S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

DRAMMATIC

Overview

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Step 3) to either continue or discontinue the assigned treatment. Patients are treated for up to 7 years from Step 2 reg and followed for up to 15 years.

SparkCures ID 1019
Trial Phase Phase 3
Enrollment 1100 Patients
Treatments
Tags
Trial Sponsors
  • Southwest Oncology Group
Trial Collaborators
  • National Cancer Institute (NCI)
  • Janssen Research & Development
  • Adaptive Biotechnologies
NCT Identifier

NCT04071457

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Registration Step 1 Except where otherwise indicated below that test is required in a shorter timeframe, all tests for establishing baseline disease status must be completed within 60 days prior to registration. All test results must be documented on the Baseline Tumor Assessment Form for Multiple Myeloma and the Onstudy Form.

Inclusion Criteria

  • Patients must have had a confirmed diagnosis of symptomatic multiple myeloma (See Section 4.1) that required systemic induction therapy prior to autologous stem cell transplantation (ASCT).
  • Patients with disease measurable by serum light chain assay alone are eligible (defined as >/= 100 mg/L on involved light chain).
  • Patients must be registered to Step 1 prior to registration to Step 2. Registration to Step 1 may take place prior to or after autologous stem cell transplant (ASCT), but after completion of induction therapy.
  • Patients must have initiated induction therapy within 12 months prior to registration Step 1 and have received at least two cycles of induction therapy.
  • Patients must be willing and able to take DVT prophylaxis (aspirin, low molecular weight heparin, warfarin, or equivalent oral anticoagulation).
  • Patients must be >/= 18 and
  • Patients must have history and physical exam within 28 days prior to registration.
  • Patients must have Zubrod Performance Status
  • Patients must have evidence of adequate renal function, as defined by (1) creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or (2) serum creatinine < 2.5 mg/dL. Values must be obtained within 28 days prior to registration.
  • Patients must have adequate hepatic function defined by the following within 42 days prior to registration:
    • Total bilirubin
    • AST and ALT
  • Patients must meet one of the following criteria:
    • Be acceptable for transplant per institutional guidelines and the criteria evidencing this must be documented on the S1803 Onstudy Form. (See Appendix 18.3 for standard transplant eligibility guidelines. Note that these are guidelines and not required criteria.) OR
    • Have completed autologous stem cell transplant within 180 days prior to registration (see also Section 5.2a).
  • Patient's with human immunodeficiency virus (HIV) are eligible providing they are on effective antiretroviral therapy and have undetectable viral load at their most previous viral load test and within 6 months prior to registration.
  • Patients must be able to take and swallow oral medication (capsules) whole. Patients may not have any known impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drug (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).
  • For patients who have not yet received transplant: Patients must be willing and able to return to the transplant center for their assigned treatment after randomization. Note that patients need not have a direct relationship with the transplant center in order to register.
  • Patients must submit specimens for MRD as outlined in Section 15.1. See Section 15.1 for further information, including specimen submission timepoints. Note that patients are not ineligible based solely on archival specimens being unavailable.
  • Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted as outlined in Section 15.2.
  • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
  • As a part of the OPEN registration process (see Section 13.3 for OPEN access instructions) the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

Exclusion Criteria

  • Patients with smoldering myeloma are not eligible. Patients with purely non-secretory MM as measured by electrophoresis and immunofixation and the absence of Bence Jones proteins in the urine are not eligible. Patients must have measurable M protein in the serum (defined as >/= 0.5g/dL) or urine (defined as >/= 200 mg/24h). Patients with plasma cell leukemia are not eligible.
  • Patients must not have any organ involvement by amyloidosis or evidence of amyloidosis related organ dysfunction.
  • Patients must not have progressive disease at any time prior to registration.
  • Patients must not be refractory to either lenalidomide or daratumumab/rHuPH20.
  • Patients must not be intolerant to either lenalidomide or daratumumab/rHuPH20.
  • Patients must not have received any investigational agents within 14 days prior to registration.
  • Patients must not have chronic obstructive pulmonary disease with a forced expiratory volume in 1 second (FEV1) < 50% of predicted normal. FEV1 is required for patients suspected of having chronic obstructive pulmonary disease and are not eligible if FEV1 is < 50% of predicted normal.
  • Patients must not have moderate or severe persistent asthma within the past 2 years and must not have currently uncontrolled asthma of any classification.
  • Patients must not have had prior autograft or allograft, or prior organ transplant requiring immunosuppressive therapy.
  • Patients must not have known allergy to any of the study drugs.
  • Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progression or no clinical improvement) at time of enrollment are not eligible.
  • Patients must not have known central nervous system (CNS) involvement with multiple myeloma, defined as CSF positivity for plasma cells at any time or a parenchymal CNS plasmacytoma at time of enrollment. Lumbar puncture is not required.
  • Patients must not be seropositive for hepatitis C (except in the setting of sustained virologic response, defined as undetectable viral load at least 12 weeks after completion of antiviral therapy). HCV testing is only required if clinically indicated or if the patient has a history of HCV.
  • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.
  • Patients must not have any uncontrolled intercurrent illness including (not limited to): Symptomatic CHF (NYHA III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration, Unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI CTCAE v5.0 Grade >/= 2), intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>/= Grade 3), or known psychiatric illness that would limit study compliance.

