Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study EVOLVE

What's the purpose of this trial?

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Participants must have a confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (collectively referred to as CLL throughout) according to the 2018 International Workshop on CLL. Participants must have been diagnosed within 18 months prior to registration
* Participants must have CLL-International Prognostic Index (CLL-IPI) score \>= 4 and/or complex cytogenetics (defined as 3+ chromosomal abnormalities)
* Cytogenetic AND/OR FISH analyses must be completed at a Clinical Laboratory Improvement Act (CLIA)-approved (or laboratories accredited under Accreditation Canada Diagnostics to conduct FISH analyses) laboratory within 18 months prior to registration. At minimum, FISH panel should use probes to detect for abnormalities in chromosomes 13q, 12, 11q, and 17p
* TP53 gene mutation analysis performed at any CLIA-approved (or laboratories accredited under Accreditation Canada Diagnostics) lab (if completed) must be obtained within 18 months prior to registration. This sequencing test is distinct from FISH studies for del(17p)

* Note: TP53 gene mutation analysis is recommended but not required if the participant meets disease-related study criteria via a combination of risk factors that totals a score of 4 on the CLL-IPI score and/or has complex cytogenetics completed
* Immunoglobulin heavy chain locus variable (IgVH) gene mutation analysis performed at any CLIA-approved lab (or laboratories accredited under Accreditation Canada Diagnostics) must be obtained prior to registration (at any time prior to registration)
* Serum beta-2 microglobulin level must be obtained within 28 days prior to registration
* Participants must not meet any of the IWCLL specified criteria for active CLL therapy
* Treatment with high dose corticosteroids and/or intravenous immunoglobulin for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment
* Steroids used for treatment of conditions other than CLL/SLL must be at a dose of at most 20 mg/day of prednisone or equivalent corticosteroid at the time of registration
* Prior therapy with anti CD20 monoclonal antibodies is not allowed
* Participants must not have received or be currently receiving any prior CLL-directed therapy, including non-protocol-related therapy, anti-cancer immunotherapy, experimental therapy (with exception of agents approved for emergency access use for the prevention or treatment of COVID-19), or radiotherapy
* Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy
* Participants must be \>= 18 years of age
* Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
* Platelet count \>= 100,000/mm\^3 within 28 days prior to registration
* Absolute neutrophil count (ANC) \>= 1,000/mm\^3 within 28 days prior to registration
* Creatinine clearance \>= 30mL/min (by Cockcroft Gault) within 28 days prior to registration
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 3.0 x upper limit of normal (ULN) within 28 days prior to registration
* Total bilirubin =\< 2.0 x ULN (or 5.0 x ULN if the participant has a history of Gilbert's disease), within 28 days prior to registration
* Participants must be able to take oral medications
* Human immunodeficiency virus (HIV)-infected participants on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Participants with history of malignancy are allowed providing the cancer has not required active treatment within 2 years prior to registration (hormonal therapy is permissible). The following exceptions are permissible: basal cell, squamous cell skin, or non-melanomatous skin cancer, in situ cervical cancer, superficial bladder cancer not treated with intravesical chemotherapy or Bacillus Calmette-Guerin (BCG) within 6 months, localized prostate cancer requiring no more than chronic hormonal therapy, or localized breast cancer requiring no more than chronic hormonal therapy
* Participants must not have current, clinically significant gastrointestinal malabsorption, in the opinion of treating doctor
* Participants must not have cirrhosis
* Obinutuzumab has been associated with hepatitis reactivation. Participants must not have uncontrolled active infection with hepatitis B or C. Participants with latent hepatitis B infection must agree to take prophylaxis during and for 6 months following active protocol therapy with V-O.

