S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

DRAMMATIC

Overview

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Step 3) to either continue or discontinue the assigned treatment. Patients are treated for up to 7 years from Step 2 reg and followed for up to 15 years.

SparkCures ID 1019
Trial Phase Phase 3
Enrollment 1100 Patients
Treatments
Tags
Trial Sponsors
  • Southwest Oncology Group
Trial Collaborators
  • National Cancer Institute (NCI)
  • Janssen Research & Development
  • Adaptive Biotechnologies
NCT Identifier

NCT04071457

ACCEPTING

This trial is currently open and accepting patients.

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Registration Step 1 Except where otherwise indicated below that test is required in a shorter timeframe, all tests for establishing baseline disease status must be completed within 60 days prior to registration. All test results must be documented on the Baseline Tumor Assessment Form for Multiple Myeloma and the Onstudy Form.

Inclusion Criteria

  • Patients must have had a confirmed diagnosis of symptomatic multiple myeloma (See Section 4.1) that required systemic induction therapy prior to autologous stem cell transplantation (ASCT).
  • Patients with disease measurable by serum light chain assay alone are eligible (defined as >/= 100 mg/L on involved light chain).
  • Patients must be registered to Step 1 prior to registration to Step 2. Registration to Step 1 may take place prior to or after autologous stem cell transplant (ASCT), but after completion of induction therapy.
  • Patients must have initiated induction therapy within 12 months prior to registration Step 1 and have received at least two cycles of induction therapy.
  • Patients must be willing and able to take DVT prophylaxis (aspirin, low molecular weight heparin, warfarin, or equivalent oral anticoagulation).
  • Patients must be >/= 18 and
  • Patients must have history and physical exam within 28 days prior to registration.
  • Patients must have Zubrod Performance Status
  • Patients must have evidence of adequate renal function, as defined by (1) creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or (2) serum creatinine < 2.5 mg/dL. Values must be obtained within 28 days prior to registration.
  • Patients must have adequate hepatic function defined by the following within 42 days prior to registration:
    • Total bilirubin
    • AST and ALT
  • Patients must meet one of the following criteria:
    • Be acceptable for transplant per institutional guidelines and the criteria evidencing this must be documented on the S1803 Onstudy Form. (See Appendix 18.3 for standard transplant eligibility guidelines. Note that these are guidelines and not required criteria.) OR
    • Have completed autologous stem cell transplant within 180 days prior to registration (see also Section 5.2a).
  • Patient's with human immunodeficiency virus (HIV) are eligible providing they are on effective antiretroviral therapy and have undetectable viral load at their most previous viral load test and within 6 months prior to registration.
  • Patients must be able to take and swallow oral medication (capsules) whole. Patients may not have any known impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drug (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).
  • For patients who have not yet received transplant: Patients must be willing and able to return to the transplant center for their assigned treatment after randomization. Note that patients need not have a direct relationship with the transplant center in order to register.
  • Patients must submit specimens for MRD as outlined in Section 15.1. See Section 15.1 for further information, including specimen submission timepoints. Note that patients are not ineligible based solely on archival specimens being unavailable.
  • Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted as outlined in Section 15.2.
  • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
  • As a part of the OPEN registration process (see Section 13.3 for OPEN access instructions) the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

Exclusion Criteria

  • Patients with smoldering myeloma are not eligible. Patients with purely non-secretory MM as measured by electrophoresis and immunofixation and the absence of Bence Jones proteins in the urine are not eligible. Patients must have measurable M protein in the serum (defined as >/= 0.5g/dL) or urine (defined as >/= 200 mg/24h). Patients with plasma cell leukemia are not eligible.
  • Patients must not have any organ involvement by amyloidosis or evidence of amyloidosis related organ dysfunction.
  • Patients must not have progressive disease at any time prior to registration.
  • Patients must not be refractory to either lenalidomide or daratumumab/rHuPH20.
  • Patients must not be intolerant to either lenalidomide or daratumumab/rHuPH20.
  • Patients must not have received any investigational agents within 14 days prior to registration.
  • Patients must not have chronic obstructive pulmonary disease with a forced expiratory volume in 1 second (FEV1) < 50% of predicted normal. FEV1 is required for patients suspected of having chronic obstructive pulmonary disease and are not eligible if FEV1 is < 50% of predicted normal.
  • Patients must not have moderate or severe persistent asthma within the past 2 years and must not have currently uncontrolled asthma of any classification.
  • Patients must not have had prior autograft or allograft, or prior organ transplant requiring immunosuppressive therapy.
  • Patients must not have known allergy to any of the study drugs.
  • Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progression or no clinical improvement) at time of enrollment are not eligible.
  • Patients must not have known central nervous system (CNS) involvement with multiple myeloma, defined as CSF positivity for plasma cells at any time or a parenchymal CNS plasmacytoma at time of enrollment. Lumbar puncture is not required.
  • Patients must not be seropositive for hepatitis C (except in the setting of sustained virologic response, defined as undetectable viral load at least 12 weeks after completion of antiviral therapy). HCV testing is only required if clinically indicated or if the patient has a history of HCV.
  • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years.
  • Patients must not have any uncontrolled intercurrent illness including (not limited to): Symptomatic CHF (NYHA III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration, Unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI CTCAE v5.0 Grade >/= 2), intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>/= Grade 3), or known psychiatric illness that would limit study compliance.