Registration Step 2 - First Randomization (Post-ASCT, Pre-Maintenance)

Inclusion Criteria:

  • Patients must have completed ASCT within 180 days prior to registering to Step 2.
  • Patients must have one of the following performed within 60 days prior to registration for disease assessment: diagnostic quality skeletal survey, whole body CT scan, MRI, or PET.
  • Patients must have Zubrod Performance Status
  • Patients must have adequate bone marrow function as evidenced by platelets >/= 75,000/mm3 and ANC >/= 1,000/mm3 within 28 days prior to first randomization:
  • Patients must have adequate hepatic function defined by the following within 28 days prior to first randomization:
  • Total bilirubin
  • Patients must have evidence of adequate renal function, as defined by creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or have a serum creatinine < 2.5 mg/dL within 28 days prior to first randomization.
  • All ASCT-related toxicities must have recovered to
  • Mucositis and gastrointestinal symptoms must have resolved to
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to registration.
  • FCBP must agree to have a second pregnancy test within 24 hours prior to starting Cycle 1. Further, FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide. FCBP must also agree to ongoing pregnancy testing and must agree to not become pregnant for at least 3 months after the last dose of study treatment.
  • Men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy, during the study treatment and for 3 months after the last dose of study treatment.
  • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

Exclusion Criteria:

  • Patients must not have received any other maintenance therapy post-ASCT and prior to Step 2 registration.
  • Patients must not have had progressive disease between induction and registration to Registration Step 2. (See Section 10.1b).

Registration Step 3 - Second Randomization (Post 24 Months Maintenance)

Inclusion Criteria:

  • Patients must have completed 24 cycles of protocol maintenance with either lenalidomide or lenalidomide + daratumumab/rHuPH20.
  • Patients must have 24-month MRD by NGS test results available and must be MRD negative. Patients whose PCR results are indeterminable will be considered to have positive results.
  • Patients must be in very good partial remission (VGPR) or better by IMWG response criteria (see Section 10.1b).

US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

SparkCures Verified Accurate, up-to-date information. Learn more


Alaska Women's Cancer Care

Anchorage, AK

Anchorage Oncology Centre

Anchorage, AK

Katmai Oncology Group

Anchorage, AK

Providence Alaska Medical Center

Anchorage, AK

St. Edward Mercy Medical Center

Fort Smith, AR

Kaiser Permanente (Antioch Medical Center)

Antioch, CA

Roy and Patricia Disney Family Cancer Center Providence Saint Joseph Medical Center

Burbank, CA

Kaiser Permanente (Fremont Medical Center)

Fremont, CA

Kaiser Permanente (Fresno Medical Center)

Fresno, CA

Rideout Cancer Center (Fremont)

Linda, CA

Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Los Angeles, CA

Kaiser Permanente (Modesto Medical Center)

Modesto, CA

Kaiser Permanente (Oakland Medical Center)

Oakland, CA

Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

Kaiser Permanente (Richmond Medical Center)

Richmond, CA

Kaiser Permanente (Roseville Medical Center)

Roseville, CA

Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (San Francisco Medical Center)

San Francisco, CA

Kaiser Permanente (San Jose Medical Center)

San Jose, CA

Kaiser Permanente (San Leandro Medical Center)

San Leandro, CA

Kaiser Permanente (San Rafael Medical Center)

San Rafael, CA

Kaiser Permanente (Santa Clara Medical Center)

Santa Clara, CA

Mission Hope Cancer Center

Santa Maria, CA

Kaiser Permanente (Santa Rosa Medical Center)

Santa Rosa, CA

Kaiser Permanente (South San Francisco Medical Center)

South San Francisco, CA

Kaiser Permanente (Stockton Medical Center)

Stockton, CA

Tahoe Forest Cancer Center

Truckee, CA

Kaiser Permanente (Vacaville Medical Center)

Vacaville, CA

Kaiser Permanente (Vallejo Medical Center)

Vallejo, CA

Kaiser Permanente (Walnut Creek Medical Center)

Walnut Creek, CA

Littleton Adventist Hospital

Centennial, CO

Penrose-Saint Francis Healthcare

Colorado Springs, CO

Rocky Mountain Cancer Center Colorado Springs

Colorado Springs, CO

Kaiser Permanente (Franklin)

Denver, CO

Porter Adventist Hospital

Denver, CO

Mercy Medical Center

Durango, CO

Southwest Oncology PC

Durango, CO

Kaiser Permanente (Rock Creek)

Lafayette, CO

Saint Anthony Hospital

Lakewood, CO

Kaiser Permanente Lone Tree Medical Offices

Lone Tree, CO

Longmont United Hospital

Longmont, CO

Rocky Mountain Cancer Center Longmont

Longmont, CO

Parker Adventist Hospital

Parker, CO

Saint Mary Corwin Medical Center

Pueblo, CO

Delaware Clinical and Laboratory Physicians PA

Brookside, DE

Helen F. Graham Cancer Center

Brookside, DE

Medical Oncology Hematology Consultants PA

Brookside, DE

Beebe Medical Center

Lewes, DE

Christiana Care Health System (Christiana Hospital)

Newark, DE

Beebe Health Campus

Rehoboth Beach, DE

Nanticoke Memorial Hospital

Seaford, DE

Christiana Care Health System (Wilmington Hospital)