* Active infection with hepatitis B or C:

* Active infection is defined as detectable hepatitis B deoxyribonucleic acid (DNA) or hepatitis C ribonucleic acid (RNA) by quantitative polymerase chain reaction (PCR).
* Latent infection with hepatitis B:

* Latent infection is defined as meeting all of the following criteria:

* Hepatitis B surface antigen positive
* Anti-hepatitis B total core antibody positive
* Anti-hepatitis IgM core antibody undetectable
* Hepatitis B PCR undetectable
* Participants with latent hepatitis B infection must agree to take prophylaxis with anti-hepatitis agents during and for 6 months following active protocol therapy with V-O.
* Participants who have received intravenous immunoglobulin (IVIG) therapy within 6 months who are hepatitis B core total antibody positive but PCR undetectable are not mandated to take prophylaxis
* Participants must not have had major surgery within 30 days prior registration or minor surgery within 7 days prior to registration. Examples of major surgery include neurosurgical procedures, joint replacements, and surgeries that occur inside the thoracic or abdomino-pelvic cavities. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. If a participant has had a bone marrow biopsy for diagnosis or evaluation of CLL, this will not exclude the participant from registration to the study. If there is a question about whether a surgery is major or minor, this should be discussed with the Study Chair
* Participants must not have known bleeding disorders (e.g., von Willebrand's disease or hemophilia)
* Participants must not have a history of stroke or intracranial hemorrhage within 6 months prior to enrollment
* Participants must not require continued therapy with a strong inhibitor or inducer of CYP3A4/5, as venetoclax is extensively metabolized by CYP3A4/5
* Participants must not have uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura
* Participants must not have any currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification
* Participants must not have a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to enrollment
* Participants must not be pregnant or nursing, as there are no safety data available for these drug regimens during pregnancy. Women/men of reproductive potential must have agreed to use an effective contraceptive method. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
* Participants must agree to have specimens submitted for translational medicine (MRD) as outlined
* Participants must be offered the opportunity to participate in specimen banking for future research as outlined.

* NOTE: With participant's consent, the site must follow through with specimen submission as outlined
* Participants who are able to complete patient reported outcome (PRO) forms in English, Spanish, French, German, Russian or Mandarin must agree to participate in the quality of life assessments. (Those participants who are unable to read and write in English, Spanish, French, German, Russian or Mandarin may be registered to S1925 without contributing to the quality of life portion of the study.)
* Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
* NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Additional Trial Information

Phase 3

Enrollment: 247 patients (estimated)

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Need Help?

Interested in joining or learning more about this trial?

(888) 828-2206

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alaska

Anchorage Associates in Radiation Medicine

Anchorage, AK

Temporarily Suspended

Anchorage Radiation Therapy Center

Anchorage, AK

Temporarily Suspended

Alaska Breast Care and Surgery LLC

Anchorage, AK

Temporarily Suspended

Alaska Oncology and Hematology LLC

Anchorage, AK

Temporarily Suspended

Alaska Women's Cancer Care

Anchorage, AK

Temporarily Suspended

Anchorage Oncology Centre

Anchorage, AK

Temporarily Suspended

Katmai Oncology Group

Anchorage, AK

Temporarily Suspended

Providence Alaska Medical Center

Anchorage, AK

Temporarily Suspended

Fairbanks Memorial Hospital

Fairbanks, AK

Open and Accepting

Arizona

Cancer Center at St. Joseph's

Phoenix, AZ

Temporarily Suspended

California

Kaiser Permanente Orange County - Anaheim Medical Center

Anaheim, CA

Open and Accepting

Dignity Health Mission Hope Cancer Center - Arroyo Grande

Arroyo Grande, CA

Temporarily Suspended

Kaiser Permanente Baldwin Park Medical Center

Baldwin Park, CA

Open and Accepting

Kaiser Permanente (Bellflower Medical Offices)

Bellflower, CA

Open and Accepting

Roy and Patricia Disney Family Cancer Center Providence Saint Joseph Medical Center

Burbank, CA

Temporarily Suspended

Marshall Cancer Center

Cameron Park, CA

Open and Accepting

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting

Mercy Cancer Center - Elk Grove

Elk Grove, CA

Open and Accepting

Kaiser Permanente (Fontana Medical Center)

Fontana, CA

Open and Accepting

Kaiser Permanente Orange County Irvine Medical Center

Irvine, CA

Open and Accepting

Rideout Cancer Center (Fremont)

Linda, CA

Open and Accepting

Kaiser Permanente (South Bay Medical Center)

