Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma

Overview

This randomized phase III trial studies bortezomib, lenalidomide, and dexamethasone to see how well it works compared to carfilzomib, lenalidomide, and dexamethasone in treating patients with newly diagnosed multiple myeloma. Bortezomib and carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving bortezomib or carfilzomib together with lenalidomide and dexamethasone may kill more cancer cells.

SparkCures ID 22
Trial Phase Phase 3
Enrollment 756 Patients
Treatments
Trial Sponsors
  • Eastern Cooperative Oncology Group (ECOG)
Trial Collaborators
  • National Cancer Institute (NCI)
NCT Identifier

NCT01863550

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Inclusion Criteria:

  • STEP I: Patients must be diagnosed with symptomatic standard-risk multiple myeloma (SR-MM) as defined by all of the following:
    • No evidence of t(4;14), t(14;16),t(14;20), or deletion 17p on fluorescent in situ hybridization (FISH)
    • Standard risk gene expression profile (GEP)70 signature (only if GEP has been done and results are available)
    • Serum lactate dehydrogenase (LDH) =< 2 x upper limit of normal (ULN)
    • No more than 20% circulating plasma cells on white blood cell (WBC) differential or 2,000 plasma cells/microliter of peripheral blood
  • STEP I: Patients must have measurable or evaluable disease as defined by having one or more of the following:
    • >= 1g/dL monoclonal protein (M-protein) on serum protein electrophoresis
    • >= 200 mg/24 hrs of monoclonal protein on a 24 hour urine protein electrophoresis
    • Involved free light chain >= 10 mg/dL AND abnormal serum immunoglobulin kappa to lambda free light chain ratio (< 0.26 or > 1.65)
    • Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease)
    • Serum protein electrophoresis (SPEP), urine protein electrophoresis (UPEP), and serum free light chain (FLC) assay, or bone marrow biopsy and or aspirate are required to be performed within 28 days prior to randomization
      • NOTE: UPEP (on a 24-hour collection) is required, no substitute method is acceptable; urine must be followed monthly if the baseline urine M-spike is >= 200 mg/24 hr; please note that if both serum and urine M-components are present, both must be followed in order to evaluate response
      • NOTE: The serum free light chain test is required to be done if the patient does not have measurable disease in the serum or urine; measurable disease in the serum is defined as having a serum M-spike >= 1 g/dL; measurable disease in the urine is defined as having a urine M-spike >= 200mg/24 hr
  • STEP I: Hemoglobin >= 8 g/dL
  • STEP I: Untransfused platelet count >= 75,000 cells/mm^3
  • STEP I: Absolute neutrophil count >= 1000 cells/mm^3
  • STEP I: Calculated creatinine clearance >= 30 mL/min
  • STEP I: Bilirubin =< 1.5 mg/dL
  • STEP I: Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) < 2.5 times the upper limit of normal
  • STEP I: Patients must have received no more than one cycle (4 weeks or less) of prior chemotherapy and no more than 160mg of prior dexamethasone for treatment of symptomatic myeloma; they should not have been exposed to lenalidomide, bortezomib or carfilzomib for treatment of symptomatic myeloma; prior radiation therapy to symptomatic lesions is allowed provided 14 days have elapsed from the completion of radiation therapy
  • STEP I: Prior systemic glucocorticoid use for the treatment of non-malignant disorders is permitted; prior or concurrent topical or localized glucocorticoid therapy to treat non-malignant comorbid disorders is permitted; note: concurrent use after registration on the study should be restricted to the equivalent of prednisone 10 mg per day
  • STEP I: Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last 6 months
  • STEP I: Patients must not have uncontrolled intercurrent illness including uncontrolled hypertension, symptomatic congestive heart failure, unstable angina, uncontrolled cardiac arrhythmia, uncontrolled psychiatric illness or social situation that would limit compliance with the study, or a prior history of Stevens Johnson Syndrome
  • STEP I: Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2 (PS 3 allowed if secondary to pain)
  • STEP I: Patients with monoclonal gammopathy of undetermined significance or asymptomatic multiple myeloma are not eligible
  • STEP I: Patients must not have grade 2 or higher peripheral neuropathy by Common Terminology Criteria for Adverse Events (CTCAE) 4.0
  • STEP I: Patients must not have active, uncontrolled infection
  • STEP I: Patients may have a history of current or previous deep vein thrombosis or pulmonary embolism but must be willing to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation
  • STEP I: Patients should not have New York Heart Association classification III or IV heart failure or myocardial infarction within the previous 6 months
  • STEP I: Patients with a history of prior malignancy are eligible provided they were treated with curative intent and do not require active therapy (currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "insitu" of the cervix or breast are not excluded)
  • STEP I: Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
  • STEP I: Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse, while taking lenalidomide and for 4 weeks after stopping treatment
  • STEP I: The following patients will be excluded:
    • Pregnant women
    • Nursing women
  • STEP I: Human immunodeficiency virus (HIV) infection is not excluded; known HIV positive patients must meet the following criteria:
    • Cluster of differentiation (CD(4 cell count >= 350/mm^3
    • No history of acquired immune deficiency syndrome (AIDS)-related illness
    • Not currently prescribed zidovudine or stavudine
  • STEP I: Patient enrolling to this study must agree to register to the mandatory RevAssist program, and be willing and able to comply with the requirements of RevAssist
  • STEP I: Patients must be willing to provide biological samples as required by the study
  • STEP II: Patients must not have experienced progression on step 1 induction therapy
  • STEP II: Step 2 registration must be within 28 days of completing step 1 therapy
  • STEP II: Patients must not have received any non-protocol therapy outside of the assigned induction therapy
  • STEP II: ECOG performance status 0, 1, or 2 (PS 3 allowed if secondary to pain)
  • STEP II: Any adverse event related to step 1 therapy must have resolved to grade 2 or less
  • STEP II: Hemoglobin >= 8 g/dL
  • STEP II: Platelet count >= 75,000 cells/mm^3
  • STEP II: Absolute neutrophil count >= 1000 cells/mm^3
  • STEP II: Calculated creatinine clearance >= 30 mL/min
  • STEP II: Bilirubin =< 1.5 mg/dL
  • STEP II: SGPT (ALT) and SGOT (AST) < 2.5 times the upper limit of normal
  • STEP II: FCBP must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
  • STEP II: Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse, while taking lenalidomide and for 4 weeks after stopping treatment
  • STEP II: The following patients will be excluded:
    • Pregnant women
    • Nursing women
  • STEP II: Patient enrolling to this study must agree to register to the mandatory RevAssist program and be willing and able to comply with the requirements of RevAssist