Wilmington, DE

Advent Health Medical Group Blood & Marrow Transplant

Orlando, FL

Northside Hospital

Atlanta, GA

Queen's Medical Center

Honolulu, HI

Straub Clinic and Hospital

Honolulu, HI

University of Hawaii Cancer Center

Honolulu, HI

Kuakini Medical Center

Honolulu, HI

Kaiser Permanente (Moanalua Medical Center)

Honolulu, HI

Kapiolani Medical Center for Women and Children

Honolulu, HI

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, HI

Mary Greeley Medical Center

Ames, IA

McFarland Clinic PC

Ames, IA

McFarland Clinic PC (Boone)

Boone, IA

McFarland Clinic PC (Trinity Cancer Center)

Fort Dodge, IA

McFarland Clinic PC (Jefferson)

Jefferson, IA

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Mercy Medical Center (West Lakes)

West Des Moines, IA

St. Luke's Regional Medical Center - Mountain States Tumor Institute (Boise)

Boise, ID

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Kootenai Medical Center

Coeur dAlene, ID

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

Saint Luke's Mountain States Tumor Institute (Meridian)

Meridian, ID

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Kootenai Cancer Center

Post Falls, ID

Kootenai Clinic

Sandpoint, ID

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Illinois CancerCare (Bloomington)

Bloomington, IL

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Illinois CancerCare (Canton)

Canton, IL

Memorial Hospital of Carbondale

Carbondale, IL

SIH Cancer Institute

Carterville, IL

Illinois CancerCare (Carthage)

Carthage, IL

Centralia Oncology Clinic

Centralia, IL

Cancer Care Specialists of Central Illinois

Decatur, IL

Decatur Memorial Hospital

Decatur, IL

Illinois CancerCare-Dixon

Dixon, IL

Crossroads Cancer Center

Effingham, IL

Illinois CancerCare (Eureka)

Eureka, IL

Illinois CancerCare (Galesburg)

Galesburg, IL

Western Illinois Cancer Treatment Center

Galesburg, IL

Illinois CancerCare (Kewanee)

Kewanee, IL

Illinois CancerCare (Macomb)

Macomb, IL

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Good Samaritan Regional Health Center

Mount Vernon, IL

Loyola Center for Cancer Care and Research

Orland Park, IL

Illinois CancerCare (Ottawa)

Ottawa, IL

Illinois CancerCare (Pekin)

Pekin, IL

Illinois CancerCare

Peoria, IL

Methodist Medical Center of Illinois

Peoria, IL

Illinois CancerCare (Peru)

Peru, IL

Valley Radiation Oncology

Peru, IL

Illinois CancerCare (Princeton)

Princeton, IL

Southern Illinois University School of Medicine

Springfield, IL

Springfield Clinic

Springfield, IL

Memorial Medical Center

Springfield, IL

Cancer Care Specialists of Illinois (Swansea)

Swansea, IL

Flaget Memorial Hospital

Bardstown, KY

Commonwealth Cancer Center (Corbin)

Corbin, KY

Saint Joseph Hospital

Lexington, KY

Saint Joseph Hospital East

Lexington, KY

Jewish Hospital

Louisville, KY

KentuckyOne Health - James Graham Brown Cancer Center

Louisville, KY

Saints Mary and Elizabeth Hospital

Louisville, KY

Jewish Hospital Medical Center Northeast

Louisville, KY

Jewish Hospital Medical Center South

Shepherdsville, KY

Hematology Oncology Clinic

Baton Rouge, LA

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Boston Medical Center

Boston, MA

Lahey Hospital and Medical Center

Burlington, MA

University of Massachusetts Medical School

Worcester, MA

Eastern Maine Medical Center

Bangor, ME

Lafayette Family Cancer Center

Brewer, ME

Bronson Battle Creek Cancer Care Center

Battle Creek, MI

Weisberg Cancer Treatment Center

Farmington Hills, MI

Michigan State University (McLaren Regional Medical Center)

Flint, MI

Mercy Health Saint Mary's

Grand Rapids, MI

Spectrum Health

Grand Rapids, MI

Bronson Methodist Hospital

Kalamazoo, MI

West Michigan Cancer Center

Kalamazoo, MI

Borgess Medical Center

Kalamazoo, MI

Mercy Health Mercy Campus

Muskegon Heights, MI

Lakeland Community Hospital

Niles, MI

Spectrum Health Reed City Hospital

Reed City, MI

Lakeland Hospital

Saint Joseph, MI

Marie Yeager Cancer Center

Saint Joseph, MI

Munson Medical Center

Traverse City, MI

Essentia Health Saint Joseph's Medical Center

Brainerd, MN

Fairview Ridges Hospital

Burnsville, MN

Cambridge Medical Center

Cambridge, MN

Mercy Hospital

Coon Rapids, MN

Essentia Health

Deer River, MN

Essentia Health Duluth Clinic CCOP

Duluth, MN

Essentia Health Saint Mary's Medical Center

Duluth, MN

Essentia Health (Miller-Dwan Building)

Duluth, MN

Fairview Southdale Hospital

Edina, MN

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Unity Hospital

Fridley, MN

Essentia Health Hibbing Clinic

Hibbing, MN

Fairview Maple Grove Medical Center

Maple Grove, MN

Minnesota Oncology and Hematology PA (Maplewood)

Maplewood, MN

Saint John's Hospital - Healtheast

Maplewood, MN

Abbott-Northwestern Hospital

Minneapolis, MN

Hennepin County Medical Center

Minneapolis, MN

Health Partners Inc.