Los Angeles, CA

Open and Accepting

Kaiser Permanente Los Angeles Medical Center

Los Angeles, CA

Open and Accepting

Kaiser Permanente (Panorama City Medical Center)

Los Angeles, CA

Open and Accepting

Kaiser Permanente (Woodland Hills Medical Center)

Los Angeles, CA

Open and Accepting

Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, CA

Open and Accepting

Kaiser Permanente (Riverside Medical Center)

Riverside, CA

Open and Accepting

Mercy Cancer Center - Rocklin

Rocklin, CA

Open and Accepting

Mercy Cancer Center

Sacramento, CA

Open and Accepting

University of California Davis Comprehensive Cancer Center

Sacramento, CA

Open and Accepting

Kaiser Permanente (San Diego Medical Center)

San Diego, CA

Open and Accepting

Kaiser Permanente (San Marcos Medical Offices)

San Marcos, CA

Open and Accepting

Mission Hope Cancer Center (Santa Maria) Central Coast Medical Oncology

Santa Maria, CA

Temporarily Suspended

Woodland Memorial Hospital

Woodland, CA

Open and Accepting

Colorado

Rocky Mountain Cancer Centers

Aurora, CO

Open and Accepting

The Medical Center of Aurora (HealthONE)

Aurora, CO

Temporarily Suspended

Rocky Mountain Cancer Center Boulder

Boulder, CO

Temporarily Suspended

Rocky Mountain Cancer Centers - Centennial

Centennial, CO

Open and Accepting

Littleton Adventist Hospital

Centennial, CO

Temporarily Suspended

Centura Penrose Hospital

Colorado Springs, CO

Temporarily Suspended

Rocky Mountain Cancer Center - Penrose Hospital Colorado Springs

Colorado Springs, CO

Temporarily Suspended

The Women's Imaging Center

Denver, CO

Temporarily Suspended

Porter Adventist Hospital

Denver, CO

Temporarily Suspended

Colorado Blood Cancer Institute Sarah Cannon at Presbyterian/St. Luke's Medical Center (HealthONE)

Denver, CO

Open and Accepting

Rocky Mountain Cancer Centers (Midtown)

Denver, CO

Open and Accepting

SCL Health Saint Joseph Hospital

Denver, CO

Temporarily Suspended

Rocky Mountain Cancer Centers (Rose Medical) Denver

Denver, CO

Open and Accepting

HealthOne Rose Medical Center

Denver, CO

Temporarily Suspended

Western Surgical Care

Denver, CO

Temporarily Suspended

Centura Mercy Hospital

Durango, CO

Temporarily Suspended

Centura Southwest Oncology

Durango, CO

Temporarily Suspended

The Melanoma and Skin Cancer Institute

Englewood, CO

Temporarily Suspended

Rocky Mountain Cancer Centers - Lakewood

Lakewood, CO

Temporarily Suspended

Centura St. Anthony Hospital

Lakewood, CO

Temporarily Suspended

Rocky Mountain Cancer Center Littleton

Littleton, CO

Open and Accepting

Rocky Mountain Cancer Centers - Sky Ridge Medical Center (Lone Tree) Lone Tree - Skyridge

Lone Tree, CO

Open and Accepting

HealthOne Sky Ridge Medical Center

Lone Tree, CO

Temporarily Suspended

Centura Longmont United Hospital

Longmont, CO

Temporarily Suspended

Centura Parker Adventist Hospital

Parker, CO

Temporarily Suspended

Saint Mary Corwin Medical Center

Pueblo, CO

Temporarily Suspended

Rocky Mountain Cancer Center - Thornton

Thornton, CO

Temporarily Suspended

Delaware

Beebe South Coastal Health Campus

Frankford, DE

Open and Accepting

Beebe Medical Center

Lewes, DE

Temporarily Suspended

Medical Oncology Hematology Consultants PA in ChristianaCare Helen F. Graham Cancer Center & Research Institute

Newark, DE

Open and Accepting

Christiana Care Health System (Christiana Hospital)

