CLR 131

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Overview

CLR 131 is a phospholipid drug conjugate (PDC) that selectively delivers radiation (a cytotoxic radioisotope called iodine-131) directly to malignant cancer cells. The US Food and Drug Administration (FDA) has granted Cellectar an orphan drug designation for CLR 131.

SparkCures ID 222
Developed By Cellectar Biosciences
Generic Name CLR 131
Additional Names I-131-CLR1404
Treatment Classifications
  • Phospholipid Drug Conjugate (PDC)
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Clinical Trials

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Early Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.

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An Open-Label, Multicenter, Phase 2 Study of CLR 131 in Patients with Relapsed or Refractory (R/R) Select B-Cell Malignancies
CLOVER-1
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Late Relapse Multiple Myeloma

The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.

Verified
An Open-Label, Multicenter, Phase 2 Study of CLR 131 in Patients with Relapsed or Refractory (R/R) Select B-Cell Malignancies
CLOVER-1
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Smoldering Myeloma
Monoclonal Gammopathy of Undetermined Significance (MGUS)

Published Results

Cellectar Reports Data on CLR 131 Phase 2 CLOVER-1 Study in Triple Class Refractory Multiple Myeloma Patients

September 09, 2020

The 40% ORR (6/15 patients) represents triple class refractory patients enrolled in Part A of Cellectar’s CLOVER-1 study and additional patients enrolled in Part B from March through May 2020. As a reminder, all patients being enrolled in Part B are required to be triple class refractory. The additional six patients were heavily pre-treated with an average of 9 prior multi-drug regimens. Three patients received a total administered dose of greater than 60 mCi and three received less than 60 mCi. Consistent with the data released in February 2020, patients receiving greater than 60 mCi exhibit strong responses. Patients continue to tolerate CLR 131 well, with the most common and almost exclusive treatment emergent adverse events being cytopenias and importantly, no unexpected adverse events have been reported.

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Resources

Cellectar Biosciences Expanded Access Policy

May 14, 2019

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Cellectar Announces Data From 20 Patients Receiving a Single 25mCi/M2 Bolus Dose of CLR 131 in th...

December 16, 2019

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Fractionated Dosing of CLR 131 in Patients with Relapsed or Refractory Multiple Myeloma Presented...

December 09, 2019

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Investigational Therapy Delivers Treatment to Patients with Multiple Myeloma in Two Doses

November 04, 2019

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Cellectar Biosciences’ New Radiosensitive Therapy in Multiple Myeloma with Natalie Callander, MD ...

October 01, 2019

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CLR 131 Granted Orphan Drug Status in Europe for Myeloma Treatment

September 27, 2019

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CLR 131 Achieves 50% Overall Response Rate in Cohort 6 of Ongoing Phase 1 Study in Relapsed or Re...

May 15, 2019

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Cellectar Receives FDA Fast Track Designation for CLR 131 in Relapsed or Refractory Multiple Myeloma

May 13, 2019

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Cellectar Reports Positive Top-line Response Rate of 30% from R/R Multiple Myeloma Cohort in Ongo...

February 25, 2019

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Overall Survival Lengthened for Relapsed/Refractory Myeloma Patients Using CLR 131 Cancer-Targete...

February 02, 2019

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Cellectar Provides Update on Phase 1 Trial of CLR 131 in Relapsed/Refractory Multiple Myeloma

January 07, 2019

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Cellectar Announces Overall Survival Exceeding 19 Months in Phase 1b Trial with CLR 131 in Relaps...

October 02, 2018

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Fractionated Dosing Improves Tolerability and Safety of Cellectar’s CLR 131 in R/R Multiple Myelo...

August 20, 2018

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Cellectar Announces Updated Median Overall Survival of 26.2 Months from Cohort 1 of CLR 131 Phase...

November 07, 2017

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Phospholipid-Ether Drug Conjugates: A Novel Vehicle Delivering Cytotoxic Small-Molecules

May 26, 2016

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