Venetoclax

Overview

Venetoclax is a type of drug called a Bcl-2 inhibitor. The Bcl-2 protein is found on some cancer cells, and helps them survive, sometimes making them more resistant to treatment. Venetoclax works by blocking the action of the Bcl-2 protein, which may help to cause cancer cell death.

SparkCures ID 24
Developed By AbbVie
Generic Name Venetoclax
Additional Names ABT-199
Treatment Classifications

Clinical Trials

All Clinical Trials

View all active clinical trials around the US.

Early Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.

Verified
Phase 3 Clinical Trial comparing the use of venetoclax combined with dexamethasone versus Pomalidomide combined with dexamethasone in Relapsed/Refractory Mul...
CANOVA
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Verified
Phase 2 Clinical Trial Evaluating the Safety, Tolerability, and Effectiveness of Venetoclax combined with Carfilzomib and Dexamethasone in Relapsed/Refractor...
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Verified
Phase 1/2 clinical trial evaluating the safety and tolerability of venetoclax combined with daratumumab and dexamethasone with or without bortezomib in relap...
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SparkCures Verified Accurate, up-to-date information. Learn more

Myeloma-Developing Regimens Using Genomics
MYDRUG
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Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
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Study of AZD5991 in Relapsed or Refractory Haematologic Malignancies
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Late Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.

Verified
Phase 3 Clinical Trial comparing the use of venetoclax combined with dexamethasone versus Pomalidomide combined with dexamethasone in Relapsed/Refractory Mul...
CANOVA
View Trial
Verified
Phase 2 Clinical Trial Evaluating the Safety, Tolerability, and Effectiveness of Venetoclax combined with Carfilzomib and Dexamethasone in Relapsed/Refractor...
View Trial
Verified
Phase 1/2 clinical trial evaluating the safety and tolerability of venetoclax combined with daratumumab and dexamethasone with or without bortezomib in relap...
View Trial

SparkCures Verified Accurate, up-to-date information. Learn more

Myeloma-Developing Regimens Using Genomics
MYDRUG
View Trial
Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
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Study of AZD5991 in Relapsed or Refractory Haematologic Malignancies
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Smoldering Myeloma
Monoclonal Gammopathy of Undetermined Significance (MGUS)

Published Results

Phase III BELLINI: Updated Results With Venetoclax or Placebo Plus Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma

May 31, 2020

  • Venetoclax added to Vd significantly improved PFS, ORR, and MRD negative rates in patients with R/R multiple myeloma but was associated with worse OS outcomes
  • Increased incidence of deaths attributed to infections
  • (11;14) cytogenetic marker associated with favorable risk-benefit profile for survival outcomes with venetoclax + Vd combination
  • Investigators conclude that the results support a t(11;14) biomarker-driven approach for venetoclax development in R/R multiple myeloma
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Resources

Phase III Study With Venetoclax Combo Identifies New Biomarker for Relapsed/Refractory Myeloma

December 11, 2019

The phase III BELLINI trial (NCT02755597) demonstrated translocation(t)(11;14) and high BCL2 gene expression are predictive of response to treatment with the addition of venetoclax (Venclexta) to bortezomib (Velcade) plus dexamethasone in patients with relapsed/refractory multiple myeloma, according to the findings presented at the 2019 American Society of Hematology (ASH) Annual Meeting.
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Partial Clinical Hold Lifted for One Venetoclax Trial in Multiple Myeloma

June 24, 2019

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ASCO 2019: Venetoclax Updates with Mike Thompson, MD, PhD, Advocate Aurora Health

June 18, 2019

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The Confounding Case of Venetoclax in Multiple Myeloma

May 16, 2019

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FDA Halts Enrollment on Venetoclax Myeloma Trials

March 19, 2019

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