Registration Step 2 - First Randomization (Post-ASCT, Pre-Maintenance)

Inclusion Criteria:

  • Patients must have completed ASCT within 180 days prior to registering to Step 2.
  • Patients must have one of the following performed within 60 days prior to registration for disease assessment: diagnostic quality skeletal survey, whole body CT scan, MRI, or PET.
  • Patients must have Zubrod Performance Status
  • Patients must have adequate bone marrow function as evidenced by platelets >/= 75,000/mm3 and ANC >/= 1,000/mm3 within 28 days prior to first randomization:
  • Patients must have adequate hepatic function defined by the following within 28 days prior to first randomization:
  • Total bilirubin
  • Patients must have evidence of adequate renal function, as defined by creatinine clearance (CrCl) >/= 30 mL/min., as measured by a 24-hour urine collection, or estimated by the Cockcroft and Gault formula, or have a serum creatinine < 2.5 mg/dL within 28 days prior to first randomization.
  • All ASCT-related toxicities must have recovered to
  • Mucositis and gastrointestinal symptoms must have resolved to
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to registration.
  • FCBP must agree to have a second pregnancy test within 24 hours prior to starting Cycle 1. Further, FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide. FCBP must also agree to ongoing pregnancy testing and must agree to not become pregnant for at least 3 months after the last dose of study treatment.
  • Men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy, during the study treatment and for 3 months after the last dose of study treatment.
  • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

Exclusion Criteria:

  • Patients must not have received any other maintenance therapy post-ASCT and prior to Step 2 registration.
  • Patients must not have had progressive disease between induction and registration to Registration Step 2. (See Section 10.1b).

Registration Step 3 - Second Randomization (Post 24 Months Maintenance)

Inclusion Criteria:

  • Patients must have completed 24 cycles of protocol maintenance with either lenalidomide or lenalidomide + daratumumab/rHuPH20.
  • Patients must have 24-month MRD by NGS test results available and must be MRD negative. Patients whose PCR results are indeterminable will be considered to have positive results.
  • Patients must be in very good partial remission (VGPR) or better by IMWG response criteria (see Section 10.1b).
🤔 Am I Eligible?

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US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

Verified Holden Comprehensive Cancer Center University of Iowa Hospitals and Clinics
Holden Comprehensive Cancer Center University of Iowa Hospitals and Clinics

Iowa City, IA

Verified Alvin J. Siteman Cancer Center Washington University Medical Campus
Alvin J. Siteman Cancer Center Washington University Medical Campus

St. Louis, MO

Verified UNC Lineberger Comprehensive Cancer Center University of North Carolina
UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Verified Wake Forest Baptist Comprehensive Cancer Center Wake Forest School of Medicine
Wake Forest Baptist Comprehensive Cancer Center Wake Forest School of Medicine

Winston-Salem, NC

Verified UW Carbone Cancer Center University of Wisconsin Health
UW Carbone Cancer Center University of Wisconsin Health

Madison, WI

Verified Medical College of Wisconsin Froedtert Hospital
Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

SparkCures Verified Accurate, up-to-date information. Learn more

Alaska Women's Cancer Care

Anchorage, AK

Anchorage Oncology Centre

Anchorage, AK

Katmai Oncology Group

Anchorage, AK

Providence Alaska Medical Center

Anchorage, AK

Mercy Hospital Fort Smith

Fort Smith, AR

University of Arkansas for Medical Sciences (UAMS)

Little Rock, AR

University of Arizona Cancer Center - North Campus

Tucson, AZ

Banner - University Medical Center Tucson Banner Health

Tucson, AZ

Kaiser Permanente (Antioch Medical Center)

Antioch, CA

Alta Bates Summit Medical Center - Alta Bates Campus

Berkeley, CA

Roy and Patricia Disney Family Cancer Center Providence Saint Joseph Medical Center

Burbank, CA

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Kaiser Permanente (Dublin)

Dublin, CA

Kaiser Permanente (Fremont Medical Center)

Fremont, CA

Kaiser Permanente (Fresno Medical Center)

Fresno, CA

Rideout Cancer Center (Fremont)

Linda, CA

Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Los Angeles, CA

Kaiser Permanente (Modesto Medical Center)

Modesto, CA

Kaiser Permanente (Oakland Medical Center)

Oakland, CA

Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, CA

Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

Kaiser Permanente (Richmond Medical Center)

Richmond, CA

Kaiser Permanente - Roseville Medical Center

Roseville, CA

Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

University of California Davis Comprehensive Cancer Center

Sacramento, CA

Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (San Francisco Medical Center)

San Francisco, CA

Kaiser Permanente (San Jose Medical Center)

San Jose, CA

Kaiser Permanente - San Leandro Medical Center

San Leandro, CA

Kaiser Permanente (San Rafael Medical Center)

San Rafael, CA

Kaiser Permanente (Santa Clara Medical Center)

Santa Clara, CA

Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

Kaiser Permanente (Santa Rosa Medical Center)

Santa Rosa, CA

Kaiser Permanente (South San Francisco Medical Center)

South San Francisco, CA

Kaiser Permanente (Stockton Medical Center)

Stockton, CA

Tahoe Forest Cancer Center

Truckee, CA

Kaiser Permanente (Vacaville Medical Center)

Vacaville, CA

Kaiser Permanente (Vallejo Medical Center)

Vallejo, CA

Kaiser Permanente (Walnut Creek Medical Center)