US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

Mercy Cancer Center (Hot Springs)

Hot Springs National Park, AR

CHI Health Good Samaritan Hospital

Kearney, NE

Las Vegas Cancer Center (Medical Center)

Spring Valley, NV

Children's Specialty Center of Nevada II

Winchester, NV

HealthCare Partners Medical Group Oncology/Hematology (Maryland Parkway)

Winchester, NV

21st Century Oncology (Vegas Sunrise)

Winchester, NV

21st Century Oncology (Vegas Tenaya)

Las Vegas, NV

University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

VA New Jersey Health Care System

East Orange, NJ

Rutgers Cancer Institute of New Jersey
Rutgers, The State University of New Jersey

New Brunswick, NJ

Newark Beth Israel Medical Center

Newark, NJ

Inspira Medical Center Vineland

Vineland, NJ

Inspira Medical Center Woodbury

Woodbury, NJ

Wentworth-Douglass Hospital

Dover, NH

Hematology and Oncology Consultants PC

Omaha, NE

Heartland Hematology and Oncology (Kearney)

Kearney, NE

Saint Elizabeth Regional Medical Center

Lincoln, NE

Cancer and Blood Specialists (Fort Apache)

Spring Valley, NV

CHI Health Creighton University Medical Center

Omaha, NE

Regional West Medical Center

Scottsbluff, NE

CHI Health Midlands

Papillion, NE

Midwest Cancer Center - Legacy
Nebraska Cancer Specialists

Omaha, NE

Henry Lynch Cancer Center - Bergan
Nebraska Cancer Specialists

Omaha, NE

Missouri Valley Cancer Consortium

Omaha, NE

CHI Health Lakeside Hospital

Omaha, NE

Nebraska Hematology and Oncology

Lincoln, NE

Faith Regional Medical Offices West

Norfolk, NE

CHI Health Immanuel Medical Center

Omaha, NE

Great Plains Regional Medical Center

North Platte, NE

CHI Health Saint Francis Medical Center

Grand Island, NE

Nebraska Cancer Research Center

Lincoln, NE

Southeast Nebraska Cancer Center

Lincoln, NE

Comprehensive Cancer Centers of Nevada

Spring Valley, NV

21st Century Oncology (Fort Apache)

Spring Valley, NV

Sanford Bismarck Medical Center

Bismarck, ND

Radiation Oncology Centers of Nevada Central

Las Vegas, NV

Marietta Memorial Hospital

Marietta, OH

Saint Ann's Hospital

Westerville, OH

Fairfield Medical Center

Lancaster, OH

Saint Rita's Medical Center

Lima, OH

Blanchard Valley Hospital

Findlay, OH

Delaware Radiation Oncology

Delaware, OH

TriHealth Cancer Institute (Anderson)

Forestville, OH

Oncology Hematology Care Inc. (Healthplex)

Fairfield, OH

Wayne Hospital

Greenville, OH

Kettering Medical Center

Kettering, OH

Atrium Medical Center (Middletown Regional Hospital)

Franklin, OH

SUNY Upstate Medical University
State University of New York

Syracuse, NY

Mary Imogene Bassett Hospital

Cooperstown, NY

Comprehensive Cancer Centers of Nevada (Summerlin)

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (Tenaya)

Las Vegas, NV

HealthCare Partners Medical Group Oncology/Hematology (San Martin)

Spring Valley, NV

Summerlin Hospital Medical Center

Las Vegas, NV

Saint Mary's Regional Medical Center

Reno, NV

Comprehensive Cancer Centers of Nevada (Central Valley)

Paradise, NV

Radiation Oncology Centers of Nevada Southeast

Paradise, NV

Cancer Therapy and Integrative Medicine

Paradise, NV

HealthCare Partners Medical Group Oncology/Hematology (Centennial Hills)

Las Vegas, NV

Nevada Cancer Research Foundation CCOP

Las Vegas, NV

Cancer and Blood Specialists (Henderson)

Henderson, NV

Comprehensive Cancer Centers of Nevada (Northwest)

Las Vegas, NV

Comprehensive Cancer Centers of Nevada (Henderson)

