Phase 3 Clinical Trial comparing the use of venetoclax combined with dexamethasone versus Pomalidomide combined with dexamethasone in Relapsed/Refractory Multiple Myeloma Patients with Translocation 11;14 CANOVA
Verified

What's the purpose of this trial?

The goal of this clinical trial is to compare the progression free survival of multiple myeloma patients with translocation 11;14 when treated with venetoclax and dexamethasone versus pomalidomide and dexamethasone. 

This trial is currently open and accepting patients.


What will happen during the trial?

This clinical trial is separated into two different groups, or arms. Participants will be randomly placed into one of the two arms. Both arms of the trial are organized into 28 day cycles. Participants may continue to receive the study treatments unless their myeloma gets worse, they develop bad side effects, or they no longer wish to participate.

Arm 1: Participants randomized into this arm will receive Venetoclax by mouth every day, and dexamethasone by mouth (or intravenously if unable to take by mouth) weekly. 

Arm 2: Participants randomized into this arm will receive Pomalidomide by mouth on days 1-21 of each 28 day cycle. Participants will also receive dexamethasone by mouth (or intravenously if unable to take by mouth) weekly. 

All participants will have a treatment completion visit and then move into follow up.

 

There may be an opportunity for participants to be reimbursed for some of their travel expenses for study related visits. Once a participant has established care at one of the study sites, the staff will share the details of potential reimbursement.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

You may be able to join this trial if you:

  • have measurable disease as described in the trial protocol.
  • have received at least two prior lines of therapy for multiple myeloma, with documented progression after last treatment. Participants must be relapsed/refractory to lenalidomide, and have previously received a proteasome inhibitor.
  • have tested positive for translocation 11;14 in a FISH assay performed by a centralized laboratory.
  • must not have previously received venetoclax, pomalidomide, or another BCL-2 inhibitor.
  • must not have received an allogeneic transplant in the previous 16 weeks, or an autologous transplant in the previous 12 weeks.
  • must not have known myeloma involvement in the central nervous system.

Additional Trial Information

Phase 3

Enrollment: 244 patients (estimated)

View More

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Arizona

University of Arizona Comprehensive Cancer Center

Tucson, AZ

Open and Accepting

California

VA Central California Health

Fresno, CA

Open and Accepting

UCLA Jonsson Comprehensive Cancer Center University of California Los Angeles

Los Angeles, CA

Open and Accepting

Colorado

VA Eastern Colorado Healthcare System

Aurora, CO

Open and Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Open and Accepting

Cleveland Clinic Florida

Weston, FL

Open and Accepting

Maryland

Massachusetts

Boston Medical Center

Boston, MA

Open and Accepting

Michigan

Henry Ford Hospital

Detroit, MI

Open and Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

Ohio

Cleveland Clinic Taussig Cancer Institute

Cleveland, OH

Open and Accepting

Cleveland Clinic (Fairview Hospital)

Cleveland, OH

Open and Accepting

Texas

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

Washington

VA Puget Sound Health Care System

Seattle, WA

Open and Accepting

Trial Links

Read the latest news and updates on this trial.

Interested in this trial?
  • Call us today 😀 keyboard_arrow_right

    We know how difficult and confusing this process can be. If you are interested in this clinical trial or have questions, you can call us at any time. You can also send us a direct message with questions.

    (888) 828-2206
  • If you are interested in keeping an eye on this trial, you can add it to your list of favorite trials. We'll send you alerts when this trial is updated.

  • Talk to your doctor keyboard_arrow_right

    You can print an overview of this trial to take in to your next appointment. Your doctor can help you understand if this trial may be right for you.

Still need help? Send us a message

SparkCures Verified

SparkCures is working closely with AbbVie to provide the most up-to-date information on this clinical trial. Use the button above to add this trial to your list of favorites.

Learn more about how we work with trial sponsors