Minneapolis, MN

Monticello Cancer Center

Monticello, MN

New Ulm Medical Center

New Ulm, MN

Fairview Northland Medical Center

Princeton, MN

North Memorial Medical Health Center

Robbinsdale, MN

Mayo Clinic (Rochester)

Rochester, MN

Saint Francis Regional Medical Center

Shakopee, MN

Park Nicollet Clinic (Saint Louis Park)

St. Louis Park, MN

Park Nicollet Institute (Louisiana Avenue)

St. Louis Park, MN

Regions Hospital

St. Paul, MN

United Hospital

St. Paul, MN

Lakeview Hospital

Stillwater, MN

Essentia Health Virginia Clinic

Virginia, MN

Ridgeview Medical Center

Waconia, MN

Rice Memorial Hospital

Willmar, MN

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Fairview Lakes Medical Center

Wyoming, MN

Saint Louis Cancer and Breast Institute

Ballwin, MO

Parkland Health Center (Bonne Terre)

Bonne Terre, MO

CoxHealth Cancer Center

Branson, MO

Saint Francis Medical Center (Cape Girardeau)

Cape Girardeau, MO

Southeast Cancer Center

Cape Girardeau, MO

Siteman Cancer Center at West County Hospital

Creve Coeur, MO

Mercy Hospital Saint Louis

Creve Coeur, MO

Capital Region Medical Center (Goldschmidt Cancer Center)

Jefferson City, MO

Freeman Health System

Joplin, MO

Phelps County Regional Medical Center

Rolla, MO

Saint John's Clinic-Rolla-Cancer and Hematology

Rolla, MO

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, MO

Mercy Hospital Springfield

Springfield, MO

CoxHealth South Hospital

Springfield, MO

St. Joseph Oncology

St. Joseph, MO

Heartland Regional Medical Center

St. Joseph, MO

Saint Louis Cancer and Breast Institute (South City)

St. Louis, MO

Mercy Hospital South

St. Louis, MO

Siteman Cancer Center South County

St. Louis, MO

Missouri Baptist Medical Cancer Center

St. Louis, MO

Missouri Baptist Sullivan Hospital

Sullivan, MO

Missouri Baptist Outpatient Center (Sunset Hills)

Sunset Hills, MO

Mercy Hospital Washington

Washington, MO

Community Hospital of Anaconda

Anaconda, MT

Bozeman Deaconess Hospital

Bozeman, MT

Benefis Healthcare (Sletten Cancer Institute)

Great Falls, MT

Great Falls Clinic

Great Falls, MT

Kalispell Regional Medical Center

Kalispell, MT

Saint Patrick Hospital - Community Hospital

Missoula, MT

Community Medical Hospital

Missoula, MT

Southeastern Medical Oncology Center (Clinton)

Clinton, NC

Southeastern Medical Oncology Center (Goldsboro)

Goldsboro, NC

Southeastern Medical Oncology Center (Jacksonville)

Jacksonville, NC

FirstHealth of the Carolinas (Moore Regional Hosiptal)

Pinehurst, NC

First Health Outpatient Cancer Center

Pinehurst, NC

Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

CHI Health Saint Francis Medical Center

Grand Island, NE

CHI Health Good Samaritan Hospital

Kearney, NE

Saint Elizabeth Regional Medical Center

Lincoln, NE

Methodist Hospital Nebraska Methodist Health System

Omaha, NE

CHI Health Creighton University Medical Center

Omaha, NE

CHI Health Midlands

Papillion, NE

Valley Medical Group

Paramus, NJ

Valley Health System The Daniel and Gloria Blumenthal Cancer

Paramus, NJ

University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

NewYork-Presbyterian/ Weill Cornell Medical Center

New York, NY

Rochester General Hospital

Rochester, NY

University of Rochester Medical Center James P. Wilmot Cancer Center

Rochester, NY

Strecker Cancer Center (Belpre)

Belpre, OH

Bethesda North Hospital

Blue Ash, OH

Adena Regional Medical Center

Chillicothe, OH

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Case Western Reserve University

Cleveland, OH

Cleveland Clinic (Fairview Hospital)

Cleveland, OH

Mount Carmel Health Center West

Columbus, OH

Columbus Oncology and Hematology Associates Inc

Columbus, OH

Riverside Methodist Hospital

Columbus, OH

Grant Medical Center

Columbus, OH

The Mark H. Zangmeister Center

Columbus, OH

Doctors Hospital

Columbus, OH

Dayton Physicians (Miami Valley Hospital South)

Dayton, OH

Miami Valley Hospital

Dayton, OH

Miami Valley Hospital (South)

Dayton, OH

Oncology Hematology Care Inc. (Kenwood)

Deer Park, OH

Delaware Health Center (Grady Cancer Center)

Delaware, OH

Grady Memorial Hospital

Delaware, OH

Blanchard Valley Hospital

Findlay, OH

TriHealth Cancer Institute (Anderson)

Forestville, OH

Atrium Medical Center (Middletown Regional Hospital)

Franklin, OH

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Dayton Physicians (Wilson Memorial Hospital)

Greenville, OH

Wayne Hospital

Greenville, OH

Kettering Medical Center

Kettering, OH

Fairfield Medical Center

Lancaster, OH

Cleveland Clinic (Mansfield)