Henderson, NV

Comprehensive Cancer Centers of Nevada (Southeast Henderson)

Henderson, NV

21st Century Oncology (Henderson)

Henderson, NV

Las Vegas Cancer Center (Henderson)

Henderson, NV

Cancer and Blood Specialists (Shadow)

Las Vegas, NV

Cancer and Blood Specialists (Tenaya)

Las Vegas, NV

CHI Health Bergan Mercy Medical Center

Omaha, NE

Essentia Health Cancer Center - South University Clinic (Fargo)

Fargo, ND

Licking Memorial Hospital

Newark, OH

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, MN

Capital Region Medical Center (Goldschmidt Cancer Center)

Jefferson City, MO

Freeman Health System

Joplin, MO

Phelps County Regional Medical Center

Rolla, MO

Saint Francis Medical Center (Cape Girardeau)

Cape Girardeau, MO

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, MO

Mercy Hospital Springfield

Springfield, MO

CoxHealth South Hospital

Springfield, MO

Saint Louis Cancer and Breast Institute (South City)

St. Louis, MO

Missouri Baptist Medical Cancer Center

St. Louis, MO

Missouri Baptist Sullivan Hospital

Sullivan, MO

Missouri Baptist Outpatient Center (Sunset Hills)

Sunset Hills, MO

Saint John's Clinic-Rolla-Cancer and Hematology

Rolla, MO

Minnesota Oncology and Hematology PA (Maplewood)

Maplewood, MN

Unity Hospital

Fridley, MN

Fairview Southdale Hospital

Edina, MN

Southeast Cancer Center

Cape Girardeau, MO

Mercy Hospital

Coon Rapids, MN

United Hospital

St. Paul, MN

Lakeview Hospital

Stillwater, MN

Hennepin County Medical Center

Minneapolis, MN

Ridgeview Medical Center

Waconia, MN

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Health Partners Inc.

Minneapolis, MN

Abbott-Northwestern Hospital

Minneapolis, MN

Essentia Health Duluth Clinic CCOP

Duluth, MN

Essentia Health Saint Mary's Medical Center

Duluth, MN

Saint John's Hospital - Healtheast

Maplewood, MN

Sanford Clinic North-Bemidgi

Bemidji, MN

Fairview Ridges Hospital

Burnsville, MN

Essentia Health (Miller-Dwan Building)

Duluth, MN

Essentia Health Saint Joseph's Medical Center

Brainerd, MN

Mercy Hospital Saint Louis

Creve Coeur, MO

CoxHealth Cancer Center

Branson, MO

Sanford Roger Maris Cancer Center

Fargo, ND

FirstHealth of the Carolinas (Moore Regional Hosiptal)

Pinehurst, NC

Sanford Medical Center

Fargo, ND

Sanford Clinic North (Fargo)

Fargo, ND

Asheville Hematology-Oncology Associates

Asheville, NC

Cone Health Cancer Center (Alamance )

Burlington, NC

Southeastern Medical Oncology Center (Clinton)

Clinton, NC

Southeastern Medical Oncology Center (Goldsboro)

Goldsboro, NC

Randolph Cancer Center

Asheboro, NC

Wayne Memorial Hospital

Goldsboro, NC

Cone Health Cancer Center (Greensboro)

Greensboro, NC

Hendersonville Hematology and Oncology at Pardee

Hendersonville, NC

Park Ridge Hospital Breast Health Center

Hendersonville, NC

Cone Health Cancer Center (Mebane)

Mebane, NC

Onslow Memorial Hospital

Jacksonville, NC

Southeastern Medical Oncology Center (Jacksonville)

Jacksonville, NC

Annie Penn Memorial Hospital

Reidsville, NC

Parkland Health Center (Bonne Terre)

Bonne Terre, MO

Benefis Healthcare (Sletten Cancer Institute)

Great Falls, MT

Central Care Cancer Center

Bolivar, MO

Saint Peter's Community Hospital

Helena, MT

Saint Patrick Hospital - Community Hospital

Missoula, MT

Community Medical Hospital

Missoula, MT

Kalispell Regional Medical Center

Kalispell, MT

Great Falls Clinic

Great Falls, MT

Saint James Community Hospital and Cancer Treatment Center

Butte, MT

Iredell Memorial Hospital

Statesville, NC

Bozeman Deaconess Hospital

Bozeman, MT

Saint Vincent Healthcare

Billings, MT

Community Hospital of Anaconda

Anaconda, MT

Margaret R. Pardee Memorial Hospital

Hendersonville, NC

Southeastern Medical Oncology Center (Wilson)

Wilson, NC

Knox Community Hospital

Mount Vernon, OH

Newark Radiation Oncology

Newark, OH

Park Nicollet Clinic (Saint Louis Park)

St. Louis Park, MN

Aurora Medical Center (Summit)

Oconomowoc, WI

Aurora Cancer Care (Milwaukee West)

Wauwatosa, WI

Marshfield Clinic (Wausau Center)

Wausau, WI

Marshfield Clinic (Minocqua Center)

Minocqua, WI

Vince Lombardi Cancer Clinic (Two Rivers)

Two Rivers, WI

Green Bay Oncology
Ministry Door County Medical Center

Sturgeon Bay, WI

Marshfield Clinic Cancer Care (Saint Michael's Hospital)