Walnut Creek, CA

Littleton Adventist Hospital

Centennial, CO

Centura Penrose Hospital

Colorado Springs, CO

Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

St. Francis Medical Center Catholic Health Initiatives

Colorado Springs, CO

Kaiser Permanente (Franklin)

Denver, CO

Porter Adventist Hospital

Denver, CO

Centura Mercy Hospital

Durango, CO

Centura Southwest Oncology

Durango, CO

Kaiser Permanente - Rock Creek

Lafayette, CO

Centura St. Anthony Hospital

Lakewood, CO

Kaiser Permanente (Lone Tree) Lone Tree Medical Offices

Lone Tree, CO

Centura Longmont United Hospital

Longmont, CO

Rocky Mountain Cancer Centers (Longmont) Longmont

Longmont, CO

Centura Parker Adventist Hospital

Parker, CO

Saint Mary Corwin Medical Center

Pueblo, CO

Beebe Medical Center

Lewes, DE

ChristianaCare Hematology

Newark, DE

ChristianaCare Helen F. Graham Cancer Center Christiana Hospital

Newark, DE

Medical Oncology Hematology Consultants PA in ChristianaCare Helen F. Graham Cancer Center & Research Institute

Newark, DE

Christiana Care Health System (Christiana Hospital)

Newark, DE

Beebe Health Campus

Rehoboth Beach, DE

Nanticoke Memorial Hospital

Seaford, DE

Christiana Care Health System (Wilmington Hospital)

Wilmington, DE

Shands Hospital University of Florida Health

Gainesville, FL

Sylvester Comprehensive Cancer Center University of Miami Health System

Miami, FL

Advent Health Cancer Institute (Orlando)

Orlando, FL

Moffitt Cancer Center Magnolia Campus

Tampa, FL

Northside Hospital (Atlanta)

Atlanta, GA

Grady Memorial Hospital

Atlanta, GA

Pali Momi Medical Center

Aiea, HI

The Cancer Center of Hawaii (Pali Momi)

Aiea, HI

Queen's Medical Center

Honolulu, HI

Hawaii Pacific Health - Straub Medical Center

Honolulu, HI

Kuakini Medical Center

Honolulu, HI

Kaiser Permanente (Moanalua Medical Center)

Honolulu, HI

Kapiolani Medical Center for Women and Children

Honolulu, HI

Queen's Cancer Center - POB Office

Honolulu, HI

Cancer Center at The Queen's Medical Center

Honolulu, HI

Hawaii Cancer Care - Waterfront Plaza

Honolulu, HI

Hawaii Cancer Care - Liliha

Honolulu, HI

Cancer Center of Hawaii - Liliha

Honolulu, HI

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, HI

Mary Greeley Medical Center

Ames, IA

McFarland Clinic PC

Ames, IA

McFarland Clinic PC (Boone)

Boone, IA

Broadlawns Medical Center

Des Moines, IA

Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

MercyOne Des Moines Medical Center

Des Moines, IA

Iowa Lutheran Hospital

Des Moines, IA

McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

UnityPoint Health - Trinity Regional Medical Center

Fort Dodge, IA

McFarland Clinic PC (Jefferson)

Jefferson, IA

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

MercyOne West Des Moines Medical Center

West Des Moines, IA

UnityPoint Health - Methodist West Hospital

West Des Moines, IA

St. Luke's Cancer Institute - Boise

Boise, ID

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

St. Luke's Cancer Institute (Meridian)

Meridian, ID

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Kootenai Cancer Center

Post Falls, ID

Kootenai Clinic

Sandpoint, ID

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Illinois CancerCare (Bloomington)

Bloomington, IL

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Illinois CancerCare (Canton)

Canton, IL

Memorial Hospital of Carbondale

Carbondale, IL

SIH Cancer Institute

Carterville, IL

Illinois CancerCare (Carthage)

Carthage, IL

Centralia Oncology Clinic

Centralia, IL

Cancer Care Specialists of IL - Cancer Care Center of Decatur

Decatur, IL

Memorial Health - Decatur Memorial Hospital Memorial Health

Decatur, IL

Illinois CancerCare-Dixon

Dixon, IL

Cancer Care Specialists (Crossroads Cancer Center)

Effingham, IL

Illinois CancerCare (Eureka)

Eureka, IL

Illinois CancerCare (Galesburg)

Galesburg, IL

Western Illinois Cancer Treatment Center

Galesburg, IL

Illinois CancerCare (Kewanee)

Kewanee, IL

Illinois CancerCare (Macomb)

Macomb, IL

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Good Samaritan Regional Health Center

Mount Vernon, IL

Illinois CancerCare - Fox River Cancer Center

Ottawa, IL

Illinois CancerCare - Pekin

Pekin, IL

Illinois CancerCare - Peoria

Peoria, IL

Methodist Medical Center of Illinois

Peoria, IL

Illinois CancerCare - Peru In Valley Regional Cancer Center

Peru, IL

US Oncology - Valley Regional Cancer Center

Peru, IL

Illinois CancerCare - Princeton

Princeton, IL

Southern Illinois University School of Medicine - Simmons Cancer Institute

Springfield, IL

Springfield Clinic

Springfield, IL

Memorial Medical Center

Springfield, IL

Cancer Care Specialists of Illinois (Swansea)

Swansea, IL

IU Simon Cancer Center Indiana University

Indianapolis, IN

Central Care Cancer Center (Heartland)