Mansfield, OH

Marietta Memorial Hospital

Marietta, OH

OhioHealth Marion General Hospital

Marion, OH

Cleveland Clinic (Hillcrest Hospital)

Mayfield Heights, OH

Knox Community Hospital

Mount Vernon, OH

Licking Memorial Hospital

Newark, OH

Newark Radiation Oncology

Newark, OH

Southern Ohio Medical Center

Portsmouth, OH

Cleveland Clinic (North Coast Cancer Care)

Sandusky, OH

Cleveland Clinic (Strongsville Family Health and Surgery Center)

Strongsville, OH

Dayton Physicians (Upper Valley Medical Center)

Troy, OH

Upper Valley Medical Center

Troy, OH

Saint Ann's Hospital

Westerville, OH

TriHealth Cancer Institute (Westside)

White Oak, OH

Mount Carmel Health Center (East)

Whitehall, OH

Cleveland Clinic (Wooster Family Health and Surgery Center)

Wooster, OH

Genesis HealthCare System

Zanesville, OH

Cancer Centers of Southwest Oklahoma

Lawton, OK

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Mercy Hospital Oklahoma City

Oklahoma City, OK

Oklahoma Cancer Specialists and Research Institute (Tulsa)

Tulsa, OK

Clackamas Radiation Oncology Center

Clackamas, OR

Bay Area Hospital

Coos Bay, OR

Providence Newberg Medical Center

Newberg, OR

Legacy Good Samaritan Hospital and Medical Center

Portland, OR

Providence Portland Medical Center

Portland, OR

Kaiser Permanente Northwest

Portland, OR

Christiana Care Health System-Concord Health Center

Chadds Ford, PA

Geisinger Medical Center (Danville)

Geisinger Med - Danville, PA

Ralph H Johnson VA Medical Center

Charleston, SC

Saint Francis Hospital

Greenville, SC

Saint Francis Hospital Cancer Center

Greenville, SC

Avera Cancer Institute

Sioux Falls, SD

St. Joseph Regional Cancer Center

Bryan, TX

Massey Cancer Center Virginia Commonwealth University (VCU Health)

Richmond, VA

PeaceHealth Medical Group

Bellingham, WA

Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, WA

Harrison Medical Center

Bremerton, WA

Highline Medical Center (Main Campus)

Burien, WA

Swedish Medical Center (Edmonds Campus)

Edmonds, WA

Saint Elizabeth Hospital

Enumclaw, WA

Providence Everett Medical Center

Everett, WA

Saint Francis Hospital

Federal Way, WA

Saint Clare Hospital - CHI Franciscan Health

Lakewood, WA

Saint John Medical Center

Longview, WA

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, WA

Swedish Medical Center (Ballard Campus)

Seattle, WA

Swedish Medical Center (First Hill Campus)

Seattle, WA

CHI Franciscan Health (Northwest Medical Plaza)

Tacoma, WA

Northwest Medical Specialties Hematology/Oncology NWMS Tacoma — Medical Oncology & Infectious Diseases

Tacoma, WA

PeaceHealth Southwest Medical Center

Vancouver, WA

Providence St. Mary Regional Cancer Center

Walla Walla, WA

Duluth Clinic Ashland

Ashland, WI

Aurora Cancer Care (Burlington)

Burlington, WI

Marshfield Clinic Cancer Center (Sacred Heart)

Eau Claire, WI

Aurora Cancer Care (Grafton)

Grafton, WI

Aurora BayCare Medical Center

Green Bay, WI

Aurora Cancer Care (Kenosha South)

Kenosha, WI

Gundersen Lutheran Medical Center

La Crosse, WI

Marshfield Clinic (Marshfield)

Marshfield, WI

Aurora Cancer Care (Milwaukee)

Milwaukee, WI

Aurora Saint Luke's Medical Center

Milwaukee, WI

Aurora Sinai Medical Center

Milwaukee, WI

Marshfield Clinic (Minocqua Center)

Minocqua, WI

Aurora Cancer Care (Racine)

Mount Pleasant, WI

D. N. Greenwald Center

Mukwonago, WI

Cancer Center of Western Wisconsin

New Richmond, WI

Oconomowoc Memorial Hospital-ProHealth Care Inc

Oconomowoc, WI

Aurora Medical Center (Summit)

Oconomowoc, WI

Vince Lombardi Cancer Clinic (Oshkosh)

Oshkosh, WI

Marshfield Clinic (Rice Lake Center)

Rice Lake, WI

Vince Lombardi Cancer Clinic (Sheboygan)

Sheboygan, WI

Marshfield Clinic Cancer Care (Saint Michael's Hospital)

Stevens Point, WI

Vince Lombardi Cancer Clinic (Two Rivers)

Two Rivers, WI

Waukesha Memorial Hospital - ProHealth Care

Waukesha, WI

Aurora Cancer Care (Milwaukee West)

Wauwatosa, WI

Aurora West Allis Medical Center

West Allis, WI

Marshfield Clinic (Weston Center)

Weston, WI

West Virginia University

Morgantown, WV

Billings Clinic (Cody)

Cody, WY

Welch Cancer Center

Sheridan, WY

Not Currently Accepting Patients

The following is a listing of trial locations that are not currently open and accepting patients.