Stevens Point, WI

Saint Nicholas Hospital

Sheboygan, WI

Aurora Cancer Care (Waukesha)

Waukesha, WI

Marshfield Clinic (Rice Lake Center)

Rice Lake, WI

Marshfield Clinic (James Beck Cancer Center)

Rhinelander, WI

Saint Mary's Hospital

Rhinelander, WI

Vince Lombardi Cancer Clinic (Oshkosh)

Oshkosh, WI

Green Bay Oncology
Medical Office Building

Oconto Falls, WI

Oconomowoc Memorial Hospital-ProHealth Care Inc

Oconomowoc, WI

Cancer Center of Western Wisconsin

New Richmond, WI

Saint Clare's Hospital

Weston, WI

CHI Franciscan Health (Northwest Medical Plaza)

Tacoma, WA

University of Texas Health Science Center

San Antonio, TX

Massey Cancer Center
Virginia Commonwealth University (VCU Health)

Richmond, VA

Hematology Oncology Associates of Fredericksburg Inc

Fredericksburg, VA

UVA Cancer Center
University of Virginia Health System

Charlottesville, VA

Saint Clare Hospital - CHI Franciscan Health

Lakewood, WA

Northwest Medical Specialties Hematology/Oncology
NWMS Tacoma — Medical Oncology & Infectious Diseases

Tacoma, WA

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, WA

D. N. Greenwald Center

Mukwonago, WI

Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, WA

Saint Francis Hospital

Federal Way, WA

Saint Elizabeth Hospital

Enumclaw, WA

Highline Medical Center (Main Campus)

Burien, WA

Harrison Medical Center

Bremerton, WA

Vince Lombardi Cancer Clinic (Sheboygan)

Sheboygan, WI

Aurora West Allis Medical Center

West Allis, WI

Marshfield Clinic (Weston Center)

Weston, WI

University Hospital

San Antonio, TX

UW Cancer Center Johnson Creek

Johnson Creek, WI

Billings Clinic (Cody)

Cody, WY

Big Horn Basin Cancer Center

Cody, WY

Cheyenne Regional Medical Center (West)

Cheyenne, WY

Aurora Saint Luke's Medical Center

Milwaukee, WI

Aurora Advanced Healthcare Inc (Menomonee Falls)

Menomonee Falls, WI

Marshfield Clinic (Marshfield)

Marshfield, WI

Saint Joseph's Hospital

Marshfield, WI

Bay Area Medical Center

Marinette, WI

Vince Lombardi Cancer Clinic (Marinette)

Marinette, WI

Holy Family Memorial Hospital

Manitowoc, WI

Marshfield Clinic (Ladysmith Center)

Ladysmith, WI

Gundersen Lutheran Medical Center

La Crosse, WI

Aurora Cancer Care (Kenosha South)

Kenosha, WI

Mercy Health System

Janesville, WI

Diagnostic and Treatment Center

Weston, WI

Marshfield Clinic (Chippewa Center)

Chippewa Falls, WI

Marshfield Clinic (Wisconsin Rapids)

Wisconsin Rapids, WI

Aurora Cancer Care (Racine)

Mount Pleasant, WI

Aurora Cancer Care (Milwaukee)

Milwaukee, WI

Aurora Sinai Medical Center

Milwaukee, WI

Aurora Cancer Care (Milwaukee South)

Milwaukee, WI

Aurora Cancer Care (Burlington)

Burlington, WI

Marshfield Clinic Cancer Center (Sacred Heart)

Eau Claire, WI

Aurora BayCare Medical Center

Green Bay, WI

Aurora Cancer Care (Southern Lakes)

Elkhorn, WI

Aurora Health Center (Fond du Lac)

Fond Du Lac, WI

Aurora Cancer Care (Grafton)

Grafton, WI

Green Bay Oncology
Saint Vincent Hospital

Green Bay, WI

Saint Mary's Hospital

Green Bay, WI

Green Bay Oncology
Saint Mary's Hospital

Green Bay, WI

UT Health Science Center Cancer Therapy and Research Center

San Antonio, TX

Ben Taub General Hospital

Houston, TX

Southern Ohio Medical Center

Portsmouth, OH

Oncology Hematology Care Inc. (Mercy West)

Cincinnati, OH

Oklahoma Cancer Specialists and Research Institute (Tulsa)

Tulsa, OK

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Miami Valley Hospital (South)

Dayton, OH

Miami Valley Hospital

Dayton, OH

Good Samaritan Hospital (Dayton)

Dayton, OH

Mount Carmel Health Center West

Columbus, OH

The Mark H. Zangmeister Center

Columbus, OH

Grant Medical Center

Columbus, OH

Columbus Oncology and Hematology Associates Inc

Columbus, OH

Riverside Methodist Hospital

Columbus, OH

MetroHealth Medical Center

Cleveland, OH

Samaritan North Health Center

Clayton, OH

Adena Regional Medical Center

Chillicothe, OH

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Oncology Hematology Care (Eden Park)

Cincinnati, OH

WellSpan Health-York Cancer Center

York, PA

Doctors Hospital

Columbus, OH

Springfield Regional Medical Center

Springfield, OH

Flower Hospital

Sylvania, OH

Upper Valley Medical Center

Troy, OH

TriHealth Cancer Institute (Westside)

White Oak, OH

Genesis HealthCare System

Zanesville, OH

Delaware Health Center (Grady Cancer Center)