Garden City, KS

Central Care Cancer Center - Great Bend

Great Bend, KS

University of Kansas Cancer Center

Kansas City, KS

Flaget Memorial Hospital

Bardstown, KY

Commonwealth Cancer Center (Corbin)

Corbin, KY

Saint Joseph Hospital

Lexington, KY

Saint Joseph Hospital East

Lexington, KY

UK Markey Cancer Center University of Kentucky

Lexington, KY

U of L Health - Jewish Hospital

Louisville, KY

U of L Health - Brown Cancer Center University of Louisville

Louisville, KY

Saints Mary and Elizabeth Hospital

Louisville, KY

Jewish Hospital Medical Center Northeast

Louisville, KY

Jewish Hospital Medical Center South

Shepherdsville, KY

Hematology Oncology Clinic

Baton Rouge, LA

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Ochsner LSU Health Shreveport Ochsner Louisiana State University

Shreveport, LA

Boston Medical Center

Boston, MA

Lahey Hospital and Medical Center

Burlington, MA

University of Massachusetts Medical School

Worcester, MA

Eastern Maine Medical Center

Bangor, ME

Northern Light Eastern Maine Medical Cancer Care Lafayette Family Cancer Institute

Brewer, ME

University of Michigan Comprehensive Cancer Center

Ann Arbor, MI

Bronson Battle Creek Cancer Care Center

Battle Creek, MI

Barbara Ann Karmanos Cancer Institute Wayne State University

Detroit, MI

Karmanos-Weisberg Cancer Treatment Center

Farmington Hills, MI

McLaren Regional Medical Center (Flint)

Flint, MI

Mercy Health Saint Mary's

Grand Rapids, MI

Spectrum Health

Grand Rapids, MI

Bronson Methodist Hospital

Kalamazoo, MI

West Michigan Cancer Center

Kalamazoo, MI

Borgess Medical Center

Kalamazoo, MI

Mercy Health Mercy Campus

Muskegon, MI

Lakeland Community Hospital

Niles, MI

Spectrum Health Reed City Hospital

Reed City, MI

Spectrum Health Lakeland Medical Center

St. Joseph, MI

Spectrum Health Marie Yeager Cancer Center

St. Joseph, MI

Munson Medical Center

Traverse City, MI

Essentia Health Saint Joseph's Medical Center

Brainerd, MN

M Health Fairview Ridges Hospital

Burnsville, MN

Cambridge Medical Center

Cambridge, MN

Mercy Hospital

Coon Rapids, MN

Essentia Health

Deer River, MN

Essentia Health (Duluth Clinic)

Duluth, MN

Essentia Health Saint Mary's Medical Center

Duluth, MN

Essentia Health (Miller-Dwan Building)

Duluth, MN

Fairview Southdale Hospital

Edina, MN

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Unity Hospital

Fridley, MN

Essentia Health Hibbing Clinic

Hibbing, MN

Fairview Maple Grove Medical Center

Maple Grove, MN

Minnesota Oncology Maplewood Cancer Center

Maplewood, MN

M Health Fairview St. John's Hospital

Maplewood, MN

Abbott-Northwestern Hospital Allina Health

Minneapolis, MN

Hennepin County Medical Center

Minneapolis, MN

Health Partners Inc.

Minneapolis, MN

University of Minnesota - Masonic Cancer Center University of Minnesota

Minneapolis, MN

Monticello Cancer Center

Monticello, MN

New Ulm Medical Center

New Ulm, MN

Fairview Northland Medical Center

Princeton, MN

North Memorial Medical Health Center

Robbinsdale, MN

Mayo Clinic (Rochester)

Rochester, MN

Saint Francis Regional Medical Center

Shakopee, MN

Coborn Cancer Center at Saint Cloud Hospital

St. Cloud, MN

Park Nicollet Specialty Center at Methodist Hospital

St. Louis Park, MN

Park Nicollet Institute (Louisiana Avenue)

St. Louis Park, MN

Regions Hospital

St. Paul, MN

United Hospital

St. Paul, MN

Lakeview Hospital

Stillwater, MN

Essentia Health Virginia Clinic

Virginia, MN

Ridgeview Medical Center

Waconia, MN

Rice Memorial Hospital

Willmar, MN

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Fairview Lakes Medical Center

Wyoming, MN

Saint Louis Cancer and Breast Institute

Ballwin, MO

Central Care Cancer Center

Bolivar, MO

Parkland Health Center (Bonne Terre)

Bonne Terre, MO

CoxHealth Cancer Center

Branson, MO

Saint Francis Medical Center (Cape Girardeau)

Cape Girardeau, MO

Southeast Cancer Center Southeast Health

Cape Girardeau, MO

Siteman Cancer Center at Barnes-Jewish West County Hospital

Creve Coeur, MO

Capital Region Medical Center (Goldschmidt Cancer Center)

Jefferson City, MO

Freeman Cornell-Beshore Cancer Institute

Joplin, MO

Phelps Health Hospital

Rolla, MO

Mercy Clinic Cancer and Hematology (Rolla)

Rolla, MO

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, MO

Mercy Hospital Springfield

Springfield, MO

CoxHealth South Hospital Cox Medical Center South

Springfield, MO

St. Joseph Oncology

St. Joseph, MO

Heartland Regional Medical Center

St. Joseph, MO

Saint Louis Cancer and Breast Institute (South City)

