Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

What's the purpose of this trial?


THE PROMISE study is the first study to test healthy people who may be at risk for early warning signs of a blood cancer called multiple myeloma.

We will further study people who test positive for these early warning signs of multiple myeloma so that we can learn how to prevent them from developing into cancer.


This study aims to make multiple myeloma a cancer that is preventable.

Who can join and get screened at no cost?

3 groups of U.S. adults, age 18-75, qualify for a free screening:

  1. African Americans AND / OR
  2. People of any race, age 45-75, who have a parent, sibling, or child with multiple myeloma or one these related conditions:
    • ​Monoclonal Gammopathy of Undetermined Significance (MGUS)
    • Smoldering Multiple Myeloma
    • Waldenström Macroglobulinemia
  3. People of any race, age 18 and older, who have 2 or more family members with a blood cancer

This trial is currently open and accepting patients.

What will happen during the trial?

No travel is required to participate in this observational trial.

Additional Trial Information

Enrollment: 50,000 patients (estimated)

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Trial Locations

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Dana-Farber Cancer Institute

Boston, MA

Open and Accepting
Interested in this trial?
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