Delaware, OH

Grady Memorial Hospital

Delaware, OH

Oncology Hematology Care Inc. (Kenwood)

Deer Park, OH

Oncology Hematology Care Inc. (Anderson)

Cincinnati, OH

Strecker Cancer Center (Belpre)

Belpre, OH

Bethesda North Hospital

Blue Ash, OH

Oncology Hematology Care Inc. (Blue Ash)

Blue Ash, OH

Mercy Medical Center

Canton, OH

Aultman Hospital

Canton, OH

Susquehanna Cancer Center

Williamsport, PA

Dan L. Duncan Comprehensive Cancer Center
Baylor College of Medicine

Houston, TX

Prisma Health
Spartanburg

Spartanburg, SC

Hendrick Medical Center

Abilene, TX

Pulmonary Medicine Center of Chattanooga-Hixson

Chattanooga, TN

CHI Memorial Hospital

Chattanooga, TN

Cookeville Regional Medical Center

Cookeville, TN

Meharry Medical College

Nashville, TN

Memorial GYN Plus

Ooltewah, TN

Sanford USD Medical Center (Sioux Falls)

Sioux Falls, SD

Sanford Cancer Center

Sioux Falls, SD

Rapid City Regional Hospital

Rapid City, SD

Prisma Health
Easley

Easley, SC

Saint Francis Hospital

Greenville, SC

Saint Francis Hospital Cancer Center

Greenville, SC

Prisma Health

Greenville, SC

Prisma Health
Faris

Greenville, SC

Geisinger Medical Center (Wilkes-Barre)

Wilkes-Barre, PA

Cherry Tree Cancer Center

Hanover, PA

Geisinger Medical Group

State College, PA

Reading Hospital and Medical Center

Reading, PA

Geisinger Medical Oncology (Pottsville)

Pottsville, PA

Geisinger Health System (Lewistown Hospital)

Lewistown, PA

Geisinger Medical Oncology (Evangelical Community Hospital)

Lewisburg, PA

Adams Cancer Center

Gettysburg, PA

Prisma Health
Greer

Greer, SC

Geisinger Medical Center (Danville)

Geisinger Med - Danville, PA

Ephrata Cancer Center

Ephrata, PA

Christiana Care Health System-Concord Health Center

Chadds Ford, PA

Geisinger Medical Center (Hazleton)

Hazleton, PA

Prisma Health
Eastside

Greenville, SC

Prisma Health
Seneca

Seneca, SC

Rice Memorial Hospital

Willmar, MN

Saint Francis Regional Medical Center

Shakopee, MN

Sutter Pacific Medical Foundation

Santa Rosa, CA

Smilow Cancer Hospital Care Center (Fairfield)

Fairfield, CT

Sacred Heart Medical Oncology Group (Davis Highway)

Ferry Pass, FL

Christiana Gynecologic Oncology LLC

Brookside, DE

Regional Hematology and Oncology PA

Brookside, DE

Helen F. Graham Cancer Center

Brookside, DE

Delaware Clinical and Laboratory Physicians PA

Brookside, DE

Medical Oncology Hematology Consultants PA

Brookside, DE

Christiana Care Health System (Christiana Hospital)

Newark, DE

Beebe Health Campus

Rehoboth Beach, DE

Nanticoke Memorial Hospital

Seaford, DE

Christiana Care Health System (Wilmington Hospital)

Wilmington, DE

Beebe Medical Center

Lewes, DE

The Center for Cancer Care at Griffin Hospital

Derby, CT

Medical Oncology and Hematology Group PC (Guilford)

Guilford, CT

Northside Hospital

Atlanta, GA

Mercy Medical Center

Durango, CO

National Jewish Health (Main Campus)

Denver, CO

SCL Health Saint Joseph Hospital

Denver, CO

Rose Medical Center

Denver, CO

Rocky Mountain Cancer Centers
Denver - Rose

Denver, CO

Colorado Cancer Research Program NCORP

Denver, CO

Southwest Oncology PC

Durango, CO

Smilow Cancer Hospital Care Center (Saint Francis)

Hartford, CT

Porter Adventist Hospital

Denver, CO

Smilow Cancer Hospital Care Center (Orange)

Orange, CT

Smilow Cancer Hospital - The Harold Leever Regional Cancer Center (Waterbury)

Waterbury, CT

Smilow Cancer Hospital Care Center (Trumbull)

Trumbull, CT

Charlotte Hungerford Hospital Center for Cancer Care

Torrington, CT

Yale-New Haven Hospital - North Haven Medical Center

North Haven, CT

Sacred Heart Medical Oncology Group

Pensacola, FL

Northside Hospital

Cumming, GA

Denver Health Medical Center

Denver, CO

Medical Oncology and Hematology Associates (Laurel)

Des Moines, IA

Radiation Oncology of Northern Illinois

Ottawa, IL

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Kootenai Medical Center

Coeur dAlene, ID

Kootenai Cancer Center

Post Falls, ID

Kootenai Clinic

Sandpoint, ID

McFarland Clinic PC

Ames, IA

Mary Greeley Medical Center

Ames, IA

Hematology Oncology Associates of the Quad Cities

Bettendorf, IA

McFarland Clinic PC (Boone)

Boone, IA

Mercy Cancer Center (West Lakes)

Clive, IA

Medical Oncology and Hematology Associates (West Des Moines)