St. Louis, MO

Mercy Hospital South

St. Louis, MO

Siteman Cancer Center (South St. Louis County)

St. Louis, MO

Missouri Baptist Medical Cancer Center

St. Louis, MO

Mercy Hospital St. Louis

St. Louis, MO

Missouri Baptist Sullivan Hospital

Sullivan, MO

Missouri Baptist Outpatient Center (Sunset Hills)

Sunset Hills, MO

Mercy Hospital Washington

Washington, MO

Community Hospital of Anaconda

Anaconda, MT

Billings Clinic Cancer Center

Billings, MT

Bozeman Deaconess Hospital

Bozeman, MT

Benefis Sletten Cancer Institute

Great Falls, MT

Great Falls Clinic Specialty Center

Great Falls, MT

Kalispell Regional Medical Center

Kalispell, MT

Providence St. Patrick Hospital

Missoula, MT

Community Medical Hospital

Missoula, MT

Levine Cancer Institute Atrium Health

Charlotte, NC

Southeastern Medical Oncology Center (Clinton)

Clinton, NC

Southeastern Medical Oncology Center (Goldsboro)

Goldsboro, NC

Southeastern Medical Oncology Center (Jacksonville)

Jacksonville, NC

FirstHealth Moore Regional Hospital

Pinehurst, NC

FirstHealth Outpatient Cancer Center

Pinehurst, NC

Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

CHI Health St. Francis

Grand Island, NE

CHI Health Good Samaritan Hospital

Kearney, NE

CHI Health St. Elizabeth St. Elizabeth Regional Medical Center

Lincoln, NE

Methodist Hospital Nebraska Methodist Health System

Omaha, NE

CHI Health Creighton University Medical Center

Omaha, NE

CHI Health Midlands

Papillion, NE

Cooper University Hospital

Camden, NJ

Valley Health System - Luckow Pavilion

Paramus, NJ

University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

Rochester General Hospital

Rochester, NY

University of Rochester Medical Center James P. Wilmot Cancer Center

Rochester, NY

Stony Brook University Hospital

Stony Brook, NY

Strecker Cancer Center (Belpre)

Belpre, OH

Miami Valley Hospital South

Centerville, OH

Geaugra Hospital

Chardon, OH

Adena Regional Medical Center

Chillicothe, OH

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Oncology Hematology Care Inc. (Kenwood)

Cincinnati, OH

TriHealth Bethesda North Hospital

Cincinnati, OH

Case Western Reserve University

Cleveland, OH

Cleveland Clinic (Fairview Hospital)

Cleveland, OH

Cleveland Clinic Taussig Cancer Institute

Cleveland, OH

University Hospitals Seidman Cancer Center Seidman Cancer Center at UH Case Medical

Cleveland, OH

The Ohio State University Comprehensive Cancer Center The James Cancer Hospital and Solove Research Institute

Columbus, OH

Mount Carmel Health Center West

Columbus, OH

Columbus Oncology and Hematology Associates

Columbus, OH

OhioHealth Riverside Methodist Hospital

Columbus, OH

OhioHealth Grant Medical Center

Columbus, OH

The Mark H. Zangmeister Center

Columbus, OH

Doctors Hospital

Columbus, OH

Dayton Physicians, LLC

Dayton, OH

Miami Valley Hospital

Dayton, OH

OhioHealth Grady Memorial Hospital Cancer Center

Delaware, OH

Blanchard Valley Hospital

Findlay, OH

TriHealth Cancer Institute (Anderson)

Forestville, OH

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Wayne Healthcare

Greenville, OH

Kettering Medical Center

Kettering, OH

Fairfield Medical Center

Lancaster, OH

Saint Rita's Medical Center

Lima, OH

Cleveland Clinic (Mansfield)

Mansfield, OH

Marietta Memorial Hospital

Marietta, OH

OhioHealth Marion General Hospital

Marion, OH

Cleveland Clinic (Hillcrest Hospital)

Mayfield Heights, OH

Premier Health Atrium Medical Center - Middletown

Middletown, OH

Knox Community Hospital

Mount Vernon, OH

Licking Memorial Hospital

Newark, OH

Newark Radiation Oncology

Newark, OH

Southern Ohio Medical Center

Portsmouth, OH

Cleveland Clinic Cancer Center - Kinzel Campus Judith and Richard Kinzel Campus

Sandusky, OH

Dayton Physicians (Wilson Memorial Hospital)

Sidney, OH

Springfield Regional Medical Center

Springfield, OH

Cleveland Clinic (Strongsville Family Health and Surgery Center)

Strongsville, OH

Saint Vincent Mercy Medical Center

Toledo, OH

Dayton Physicians - Upper Valley Medical Center

Troy, OH

Premier Health Upper Valley Medical Center

Troy, OH

Saint Ann's Hospital

Westerville, OH

UH Seidman Cancer Center - St. John Medical Center

Westlake, OH

TriHealth Cancer Institute (Westside)

White Oak, OH

Mount Carmel Health Center (East)

Whitehall, OH

Cleveland Clinic - Wooster Family Health Center

Wooster, OH

Genesis HealthCare System

Zanesville, OH

Cancer Centers of Southwest Oklahoma

Lawton, OK

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Mercy Hospital Oklahoma City

Oklahoma City, OK

Oklahoma Cancer Specialists and Research Institute (Tulsa)

