A Phase 2 Study Comparing Daratumumab in Combination with Carfilzomib and Dexamethasone compared with Carfilzomib and Dexamethasone in Participants with Multiple Myeloma Who Have Been Previously Treated with Daratumumab LYNX

What's the purpose of this trial?

The purpose of this clinical trial is to determine the safety and efficacy when an investigational medicine is given for a second time to participants with multiple myeloma. This study will also compare the safety and efficacy of the investigational medicine combined with carfilzomib and dexamethasone versus carfilzomib and dexamethasone alone.

This trial is currently open and accepting patients.

What will happen during the trial?

This study will enroll approximately 230 participants, and last for up to five years. This trial is divided into two different treatment groups (arms). Patients will be separated into the different arms randomly. Both Arm A and Arm B will receive treatment in 28 day cycles.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • Patients must have a diagnosis of multiple myeloma.
  • Patients must have previously received 1 to 3 lines of therapy.
  • Patients must have demonstrated a partial response or better for 4 months following daratumumab exposure.
  • Patients must not have previously been treated with carfilzomib.
  • Patients must not have previously had an allogeneic stem cell transplant.

Additional Trial Information

Phase 2

Enrollment: 230 patients (estimated)

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Trial Locations

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The Oncology Institute of Hope and Innovation

Tucson, AZ

Open and Accepting


The Oncology Institute of Hope and Innovation - Whittier

Whittier, CA

Open and Accepting


Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting


Baylor Charles A. Sammons Cancer Center Baylor Scott & White Health

Dallas, TX

Open and Accepting
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