Clive, IA

Greater Regional Medical Center

Creston, IA

Genesis Medical Center (East Campus)

Davenport, IA

Alegent Health Mercy Hospital

Council Bluffs, IA

McFarland Clinic PC (Trinity Cancer Center)

Fort Dodge, IA

Pali Momi Medical Center

Waimalu, HI

OnCare Hawaii Inc (Kuakini)

Honolulu, HI

OnCare Hawaii Inc (Pali Momi)

Waimalu, HI

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, HI

Kuakini Medical Center

Honolulu, HI

University of Hawaii Cancer Center

Honolulu, HI

Queen's Medical Center

Honolulu, HI

Straub Clinic and Hospital

Honolulu, HI

OnCare Hawaii Inc (POB II)

Honolulu, HI

McFarland Clinic PC (Jefferson)

Jefferson, IA

Kaiser Permanente (Moanalua Medical Center)

Honolulu, HI

OnCare Hawaii (Liliha)

Honolulu, HI

Mercy Medical Center (Des Moines)

Des Moines, IA

Mercy Medical Center (West Lakes)

West Des Moines, IA

Siouxland Hematology Oncology Associates

Sioux City, IA

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Comprehensive Cancer Care and Research Institute of Colorado LLC

Englewood, CO

Rocky Mountain Cancer Center
Colorado Springs

Colorado Springs, CO

Pekin Cancer Treatment Center

Pekin, IL

Kaiser Permanente (Walnut Creek Medical Center)

Walnut Creek, CA

Alta Bates Summit Comprehensive Cancer Center (Berkeley)

Berkeley, CA

Rideout Cancer Center (Fremont)

Linda, CA

St. Jude Heritage Medical Group

Fullerton, CA

Kaiser Permanente (Fresno Medical Center)

Fresno, CA

Kaiser Permanente (Fremont Medical Center)

Fremont, CA

Sutter Davis Hospital

Davis, CA

Mills - Peninsula Medical Center

Burlingame, CA

Kaiser Permanente (Roseville Medical Center)

Roseville, CA

Sutter Auburn Faith Hospital

Auburn, CA

Palo Alto Medical Foundation (Santa Cruz)

Live Oak, CA

Sutter General Hospital

Sacramento, CA

Kaiser Permanente (San Rafael Medical Center)

San Rafael, CA

Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (Antioch Medical Center)

Antioch, CA

Kaiser Permanente (Vallejo Medical Center)

Vallejo, CA

Palo Alto Medical Foundation Health Care (Palo Alto)

Palo Alto, CA

Kaiser Permanente (Santa Clara Medical Center)

Santa Clara, CA

Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

California Pacific Medical Center
Pacific Campus

San Francisco, CA

Kaiser Permanente (San Francisco Medical Center)

San Francisco, CA

Kaiser Permanente (San Jose Medical Center)

San Jose, CA

Kaiser Permanente (San Leandro Medical Center)

San Leandro, CA

Palo Alto Medical Foundation (Sunnyvale)

San Pablo, CA

Kaiser Permanente (Santa Rosa Medical Center)

Santa Rosa, CA

Sutter Solano Cancer Center

Vallejo, CA

Kaiser Permanente (South San Francisco Medical Center)

South San Francisco, CA

Kaiser Permanente (Stockton Medical Center)

Stockton, CA

Tahoe Forest Cancer Center

Truckee, CA

Sutter Cancer Centers Radiation Oncology Services (Vacaville)

Vacaville, CA

Kaiser Permanente (Vacaville Medical Center)

Vacaville, CA

Memorial Medical Center

Modesto, CA

Kaiser Permanente (Modesto Medical Center)

Modesto, CA

Penrose-Saint Francis Healthcare

Colorado Springs, CO

McKee Medical Center

Loveland, CO

Littleton Adventist Hospital

Centennial, CO

Rocky Mountain Cancer Center
Boulder

Boulder, CO

Boulder Community Hospital

Boulder, CO

The Medical Center of Aurora

Aurora, CO

Rocky Mountain Cancer Center
Aurora

Aurora, CO

Kaiser Permanente (Franklin)

Denver, CO

Swedish Medical Center

Englewood, CO

Rocky Mountain Cancer Center
Thornton

Thornton, CO

Mountain Blue Cancer Care Center

Golden, CO

National Jewish Health (Western Hematology Oncology)

Golden, CO

SCL Health Lutheran Medical Center

Wheat Ridge, CO

Rocky Mountain Cancer Centers
Pueblo

Pueblo, CO

Saint Mary Corwin Medical Center

Pueblo, CO

Parker Adventist Hospital

Parker, CO

Longmont United Hospital

Longmont, CO

Kaiser Permanente (Richmond Medical Center)

Richmond, CA

North Colorado Medical Center

Greeley, CO

PCR Oncology

Pismo Beach, CA

Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

Kaiser Permanente (Oakland Medical Center)

Oakland, CA

Sutter Cancer Research Consortium

Novato, CA

Palo Alto Medical Foundation (Mountain View)

Mountain View, CA

Rocky Mountain Cancer Centers
Lone Tree - Skyridge

Lone Tree, CO

Rocky Mountain Cancer Centers
Greenwood Village

Greenwood Village, CO

Rocky Mountain Cancer Center
Longmont

Longmont, CO

Kaiser Permanente (Rock Creek)

