Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE) PROMISE

What's the purpose of this trial?

The PROMISE Study aims to establish a prospective cohort of individuals with precursor conditions to multiple myeloma, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).

This trial is currently open and accepting patients.

What will happen during the trial?

The goal of the PROMISE research study is to determine clinical/genomic alterations present in individuals with MGUS and SMM, who are diagnosed though screening of a high-risk population. We also seek to determine clinical/genomic/epigenetic and immune environmental predictors of progression to multiple myeloma in patients with MGUS and SMM.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  • Age ≥ 45 and ≤75
  • AA race (self-identified) and/or first-degree relative of a patient with plasma cell dyscrasia such as MGUS, SMM, multiple myeloma, and Waldenström Macroglobulinemia
  • Those over 18 are also eligible if they have 2 or more family members with a blood cancer

Exclusion Criteria:

  • Persons diagnosed with cancer at any site (including hematologic cancers) with symptomatic disease requiring active therapy

Additional Trial Information

Observational Trial

Enrollment: 30,000 patients (estimated)

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Trial Locations

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Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Open and Accepting


Dana-Farber Cancer Institute (Main)

Boston, MA

Open and Accepting
Interested in this trial?
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