This trial is being done to help determine if the investigative drug Iopofosine I 131 (CLR 131) is safe and can be tolerated for the treatment of multiple myeloma or certain lymphomas.
SparkCures ID | 871 |
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Trial Phase | Phase 2 |
Enrollment | 80 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Inclusion Criteria:
All Patients
Patients with Multiple Myeloma
Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Lymphoplasmacytic Lymphoma, or Marginal Zone Lymphoma
Patients with Mantle Cell Lymphoma
Patients with Diffuse Large B-Cell Lymphoma
Exclusion Criteria:
Please visit the ClinicalTrials.gov page for historical site information.
View CentersRead the latest news and updates on this trial.
December 01, 2022
December 16, 2019
December 09, 2019
The data from the oral presentation support prior literature and preclinical data showing that fractionated dosing provides an enhancement of efficacy and safety while reducing adverse events. The patients presented received one of 3 dose levels: a single bolus dose of 31.25 mCi/m2 or a fractionated dose of 31.25 mCi/m2 or a higher fractionated dose of 37.5 mCi/m2 of CLR 131. The fractionated 37.5 mCi/m2 dose of CLR 131 represents the greatest amount of drug administered to date in the Phase 2 CLOVER-1 trial. The overall response rate (ORR) for all multiple myeloma patients across the 3 dose cohorts was 31.3% and a 100% disease control rate. Patients receiving the higher fractionated 37.5 mCi/m2 dose demonstrated a 50% ORR with the remaining 50% having minimal responses (greater than a 25% reduction in the surrogate marker of efficacy).
November 04, 2019
October 01, 2019
May 13, 2019
Fast Track Designation is granted to drugs being developed for the treatment of serious or life-threatening diseases or conditions where there is an unmet medical need. The purpose of the Fast Track Designation provision is to help facilitate development and expedite the review of drugs to treat serious and life-threatening conditions.
February 25, 2019
Cellectar Biosciences, Inc., a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announced additional positive top-line results from its ongoing Phase 2 clinical study of CLR 131, the company’s lead product candidate.
February 02, 2019
Myeloma patients who had relapsed after receiving both a proteasome inhibitor (like Velcade) and immunomodulator (like Revlimid) participated in a Phase I study of a new drug called CLR 131 and experienced an average 22 month overall survival.
January 07, 2019
Cellectar Biosciences announced median overall survival (mOS) in Cohorts 1-4 of the company’s ongoing Phase 1 clinical trial...
October 02, 2018
Cellectar Biosciences today updates interim overall survival (OS) data from the company’s ongoing Phase 1b clinical trial evaluating CLR 131...
August 20, 2018
Cellectar Biosciences announces data from Cohort 5 of the company’s ongoing Phase 1b clinical trial evaluating CLR 131...
November 07, 2017
Cellectar Biosciences, Inc. today announces that the ongoing median overall survival (mOS) from Cohort 1 of the Phase 1 study...
May 26, 2016
Cellectar Biosciences has been issued a patent for its proprietary drug delivery technology, called phospholipid-ether drug conjugate (PDC).
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