Lafayette, CO

Saint Anthony Hospital

Lakewood, CO

Rocky Mountain Cancer Centers
Lakewood

Lakewood, CO

Rocky Mountain Cancer Center
Littleton

Littleton, CO

Kaiser Permanente
Lone Tree Medical Offices

Lone Tree, CO

Rocky Mountain Cancer Centers
Parker

Parker, CO

Illinois CancerCare (Pekin)

Pekin, IL

OSF Saint Francis Medical Center

Peoria, IL

North Memorial Medical Health Center

Robbinsdale, MN

Tufts Medical Center Cancer Center

Boston, MA

Hematology Oncology Consultants

Royal Oak, MI

Oakland Colon and Rectal Association

Royal Oak, MI

Michigan Cancer Specialists

Roseville, MI

Saint Joseph Mercy (Oakland)

Pontiac, MI

Henry Ford Medical Center (Columbus)

Novi, MI

Comprehensive Medical Center PLLC

Royal Oak, MI

Eastern Maine Medical Center

Bangor, ME

Lafayette Family Cancer Center

Brewer, ME

York General Hospital

York, ME

Penobscot Bay Medical Center

Rockport, ME

Frederick Memorial Hospital

Frederick, MD

Walter Reed National Military Medical Center

Bethesda, MD

Baystate Medical Center

Springfield, MA

Medical Oncology LLC

Baton Rouge, LA

Oakland Medical Group

Royal Oak, MI

Flaget Memorial Hospital

Bardstown, KY

Jewish Hospital Medical Center Northeast

Louisville, KY

Jewish Hospital

Louisville, KY

Oncology Hematology Care Inc. (Crestview)

Edgewood, KY

Saint Joseph Hospital East

Lexington, KY

Saint Joseph Hospital

Lexington, KY

Commonwealth Cancer Center (Corbin)

Corbin, KY

Louisiana State University Health Sciences Center (Shreveport)

Shreveport, LA

LSU Health Baton Rouge (North Clinic)

Baton Rouge, LA

University Health (Conway)

Monroe, LA

Terrebonne General Medical Center (Mary Bird Perkins Cancer Center)

Houma, LA

Mary Bird Perkins Cancer Center (Covington)

Covington, LA

Baton Rouge General Medical Center

Baton Rouge, LA

Mary Bird Perkins Cancer Center

Baton Rouge, LA

Louisiana Hematology Oncology Associates

Baton Rouge, LA

Cancer Care Associates PC

Royal Oak, MI

Hematology Oncology Consultants PC (Troy)

Troy, MI

Saints Mary and Elizabeth Hospital

Louisville, KY

Oakwood Hospital

Dearborn, MI

New Ulm Medical Center

New Ulm, MN

Regions Hospital

St. Paul, MN

Weisberg Cancer Treatment Center

Farmington Hills, MI

West Michigan Cancer Center

Kalamazoo, MI

Allegiance Health

Jackson, MI

Green Bay Oncology Ltd.

Iron Mountain, MI

Saint John Hospital and Medical Center

Grosse Pointe Woods, MI

William Beaumont Hospital (Grosse Point)

Grosse Pointe Park, MI

Genesys Hurley Cancer Institute

Flint, MI

Hurley Medical Center

Flint, MI

Botsford General Hospital

Farmington Hills, MI

Henry Ford Medical Center (Fairlane)

Dearborn, MI

Henry Ford Hospital

Detroit, MI

Sparrow Hospital

Lansing, MI

Beaumont Cancer Center

Royal Oak, MI

Saint John Macomb-Oakland Hospital

Warren, MI

Saint Mary's of Michigan

Saginaw, MI

Providence Hospital

Southfield, MI

Premier Hematology Oncology Care

Sterling Heights, MI

Josephine Ford Cancer Institute (Downriver)

Trenton, MI

Michigan Institute of Urology (Town Center)

Troy, MI

William Beaumont Hospital (Troy)

Troy, MI

Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

Huron Valley-Sinai Hospital

Commerce Charter Township, MI

Assarian Cancer Center

Novi, MI

Community Cancer Center of Monroe

Monroe, MI

Saint Mary Mercy Hospital

Livonia, MI

Green Bay Oncology
Saint Francis Hospital

Escanaba, MI

Saint Joseph Mercy Hospital

Ann Arbor, MI

Henry Ford Macomb Hospital

Clinton Township, MI

Jewish Hospital Medical Center South

Shepherdsville, KY

Cancer Center of Kansas (Liberal)

Liberal, KS

Methodist Medical Center of Illinois

Peoria, IL

Illinois CancerCare (Ottawa)

Ottawa, IL

Cancer Care Center of Decatur

Decatur, IL

Decatur Memorial Hospital

Decatur, IL

Weiss Memorial Hospital

Chicago, IL

Rush - Copley Medical Center

Aurora, IL

Centralia Oncology Clinic

Centralia, IL

Illinois CancerCare (Carthage)

Carthage, IL

Memorial Hospital of Carbondale

Carbondale, IL

Illinois CancerCare (Canton)

Canton, IL

Illinois CancerCare (Bloomington)

Bloomington, IL

Saint Joseph Medical Center (Bloomington)

Bloomington, IL

Carle Foundation Hospital (Mattoon)

Mattoon, IL

Carle Foundation Hospital (Vermilion)