Comprehensive Cancer Center at Desert Regional Medical Center

Palm Springs, CA

Springmill Medical Center

Carmel, IN

Springfield Regional Medical Center

Springfield, OH

Alaska
Alaska Women's Cancer Care

Anchorage, AK

Anchorage Oncology Centre

Anchorage, AK

Katmai Oncology Group

Anchorage, AK

Providence Alaska Medical Center

Anchorage, AK

Arizona
Arkansas
St. Edward Mercy Medical Center

Fort Smith, AR

California
Kaiser Permanente (Antioch Medical Center)

Antioch, CA

Roy and Patricia Disney Family Cancer Center Providence Saint Joseph Medical Center

Burbank, CA

Kaiser Permanente (Fremont Medical Center)

Fremont, CA

Kaiser Permanente (Fresno Medical Center)

Fresno, CA

Rideout Cancer Center (Fremont)

Linda, CA

Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Los Angeles, CA

Kaiser Permanente (Modesto Medical Center)

Modesto, CA

Kaiser Permanente (Oakland Medical Center)

Oakland, CA

Comprehensive Cancer Center at Desert Regional Medical Center

Palm Springs, CA

Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

Kaiser Permanente (Richmond Medical Center)

Richmond, CA

Kaiser Permanente (Roseville Medical Center)

Roseville, CA

Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (San Francisco Medical Center)

San Francisco, CA

Kaiser Permanente (San Jose Medical Center)

San Jose, CA

Kaiser Permanente (San Leandro Medical Center)

San Leandro, CA

Kaiser Permanente (San Rafael Medical Center)

San Rafael, CA

Kaiser Permanente (Santa Clara Medical Center)

Santa Clara, CA

Mission Hope Cancer Center

Santa Maria, CA

Kaiser Permanente (Santa Rosa Medical Center)

Santa Rosa, CA

Kaiser Permanente (South San Francisco Medical Center)

South San Francisco, CA

Kaiser Permanente (Stockton Medical Center)

Stockton, CA

Tahoe Forest Cancer Center

Truckee, CA

Kaiser Permanente (Vacaville Medical Center)

Vacaville, CA

Kaiser Permanente (Vallejo Medical Center)

Vallejo, CA

Kaiser Permanente (Walnut Creek Medical Center)

Walnut Creek, CA

Colorado
Littleton Adventist Hospital

Centennial, CO

Penrose-Saint Francis Healthcare

Colorado Springs, CO

Rocky Mountain Cancer Center Colorado Springs

Colorado Springs, CO

Kaiser Permanente (Franklin)

Denver, CO

Porter Adventist Hospital

Denver, CO

Mercy Medical Center

Durango, CO

Southwest Oncology PC

Durango, CO

Kaiser Permanente (Rock Creek)

Lafayette, CO

Saint Anthony Hospital

Lakewood, CO

Kaiser Permanente Lone Tree Medical Offices

Lone Tree, CO

Longmont United Hospital

Longmont, CO

Rocky Mountain Cancer Center Longmont

Longmont, CO

Parker Adventist Hospital

Parker, CO

Saint Mary Corwin Medical Center

Pueblo, CO

Delaware
Delaware Clinical and Laboratory Physicians PA

Brookside, DE

Helen F. Graham Cancer Center

Brookside, DE

Medical Oncology Hematology Consultants PA

Brookside, DE

Beebe Medical Center

Lewes, DE

Christiana Care Health System (Christiana Hospital)

Newark, DE

Beebe Health Campus

Rehoboth Beach, DE

Nanticoke Memorial Hospital

Seaford, DE

Christiana Care Health System (Wilmington Hospital)

Wilmington, DE

Florida
Advent Health Medical Group Blood & Marrow Transplant

Orlando, FL

Georgia
Northside Hospital

Atlanta, GA

Hawaii
Queen's Medical Center

Honolulu, HI

Straub Clinic and Hospital

Honolulu, HI

University of Hawaii Cancer Center

Honolulu, HI

Kuakini Medical Center

Honolulu, HI

Kaiser Permanente (Moanalua Medical Center)

Honolulu, HI

Kapiolani Medical Center for Women and Children

Honolulu, HI

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, HI

Idaho
St. Luke's Regional Medical Center - Mountain States Tumor Institute (Boise)

Boise, ID

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Kootenai Medical Center

Coeur dAlene, ID

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

Saint Luke's Mountain States Tumor Institute (Meridian)

Meridian, ID

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Kootenai Cancer Center

Post Falls, ID

Kootenai Clinic

Sandpoint, ID

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Illinois
Illinois CancerCare (Bloomington)

Bloomington, IL

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Illinois CancerCare (Canton)

Canton, IL

Memorial Hospital of Carbondale

Carbondale, IL

SIH Cancer Institute

Carterville, IL

Illinois CancerCare (Carthage)

Carthage, IL

Centralia Oncology Clinic

Centralia, IL

Cancer Care Specialists of Central Illinois

Decatur, IL

Decatur Memorial Hospital

Decatur, IL

Illinois CancerCare-Dixon

Dixon, IL

Crossroads Cancer Center

Effingham, IL

Illinois CancerCare (Eureka)

Eureka, IL

Illinois CancerCare (Galesburg)

Galesburg, IL

Western Illinois Cancer Treatment Center

Galesburg, IL

Illinois CancerCare (Kewanee)

