 3, prior lines of therapy for MM.
• Measurable disease on Screening per International Myeloma Working Group (IMWG) criteria.
• Meets absolute neutrophil count, platelet count, hemoglobin, liver and kidney function laboratory values within 2 weeks prior to first dose of study drug.
• For Part 3, Cohort 7, participants must meet the above criteria and also be positive for translocation t(11;14) as determined by an analytically validated Fluorescent In Situ Hybridization (FISH) assay per central laboratory testing.

Exclusion Criteria:

• Has a pre-existing condition that is contraindicated including
• Non-secretory or oligo-secretory MM
• Active plasma cell leukemia
• Waldenström's macroglobulinemia
• Primary amyloidosis
• POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)
• Active hepatitis B or C infection based on screening blood testing
• Significant cardiovascular disease
• Major surgery within 4 weeks prior to first dose
• Acute infections requiring parenteral therapy
• Peripheral neuropathy ≥ Grade 3 or ≥ Grade 2 with pain within 2 weeks prior to first dose
• Uncontrolled diabetes or uncontrolled hypertension within 14 days prior to first dose
• Any other medical condition that, in the opinion of the Investigator, would adversely affect the subject's participation in the study.
• History of other active malignancies, including myelodysplastic syndrome (MDS), within the past 3 years prior to study entry Other protocol defined inclusion/exclusion criteria could apply