This trial is being done to help determine if the investigative drug CLR 131 is safe and can be tolerated for the treatment of multiple myeloma or certain lymphomas.
This trial is currently open and accepting patients.
All patients enrolled in this phase 2 trial will receive the same treatment.
On the first day of the trial, you will receive a dose of CLR 131 through an intravenous infusion, and approximately one week later, you will receive a second dose. You will receive dexamethasone weekly as well, for up to three months.
You may be required to visit the study site upwards of 15 times over a three month period.
Patients may be eligible to a second cycle of CLR 131 if researchers think it will be safe and help your myeloma.
Patients may be eligible to receive financial assistance for travel and lodging purposes from Cellectar if enrolled in the study. Eligibility to receive financial assistance may vary depending on the site policies where a patient is planning to enroll.
Enrollment: 80 patients (estimated)View More
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required. Create your account or call us today for help (888) 828-2206.
December 09, 2019
Dr. Ailawadhi's presentation highlighted results from 19 patients with relapsed/refractory multiple myeloma from Cellectar’s Phase 1 and Phase 2 CLOVER-1 trial collected prior to July 30, 2019. The data from the oral presentation support prior literature and preclinical data showing that fractionated dosing provides an enhancement of efficacy and safety while reducing adverse events.
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December 16, 2019
December 09, 2019
The data from the oral presentation support prior literature and preclinical data showing that fractionated dosing provides an enhancement of efficacy and safety while reducing adverse events. The patients presented received one of 3 dose levels: a single bolus dose of 31.25 mCi/m2 or a fractionated dose of 31.25 mCi/m2 or a higher fractionated dose of 37.5 mCi/m2 of CLR 131. The fractionated 37.5 mCi/m2 dose of CLR 131 represents the greatest amount of drug administered to date in the Phase 2 CLOVER-1 trial. The overall response rate (ORR) for all multiple myeloma patients across the 3 dose cohorts was 31.3% and a 100% disease control rate. Patients receiving the higher fractionated 37.5 mCi/m2 dose demonstrated a 50% ORR with the remaining 50% having minimal responses (greater than a 25% reduction in the surrogate marker of efficacy).
November 04, 2019
October 01, 2019
September 27, 2019
May 13, 2019
Fast Track Designation is granted to drugs being developed for the treatment of serious or life-threatening diseases or conditions where there is an unmet medical need. The purpose of the Fast Track Designation provision is to help facilitate development and expedite the review of drugs to treat serious and life-threatening conditions.
February 25, 2019
Cellectar Biosciences, Inc., a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announced additional positive top-line results from its ongoing Phase 2 clinical study of CLR 131, the company’s lead product candidate.
February 02, 2019
Myeloma patients who had relapsed after receiving both a proteasome inhibitor (like Velcade) and immunomodulator (like Revlimid) participated in a Phase I study of a new drug called CLR 131 and experienced an average 22 month overall survival.
January 07, 2019
Cellectar Biosciences announced median overall survival (mOS) in Cohorts 1-4 of the company’s ongoing Phase 1 clinical trial...
October 02, 2018
Cellectar Biosciences today updates interim overall survival (OS) data from the company’s ongoing Phase 1b clinical trial evaluating CLR 131...
August 20, 2018
Cellectar Biosciences announces data from Cohort 5 of the company’s ongoing Phase 1b clinical trial evaluating CLR 131...
November 07, 2017
Cellectar Biosciences, Inc. today announces that the ongoing median overall survival (mOS) from Cohort 1 of the Phase 1 study...
May 26, 2016
Cellectar Biosciences has been issued a patent for its proprietary drug delivery technology, called phospholipid-ether drug conjugate (PDC).
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