Kewanee, IL

Illinois CancerCare (Macomb)

Macomb, IL

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Good Samaritan Regional Health Center

Mount Vernon, IL

Loyola Center for Cancer Care and Research

Orland Park, IL

Illinois CancerCare (Ottawa)

Ottawa, IL

Illinois CancerCare (Pekin)

Pekin, IL

Illinois CancerCare

Peoria, IL

Methodist Medical Center of Illinois

Peoria, IL

Illinois CancerCare (Peru)

Peru, IL

Valley Radiation Oncology

Peru, IL

Illinois CancerCare (Princeton)

Princeton, IL

Southern Illinois University School of Medicine

Springfield, IL

Springfield Clinic

Springfield, IL

Memorial Medical Center

Springfield, IL

Cancer Care Specialists of Illinois (Swansea)

Swansea, IL

Indiana
Springmill Medical Center

Carmel, IN

Iowa
Mary Greeley Medical Center

Ames, IA

McFarland Clinic PC

Ames, IA

McFarland Clinic PC (Boone)

Boone, IA

McFarland Clinic PC (Trinity Cancer Center)

Fort Dodge, IA

McFarland Clinic PC (Jefferson)

Jefferson, IA

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Mercy Medical Center (West Lakes)

West Des Moines, IA

Kansas
Kentucky
Flaget Memorial Hospital

Bardstown, KY

Commonwealth Cancer Center (Corbin)

Corbin, KY

Saint Joseph Hospital

Lexington, KY

Saint Joseph Hospital East

Lexington, KY

Jewish Hospital

Louisville, KY

KentuckyOne Health - James Graham Brown Cancer Center

Louisville, KY

Saints Mary and Elizabeth Hospital

Louisville, KY

Jewish Hospital Medical Center Northeast

Louisville, KY

Jewish Hospital Medical Center South

Shepherdsville, KY

Louisiana
Hematology Oncology Clinic

Baton Rouge, LA

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Maine
Eastern Maine Medical Center

Bangor, ME

Lafayette Family Cancer Center

Brewer, ME

Massachusetts
Boston Medical Center

Boston, MA

Lahey Hospital and Medical Center

Burlington, MA

University of Massachusetts Medical School

Worcester, MA

Michigan
Bronson Battle Creek Cancer Care Center

Battle Creek, MI

Weisberg Cancer Treatment Center

Farmington Hills, MI

Michigan State University (McLaren Regional Medical Center)

Flint, MI

Mercy Health Saint Mary's

Grand Rapids, MI

Spectrum Health

Grand Rapids, MI

Bronson Methodist Hospital

Kalamazoo, MI

West Michigan Cancer Center

Kalamazoo, MI

Borgess Medical Center

Kalamazoo, MI

Mercy Health Mercy Campus

Muskegon Heights, MI

Lakeland Community Hospital

Niles, MI

Spectrum Health Reed City Hospital

Reed City, MI

Lakeland Hospital

Saint Joseph, MI

Marie Yeager Cancer Center

Saint Joseph, MI

Munson Medical Center

Traverse City, MI

Minnesota
Essentia Health Saint Joseph's Medical Center

Brainerd, MN

Fairview Ridges Hospital

Burnsville, MN

Cambridge Medical Center

Cambridge, MN

Mercy Hospital

Coon Rapids, MN

Essentia Health

Deer River, MN

Essentia Health Duluth Clinic CCOP

Duluth, MN

Essentia Health Saint Mary's Medical Center

Duluth, MN

Essentia Health (Miller-Dwan Building)

Duluth, MN

Fairview Southdale Hospital

Edina, MN

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Unity Hospital

Fridley, MN

Essentia Health Hibbing Clinic

Hibbing, MN

Fairview Maple Grove Medical Center

Maple Grove, MN

Minnesota Oncology and Hematology PA (Maplewood)

Maplewood, MN

Saint John's Hospital - Healtheast

Maplewood, MN

Abbott-Northwestern Hospital

Minneapolis, MN

Hennepin County Medical Center

Minneapolis, MN

Health Partners Inc.

Minneapolis, MN

Monticello Cancer Center

Monticello, MN

New Ulm Medical Center

New Ulm, MN

Fairview Northland Medical Center

Princeton, MN

North Memorial Medical Health Center

Robbinsdale, MN

Mayo Clinic (Rochester)

Rochester, MN

Saint Francis Regional Medical Center

Shakopee, MN

Park Nicollet Clinic (Saint Louis Park)

St. Louis Park, MN

Park Nicollet Institute (Louisiana Avenue)

St. Louis Park, MN

Regions Hospital

St. Paul, MN

United Hospital

St. Paul, MN

Lakeview Hospital

Stillwater, MN

Essentia Health Virginia Clinic

Virginia, MN

Ridgeview Medical Center

Waconia, MN

Rice Memorial Hospital

Willmar, MN

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Fairview Lakes Medical Center

Wyoming, MN

Missouri
Verified Alvin J. Siteman Cancer Center Washington University Medical Campus

SparkCures Verified Accurate, up-to-date information. Learn more


Saint Louis Cancer and Breast Institute

Ballwin, MO

Parkland Health Center (Bonne Terre)

Bonne Terre, MO

CoxHealth Cancer Center

Branson, MO

Saint Francis Medical Center (Cape Girardeau)