Tulsa, OK

Clackamas Radiation Oncology Center

Clackamas, OR

Bay Area Hospital

Coos Bay, OR

Providence Newberg Medical Center

Newberg, OR

Oregon Health and Science University (OHSU) Knight Cancer Institute

Portland, OR

Providence Portland Medical Center

Portland, OR

Kaiser Permanente Northwest

Portland, OR

Christiana Care Health System-Concord Health Center

Chadds Ford, PA

Geisinger Medical Center - Danville

Danville, PA

Penn State Hershey Medical Center

Hershey, PA

Abramson Cancer Center University of Pennsylvania

Philadelphia, PA

Ralph H Johnson VA Medical Center VA Charleston

Charleston, SC

McLeod Regional Medical Center

Florence, SC

Bon Secours St. Francis Hospital (Downtown)

Greenville, SC

Saint Francis Hospital Cancer Center

Greenville, SC

Avera Cancer Institute - Sioux Falls

Sioux Falls, SD

St. Joseph Regional Cancer Center

Bryan, TX

MD Anderson Cancer Center The University of Texas

Houston, TX

Huntsman Cancer Institute University of Utah

Salt Lake City, UT

Massey Cancer Center Virginia Commonwealth University (VCU Health)

Richmond, VA

PeaceHealth Medical Group

Bellingham, WA

St. Michael - Harrison Medical Center

Bremerton, WA

Highline Medical Center (Main Campus)

Burien, WA

Swedish Medical Center (Edmonds Campus)

Edmonds, WA

Saint Elizabeth Hospital

Enumclaw, WA

Providence Everett Medical Center

Everett, WA

Saint Francis Hospital

Federal Way, WA

Saint Clare Hospital - CHI Franciscan Health

Lakewood, WA

Saint John Medical Center

Longview, WA

Swedish Medical Center (Ballard Campus)

Seattle, WA

Swedish - First Hill Campus

Seattle, WA

Swedish - Cherry Hill Campus Cherry Hill Campus

Seattle, WA

St. Michael Cancer Center Virginia Mason Franciscan Health

Silverdale, WA

Virginia Mason Franciscan Health Research Center (Tacoma) CHI Franciscan

Tacoma, WA

PeaceHealth Southwest Medical Center

Vancouver, WA

Providence St. Mary Regional Cancer Center

Walla Walla, WA

Essentia Health - Ashland Clinic

Ashland, WI

Aurora Cancer Care (Burlington)

Burlington, WI

Aurora Saint Luke's South Shore

Cudahy, WI

Marshfield Medical Center Cancer Center - Eau Claire

Eau Claire, WI

Aurora Cancer Care (Grafton)

Grafton, WI

Aurora BayCare Medical Center

Green Bay, WI

Aurora Cancer Care (Kenosha South)

Kenosha, WI

Gundersen Lutheran Medical Center

La Crosse, WI

Marshfield Medical Center - Medical Offices Building

Marshfield, WI

Aurora Cancer Care (Milwaukee)

Milwaukee, WI

Aurora St. Luke's Medical Center

Milwaukee, WI

Aurora Sinai Medical Center

Milwaukee, WI

Marshfield Clinic (Minocqua Center)

Minocqua, WI

Aurora Cancer Care (Racine)

Mount Pleasant, WI

D. N. Greenwald Center

Mukwonago, WI

Cancer Center of Western Wisconsin

New Richmond, WI

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, WI

Aurora Health - Vince Lombardi Cancer Clinic (Summit)

Oconomowoc, WI

Vince Lombardi Cancer Clinic (Oshkosh)

Oshkosh, WI

Marshfield Clinic (Rice Lake Center)

Rice Lake, WI

Vince Lombardi Cancer Clinic - Sheboygan

Sheboygan, WI

Marshfield Clinic Cancer Care (Saint Michael's Hospital)

Stevens Point, WI

Vince Lombardi Cancer Clinic (Two Rivers)

Two Rivers, WI

ProHealth Waukesha Memorial Hospital

Waukesha, WI

Aurora Cancer Care (Milwaukee West)

Wauwatosa, WI

Aurora West Allis Medical Center

West Allis, WI

Marshfield Medical Center (Weston)

Weston, WI

West Virginia University

Morgantown, WV

Billings Clinic (Cody)

Cody, WY

Welch Cancer Center

Sheridan, WY

Not Currently Accepting Patients

The following is a listing of trial locations that are not currently open and accepting patients.

Springmill Medical Center

Indianapolis, IN

Walter Reed National Military Medical Center

Bethesda, MD

Mercy Health - St. Anne Hospital

Toledo, OH

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, WA

Northwest Medical Specialties (Tacoma) NWMS Tacoma — Medical Oncology & Infectious Diseases

Tacoma, WA

Alaska
Alaska Women's Cancer Care

Anchorage, AK

  • Recruiting
Anchorage Oncology Centre

Anchorage, AK

  • Recruiting
Katmai Oncology Group

Anchorage, AK

  • Recruiting
Providence Alaska Medical Center

Anchorage, AK

  • Recruiting
Arizona
University of Arizona Cancer Center - North Campus

Tucson, AZ

  • Recruiting
Banner - University Medical Center Tucson Banner Health

Tucson, AZ

  • Recruiting
Arkansas
Mercy Hospital Fort Smith

Fort Smith, AR

  • Recruiting
University of Arkansas for Medical Sciences (UAMS)