Danville, IL

Loyola University Medical Center
Cardinal Bernardin Cancer Center

Maywood, IL

Mount Sinai Hospital Medical Center

Chicago, IL

Good Samaritan Regional Health Center

Mount Vernon, IL

Carle Foundation Hospital (Effingham)

Effingham, IL

SwedishAmerican Regional Cancer Center/ACT

Rockford, IL

Illinois CancerCare

Peoria, IL

OSF Saint Francis Medical Center

Peoria, IL

Illinois CancerCare (Peru)

Peru, IL

Valley Radiation Oncology

Peru, IL

Illinois CancerCare (Princeton)

Princeton, IL

West Suburban Medical Center

River Forest, IL

Central Illinois Hematology Oncology Center

Springfield, IL

Rush - Copley Healthcare Center

Yorkville, IL

Southern Illinois University School of Medicine

Springfield, IL

Springfield Clinic

Springfield, IL

Memorial Medical Center

Springfield, IL

Cancer Care Specialists of Illinois (Swansea)

Swansea, IL

Carle Foundation Hospital

Urbana, IL

Northwestern Medicine Cancer Center Warrenville

Warrenville, IL

Crossroads Cancer Center

Effingham, IL

Illinois CancerCare (Eureka)

Eureka, IL

Cancer Center of Kansas (Chanute)

Chanute, KS

Cancer Center of Kansas (Wellington)

Wellington, KS

Cancer Center of Kansas (Winfield)

Winfield, KS

Wesley Medical Center

Wichita, KS

Associates In Womens Health

Wichita, KS

Cancer Center of Kansas (Wichita)

Wichita, KS

Cancer Center of Kansas (Salina)

Salina, KS

Cancer Center of Kansas (Pratt)

Pratt, KS

Cancer Center of Kansas (Newton)

Newton, KS

Franciscan Saint Anthony Health (Michigan City)

Michigan City, IN

Lawrence Memorial Hospital

Lawrence, KS

Cancer Center of Kansas (Kingman)

Kingman, KS

Cancer Center of Kansas (Independence)

Independence, KS

Cancer Center of Kansas (Fort Scott)

Fort Scott, KS

Cancer Center of Kansas (El Dorado)

El Dorado, KS

Cancer Center of Kansas (Dodge City)

Dodge City, KS

Cancer Center of Kansas (Parsons)

Parsons, KS

Bloomington Hospital (IU Health)

Bloomington, IN

Illinois CancerCare (Galesburg)

Galesburg, IL

Memorial Regional Cancer Center

Mishawaka, IN

Western Illinois Cancer Treatment Center

Galesburg, IL

Northwestern Medicine Cancer Center Delnor

Geneva, IL

Hinsdale Hematology Oncology Associates Incorporated

Hinsdale, IL

Presence Saint Mary's Hospital (Presence Health)

Kankakee, IL

Illinois CancerCare (Kewanee)

Kewanee, IL

Illinois CancerCare (Macomb)

Macomb, IL

Memorial Hospital of South Bend

South Bend, IN

Springmill Medical Center

Carmel, IN

Community Hospital

Munster, IN

Indiana University Health Ball Memorial Hospital

Muncie, IN

Reid Hospital and Health Care Services

Richmond, IN

Woodland Cancer Care Center

Michigan City, IN

Fort Wayne Medical Oncology and Hematology
Fort Wayne North Office

Fort Wayne, IN

Welch Cancer Center

Sheridan, WY

Not Currently Accepting Patients

The following is a listing of trial locations that are not currently open and accepting patients.

Mayo Clinic (Scottsdale)

Scottsdale, AZ

Mayo Clinic (Rochester)

Rochester, MN

Arizona
Mayo Clinic (Scottsdale)

Scottsdale, AZ

Arkansas
Mercy Cancer Center (Hot Springs)

Hot Springs National Park, AR

California
Kaiser Permanente (Antioch Medical Center)

Antioch, CA

Sutter Auburn Faith Hospital

Auburn, CA

Alta Bates Summit Comprehensive Cancer Center (Berkeley)

Berkeley, CA

Mills - Peninsula Medical Center

Burlingame, CA

Sutter Davis Hospital

Davis, CA

Kaiser Permanente (Fremont Medical Center)

Fremont, CA

Kaiser Permanente (Fresno Medical Center)

Fresno, CA

St. Jude Heritage Medical Group

Fullerton, CA

Rideout Cancer Center (Fremont)

Linda, CA

Palo Alto Medical Foundation (Santa Cruz)

Live Oak, CA

Memorial Medical Center

Modesto, CA

Kaiser Permanente (Modesto Medical Center)

Modesto, CA

Palo Alto Medical Foundation (Mountain View)

Mountain View, CA

Sutter Cancer Research Consortium

Novato, CA

Kaiser Permanente (Oakland Medical Center)

Oakland, CA

Palo Alto Medical Foundation Health Care (Palo Alto)

Palo Alto, CA

PCR Oncology

Pismo Beach, CA

Kaiser Permanente (Redwood City Medical Center)

Redwood City, CA

Kaiser Permanente (Richmond Medical Center)

Richmond, CA

Kaiser Permanente (Roseville Medical Center)

Roseville, CA

Sutter General Hospital

Sacramento, CA

Kaiser Permanente (South Sacramento Medical Center)

Sacramento, CA

Kaiser Permanente (Sacramento Medical Center)

Sacramento, CA

California Pacific Medical Center
Pacific Campus

San Francisco, CA