Newark, DE

Temporarily Suspended

Beebe Health Campus

Rehoboth Beach, DE

Open and Accepting

Florida

Holy Cross Hospital

Fort Lauderdale, FL

Open and Accepting

Idaho

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Open and Accepting

Saint Alphonsus Cancer Care Center (Caldwell)

Caldwell, ID

Open and Accepting

Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

Open and Accepting

Walter Knox Memorial Hospital

Emmett, ID

Temporarily Suspended

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

Temporarily Suspended

Idaho Urologic Institute

Meridian, ID

Temporarily Suspended

St. Luke's Cancer Institute (Meridian)

Meridian, ID

Temporarily Suspended

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Temporarily Suspended

Saint Alphonsus Cancer Care Center (Nampa)

Nampa, ID

Open and Accepting

Kootenai Cancer Center

Post Falls, ID

Open and Accepting

Saint Luke's Mountain States Tumor Institute (Twin Falls)

Twin Falls, ID

Temporarily Suspended

Illinois

OSF Saint Anthony's Health

Alton, IL

Temporarily Suspended

Rush - Copley Medical Center

Aurora, IL

Open and Accepting

Loyola Center for Health at Burr Ridge

Burr Ridge, IL

Temporarily Suspended

Memorial Hospital of Carbondale

Carbondale, IL

Temporarily Suspended

SIH Cancer Institute

Carterville, IL

Temporarily Suspended

Centralia Oncology Clinic

Centralia, IL

Temporarily Suspended

University of Chicago Medicine Comprehensive Cancer Center

Chicago, IL

Open and Accepting

Carle Foundation Hospital (Vermilion)

Danville, IL

Open and Accepting

Cancer Care Specialists of IL - Cancer Care Center of Decatur

Decatur, IL

Open and Accepting

Memorial Health - Decatur Memorial Hospital Memorial Health

Decatur, IL

Temporarily Suspended

Carle (Effingham)

Effingham, IL

Open and Accepting

Cancer Care Specialists (Crossroads Cancer Center)

Effingham, IL

Open and Accepting

Elmhurst Memorial Hospital

Elmhurst, IL

Open and Accepting

Western Illinois Cancer Treatment Center

Galesburg, IL

Temporarily Suspended

Northwestern Medicine Cancer Center Delnor

Geneva, IL

Open and Accepting

Loyola Medicine Homer Glen

Homer Glen, IL

Temporarily Suspended

Carle Foundation Hospital (Mattoon)

Mattoon, IL

Open and Accepting

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Open and Accepting

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, IL

Temporarily Suspended

Good Samaritan Regional Health Center

Mount Vernon, IL

Open and Accepting

Cancer Care Center of O'Fallon

O'Fallon, IL

Open and Accepting

Methodist Medical Center of Illinois

Peoria, IL

Temporarily Suspended

Southern Illinois University School of Medicine - Simmons Cancer Institute

Springfield, IL

Open and Accepting

Springfield Clinic Main Campus East

Springfield, IL

Open and Accepting

Memorial Medical Center

Springfield, IL

Temporarily Suspended

Carle Cancer Institute

Urbana, IL

Open and Accepting

Northwestern Medicine Cancer Center Warrenville

Warrenville, IL

Open and Accepting

Rush - Copley Healthcare Center

Yorkville, IL

Open and Accepting

Indiana

Reid Health

Richmond, IN

Open and Accepting

Iowa

Mary Greeley Medical Center

Ames, IA

Open and Accepting

McFarland Clinic PC

Ames, IA

Open and Accepting

McFarland Clinic PC (Boone)

Boone, IA

Open and Accepting

Saint Anthony Regional Hospital

Carroll, IA

Temporarily Suspended

Iowa Blood and Cancer Care of PCI

Cedar Rapids, IA

Open and Accepting

MercyOne Clive Cancer Center

Clive, IA

Temporarily Suspended

Alegent Health Mercy Hospital

Council Bluffs, IA

Temporarily Suspended

Greater Regional Medical Center

Creston, IA

Temporarily Suspended

Mission Cancer and Blood - Des Moines

Des Moines, IA

Open and Accepting

Broadlawns Medical Center

Des Moines, IA

Open and Accepting

MercyOne Des Moines Medical Center

Des Moines, IA

Open and Accepting

Mission Cancer MercyOne Cancer Center (Laurel)

