ABT-199 is an anti-apoptotic protein Bcl-2 inhibitor that mimics BH3-only proteins, the native ligands of Bcl-2 and programmed cell death activators, repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.
March 19, 2019 The FDA has placed a partial clinical hold on all clinical trials examining venetoclax (Venclexta) in multiple myeloma, halting enrollment of new patients on the studies, according to AbbVie, which jointly develops the BCL-2 inhibitor with Genentech (Roche). Read more...
| SparkCures ID | 24 |
|---|---|
| Developed By | AbbVie |
| Generic Name | Venetoclax |
| Additional Names | ABT-199 |
| Treatment Classifications |
View all active clinical trials around the US.
The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.
The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.
December 11, 2019
The phase III BELLINI trial (NCT02755597) demonstrated translocation(t)(11;14) and high BCL2 gene expression are predictive of response to treatment with the addition of venetoclax (Venclexta) to bortezomib (Velcade) plus dexamethasone in patients with relapsed/refractory multiple myeloma, according to the findings presented at the 2019 American Society of Hematology (ASH) Annual Meeting.
March 19, 2019
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