Cape Girardeau, MO

Southeast Cancer Center

Cape Girardeau, MO

Siteman Cancer Center at West County Hospital

Creve Coeur, MO

Mercy Hospital Saint Louis

Creve Coeur, MO

Capital Region Medical Center (Goldschmidt Cancer Center)

Jefferson City, MO

Freeman Health System

Joplin, MO

Phelps County Regional Medical Center

Rolla, MO

Saint John's Clinic-Rolla-Cancer and Hematology

Rolla, MO

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, MO

Mercy Hospital Springfield

Springfield, MO

CoxHealth South Hospital

Springfield, MO

St. Joseph Oncology

St. Joseph, MO

Heartland Regional Medical Center

St. Joseph, MO

Saint Louis Cancer and Breast Institute (South City)

St. Louis, MO

Mercy Hospital South

St. Louis, MO

Siteman Cancer Center South County

St. Louis, MO

Missouri Baptist Medical Cancer Center

St. Louis, MO

Missouri Baptist Sullivan Hospital

Sullivan, MO

Missouri Baptist Outpatient Center (Sunset Hills)

Sunset Hills, MO

Mercy Hospital Washington

Washington, MO

Montana
Community Hospital of Anaconda

Anaconda, MT

Bozeman Deaconess Hospital

Bozeman, MT

Benefis Healthcare (Sletten Cancer Institute)

Great Falls, MT

Great Falls Clinic

Great Falls, MT

Kalispell Regional Medical Center

Kalispell, MT

Saint Patrick Hospital - Community Hospital

Missoula, MT

Community Medical Hospital

Missoula, MT

Nebraska
CHI Health Saint Francis Medical Center

Grand Island, NE

CHI Health Good Samaritan Hospital

Kearney, NE

Saint Elizabeth Regional Medical Center

Lincoln, NE

Methodist Hospital Nebraska Methodist Health System

Omaha, NE

CHI Health Creighton University Medical Center

Omaha, NE

CHI Health Midlands

Papillion, NE

New Jersey
Valley Medical Group

Paramus, NJ

Valley Health System The Daniel and Gloria Blumenthal Cancer

Paramus, NJ

New Mexico
University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

New York
NewYork-Presbyterian/ Weill Cornell Medical Center

New York, NY

Rochester General Hospital

Rochester, NY

University of Rochester Medical Center James P. Wilmot Cancer Center

Rochester, NY

North Carolina
Verified UNC Lineberger Comprehensive Cancer Center University of North Carolina
Verified Wake Forest Baptist Comprehensive Cancer Center Wake Forest School of Medicine

SparkCures Verified Accurate, up-to-date information. Learn more


Southeastern Medical Oncology Center (Clinton)

Clinton, NC

Southeastern Medical Oncology Center (Goldsboro)

Goldsboro, NC

Southeastern Medical Oncology Center (Jacksonville)

Jacksonville, NC

FirstHealth of the Carolinas (Moore Regional Hosiptal)

Pinehurst, NC

First Health Outpatient Cancer Center

Pinehurst, NC

North Dakota
Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

Ohio
Strecker Cancer Center (Belpre)

Belpre, OH

Bethesda North Hospital

Blue Ash, OH

Adena Regional Medical Center

Chillicothe, OH

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Case Western Reserve University

Cleveland, OH

Cleveland Clinic (Fairview Hospital)

Cleveland, OH

Mount Carmel Health Center West

Columbus, OH

Columbus Oncology and Hematology Associates Inc

Columbus, OH

Riverside Methodist Hospital

Columbus, OH

Grant Medical Center

Columbus, OH

The Mark H. Zangmeister Center

Columbus, OH

Doctors Hospital

Columbus, OH

Dayton Physicians (Miami Valley Hospital South)

Dayton, OH

Miami Valley Hospital

Dayton, OH

Miami Valley Hospital (South)

Dayton, OH

Oncology Hematology Care Inc. (Kenwood)

Deer Park, OH

Delaware Health Center (Grady Cancer Center)

Delaware, OH

Grady Memorial Hospital

Delaware, OH

Blanchard Valley Hospital

Findlay, OH

TriHealth Cancer Institute (Anderson)

Forestville, OH

Atrium Medical Center (Middletown Regional Hospital)

Franklin, OH

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Dayton Physicians (Wilson Memorial Hospital)

Greenville, OH

Wayne Hospital

Greenville, OH

Kettering Medical Center

Kettering, OH

Fairfield Medical Center

Lancaster, OH

Cleveland Clinic (Mansfield)

Mansfield, OH

Marietta Memorial Hospital

Marietta, OH

OhioHealth Marion General Hospital

Marion, OH

Cleveland Clinic (Hillcrest Hospital)

Mayfield Heights, OH

Knox Community Hospital

Mount Vernon, OH

Licking Memorial Hospital

Newark, OH

Newark Radiation Oncology

Newark, OH

Southern Ohio Medical Center

Portsmouth, OH

Cleveland Clinic (North Coast Cancer Care)

Sandusky, OH

Springfield Regional Medical Center

Springfield, OH

Cleveland Clinic (Strongsville Family Health and Surgery Center)

Strongsville, OH

Dayton Physicians (Upper Valley Medical Center)

Troy, OH

Upper Valley Medical Center

Troy, OH

Saint Ann's Hospital

Westerville, OH

TriHealth Cancer Institute (Westside)

White Oak, OH