Little Rock, AR

  • Recruiting
California
Kaiser Permanente (Antioch Medical Center)

Antioch, CA

  • Recruiting
Alta Bates Summit Medical Center - Alta Bates Campus

Berkeley, CA

  • Recruiting
Roy and Patricia Disney Family Cancer Center Providence Saint Joseph Medical Center

Burbank, CA

  • Recruiting
City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

  • Recruiting
Kaiser Permanente (Dublin)

Dublin, CA

  • Recruiting
Kaiser Permanente (Fremont Medical Center)

Fremont, CA

  • Recruiting
Kaiser Permanente (Fresno Medical Center)

Fresno, CA

  • Recruiting
Rideout Cancer Center (Fremont)

Linda, CA

  • Recruiting
Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Los Angeles, CA

  • Recruiting
Kaiser Permanente (Modesto Medical Center)

Modesto, CA

  • Recruiting
Kaiser Permanente (Oakland Medical Center)

Oakland, CA

  • Recruiting
Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, CA

  • Recruiting
Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

  • Recruiting
Kaiser Permanente (Richmond Medical Center)

Richmond, CA

  • Recruiting
Kaiser Permanente - Roseville Medical Center

Roseville, CA

  • Recruiting
Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

  • Recruiting
University of California Davis Comprehensive Cancer Center

Sacramento, CA

  • Recruiting
Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

  • Recruiting
Kaiser Permanente (San Francisco Medical Center)

San Francisco, CA

  • Recruiting
Kaiser Permanente (San Jose Medical Center)

San Jose, CA

  • Recruiting
Kaiser Permanente - San Leandro Medical Center

San Leandro, CA

  • Recruiting
Kaiser Permanente (San Rafael Medical Center)

San Rafael, CA

  • Recruiting
Kaiser Permanente (Santa Clara Medical Center)

Santa Clara, CA

  • Recruiting
Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

  • Recruiting
Kaiser Permanente (Santa Rosa Medical Center)

Santa Rosa, CA

  • Recruiting
Kaiser Permanente (South San Francisco Medical Center)

South San Francisco, CA

  • Recruiting
Kaiser Permanente (Stockton Medical Center)

Stockton, CA

  • Recruiting
Tahoe Forest Cancer Center

Truckee, CA

  • Recruiting
Kaiser Permanente (Vacaville Medical Center)

Vacaville, CA

  • Recruiting
Kaiser Permanente (Vallejo Medical Center)

Vallejo, CA

  • Recruiting
Kaiser Permanente (Walnut Creek Medical Center)

Walnut Creek, CA

  • Recruiting
Colorado
Littleton Adventist Hospital

Centennial, CO

  • Recruiting
Centura Penrose Hospital

Colorado Springs, CO

  • Recruiting
Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

  • Recruiting
St. Francis Medical Center Catholic Health Initiatives

Colorado Springs, CO

  • Recruiting
Kaiser Permanente (Franklin)

Denver, CO

  • Recruiting
Porter Adventist Hospital

Denver, CO

  • Recruiting
Centura Mercy Hospital

Durango, CO

  • Recruiting
Centura Southwest Oncology

Durango, CO

  • Recruiting
Kaiser Permanente - Rock Creek

Lafayette, CO

  • Recruiting
Centura St. Anthony Hospital

Lakewood, CO

  • Recruiting
Kaiser Permanente (Lone Tree) Lone Tree Medical Offices

Lone Tree, CO

  • Recruiting
Centura Longmont United Hospital

Longmont, CO

  • Recruiting
Rocky Mountain Cancer Centers (Longmont) Longmont

Longmont, CO

  • Recruiting
Centura Parker Adventist Hospital

Parker, CO

  • Recruiting
Saint Mary Corwin Medical Center

Pueblo, CO

  • Recruiting
Delaware
Beebe Medical Center

Lewes, DE

  • Recruiting
ChristianaCare Hematology

Newark, DE

  • Recruiting
ChristianaCare Helen F. Graham Cancer Center Christiana Hospital

Newark, DE

  • Recruiting
Medical Oncology Hematology Consultants PA in ChristianaCare Helen F. Graham Cancer Center & Research Institute

Newark, DE

  • Recruiting
Christiana Care Health System (Christiana Hospital)

Newark, DE

  • Recruiting
Beebe Health Campus

Rehoboth Beach, DE

  • Recruiting
Nanticoke Memorial Hospital

Seaford, DE

  • Recruiting
Christiana Care Health System (Wilmington Hospital)

Wilmington, DE

  • Recruiting
Florida
Shands Hospital University of Florida Health

Gainesville, FL

  • Recruiting
Sylvester Comprehensive Cancer Center University of Miami Health System

Miami, FL

  • Recruiting
Advent Health Cancer Institute (Orlando)

Orlando, FL

  • Recruiting
Moffitt Cancer Center Magnolia Campus

Tampa, FL

  • Recruiting
Georgia
Northside Hospital (Atlanta)

Atlanta, GA

  • Recruiting
Grady Memorial Hospital

Atlanta, GA

  • Recruiting
Hawaii
Pali Momi Medical Center

Aiea, HI

  • Recruiting
The Cancer Center of Hawaii (Pali Momi)

Aiea, HI

  • Recruiting
Queen's Medical Center

Honolulu, HI

  • Recruiting
Hawaii Pacific Health - Straub Medical Center

Honolulu, HI

  • Recruiting
Kuakini Medical Center

Honolulu, HI

  • Recruiting
Kaiser Permanente (Moanalua Medical Center)

Honolulu, HI

  • Recruiting
Kapiolani Medical Center for Women and Children

Honolulu, HI

  • Recruiting
Queen's Cancer Center - POB Office

Honolulu, HI

  • Recruiting
Cancer Center at The Queen's Medical Center

Honolulu, HI

  • Recruiting
Hawaii Cancer Care - Waterfront Plaza

Honolulu, HI

  • Recruiting
Hawaii Cancer Care - Liliha

Honolulu, HI

  • Recruiting
Cancer Center of Hawaii - Liliha

Honolulu, HI

  • Recruiting
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, HI

  • Recruiting
Idaho
St. Luke's Cancer Institute - Boise

Boise, ID

  • Recruiting
Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

  • Recruiting
Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

  • Recruiting
Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

  • Recruiting
St. Luke's Cancer Institute (Meridian)

Meridian, ID

  • Recruiting
Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

  • Recruiting
Kootenai Cancer Center

Post Falls, ID

  • Recruiting
Kootenai Clinic

Sandpoint, ID

  • Recruiting
Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

  • Recruiting
Illinois
Illinois CancerCare (Bloomington)

Bloomington, IL

  • Recruiting
Loyola Center for Health at Burr Ridge

Burr Ridge, IL

  • Recruiting
Illinois CancerCare (Canton)

Canton, IL

  • Recruiting
Memorial Hospital of Carbondale

Carbondale, IL

  • Recruiting
SIH Cancer Institute

Carterville, IL

  • Recruiting
Illinois CancerCare (Carthage)

Carthage, IL

  • Recruiting
Centralia Oncology Clinic

Centralia, IL

  • Recruiting
Cancer Care Specialists of IL - Cancer Care Center of Decatur

Decatur, IL

  • Recruiting
Memorial Health - Decatur Memorial Hospital Memorial Health

Decatur, IL

  • Recruiting
Illinois CancerCare-Dixon

Dixon, IL

  • Recruiting
Cancer Care Specialists (Crossroads Cancer Center)

Effingham, IL

  • Recruiting
Illinois CancerCare (Eureka)

Eureka, IL

  • Recruiting
Illinois CancerCare (Galesburg)

Galesburg, IL

  • Recruiting
Western Illinois Cancer Treatment Center

Galesburg, IL

  • Recruiting
Illinois CancerCare (Kewanee)

Kewanee, IL

  • Recruiting
Illinois CancerCare (Macomb)

Macomb, IL

  • Recruiting
Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

  • Recruiting
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

  • Recruiting
Good Samaritan Regional Health Center

Mount Vernon, IL

  • Recruiting
Illinois CancerCare - Fox River Cancer Center

Ottawa, IL

  • Recruiting
Illinois CancerCare - Pekin

Pekin, IL

  • Recruiting
Illinois CancerCare - Peoria

Peoria, IL

  • Recruiting
Methodist Medical Center of Illinois

Peoria, IL

  • Recruiting
Illinois CancerCare - Peru In Valley Regional Cancer Center

Peru, IL

  • Recruiting
US Oncology - Valley Regional Cancer Center

Peru, IL

  • Recruiting
Illinois CancerCare - Princeton

Princeton, IL

  • Recruiting
Southern Illinois University School of Medicine - Simmons Cancer Institute

Springfield, IL

  • Recruiting
Springfield Clinic

Springfield, IL

  • Recruiting
Memorial Medical Center

Springfield, IL

  • Recruiting
Cancer Care Specialists of Illinois (Swansea)

Swansea, IL

  • Recruiting
Indiana
IU Simon Cancer Center Indiana University

Indianapolis, IN

  • Recruiting
Springmill Medical Center

Indianapolis, IN

  • Suspended
Iowa
Verified Holden Comprehensive Cancer Center University of Iowa Hospitals and Clinics
Holden Comprehensive Cancer Center University of Iowa Hospitals and Clinics

Iowa City, IA

  • Recruiting

SparkCures Verified Accurate, up-to-date information. Learn more

Mary Greeley Medical Center

Ames, IA

  • Recruiting
McFarland Clinic PC

Ames, IA

  • Recruiting
McFarland Clinic PC (Boone)

Boone, IA

  • Recruiting
Broadlawns Medical Center

Des Moines, IA

  • Recruiting
Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

  • Recruiting
MercyOne Des Moines Medical Center

Des Moines, IA

  • Recruiting
Iowa Lutheran Hospital

Des Moines, IA

  • Recruiting
McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

  • Recruiting
UnityPoint Health - Trinity Regional Medical Center

Fort Dodge, IA

  • Recruiting
McFarland Clinic PC (Jefferson)

Jefferson, IA

  • Recruiting
McFarland Clinic PC (Marshalltown)

Marshalltown, IA

  • Recruiting
MercyOne West Des Moines Medical Center

West Des Moines, IA

  • Recruiting
UnityPoint Health - Methodist West Hospital

West Des Moines, IA

  • Recruiting
Kansas
Central Care Cancer Center (Heartland)

Garden City, KS

  • Recruiting
Central Care Cancer Center - Great Bend

Great Bend, KS

  • Recruiting
University of Kansas Cancer Center

Kansas City, KS

  • Recruiting
Kentucky
Flaget Memorial Hospital

Bardstown, KY

  • Recruiting