Des Moines, IA

Temporarily Suspended

Iowa Lutheran Hospital

Des Moines, IA

Temporarily Suspended

McFarland Clinic Trinity Cancer Center

Fort Dodge, IA

Open and Accepting

McFarland Clinic PC (Jefferson)

Jefferson, IA

Open and Accepting

McFarland Clinic PC (Marshalltown)

Marshalltown, IA

Open and Accepting

MercyOne West Des Moines Medical Center

West Des Moines, IA

Temporarily Suspended

Kansas

Central Care Cancer Center (Heartland)

Garden City, KS

Temporarily Suspended

Central Care Cancer Center - Great Bend

Great Bend, KS

Temporarily Suspended

Hays Medical Center

Hays, KS

Open and Accepting

Lawrence Memorial Hospital

Lawrence, KS

Open and Accepting

Olathe Medical Center

Olathe, KS

Open and Accepting

University of Kansas Health System St. Francis Campus

Topeka, KS

Open and Accepting

Kentucky

Flaget Memorial Hospital

Bardstown, KY

Temporarily Suspended

Commonwealth Cancer Center (Corbin)

Corbin, KY

Temporarily Suspended

Saint Joseph Hospital

Lexington, KY

Temporarily Suspended

Saint Joseph Hospital East

Lexington, KY

Temporarily Suspended

Saint Joseph (London)

London, KY

Temporarily Suspended

Saints Mary and Elizabeth Hospital

Louisville, KY

Temporarily Suspended

Jewish Hospital Medical Center South

Shepherdsville, KY

Temporarily Suspended

Maryland

Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Open and Accepting

Walter Reed National Military Medical Center

Bethesda, MD

Open and Accepting

Massachusetts

Tufts Medical Center Cancer Center

Boston, MA

Open and Accepting

Dana-Farber Cancer Institute

Boston, MA

Open and Accepting

Michigan

Bronson Battle Creek Cancer Care Center

Battle Creek, MI

Open and Accepting

IHA Hematology Oncology at St. Joe's Brighton

Brighton, MI

Open and Accepting

St. Joseph Mercy Brighton Health Center

Brighton, MI

Open and Accepting

Henry Ford Institute - Brownstown

Brownstown Charter Township, MI

Temporarily Suspended

Michigan Cancer Research Consortium - Trinity Health Medical Center – Canton

Canton, MI

Open and Accepting

St. Joseph Mercy Canton Health Center

Canton, MI

Open and Accepting

Caro Cancer Center

Caro, MI

Temporarily Suspended

Chelsea Hospital Michigan Cancer Research Consortium

Chelsea, MI

Open and Accepting

IHA Hematology Oncology at St. Joe's Chelsea

Chelsea, MI

Open and Accepting

Hematology Oncology Consultants (Clarkston)

Clarkston, MI

Open and Accepting

Newland Medical Associates of Clarkston

Clarkston, MI

Open and Accepting

Henry Ford Macomb Hospital

Clinton Township, MI

Temporarily Suspended

Henry Ford Medical Center (Fairlane)

Dearborn, MI

Temporarily Suspended

Henry Ford Hospital

Detroit, MI

Open and Accepting

Great Lakes Cancer Management Specialists (Doctors Park)

East China, MI

Open and Accepting

Genesys Hurley Cancer Institute

Flint, MI

Open and Accepting

Hurley Medical Center

Flint, MI

Open and Accepting

Cancer Research Consortium of West Michigan - Spectrum Health Butterworth

Grand Rapids, MI

Open and Accepting

Trinity Health Grand Rapids Hospital

Grand Rapids, MI

Open and Accepting

Academic Hematology Oncology Specialists Ascension St. John Hospital

Grosse Pointe Woods, MI

Open and Accepting

Great Lakes Cancer Management Specialists (Van Elslander Cancer Center) Ascension St. John Hospital

Grosse Pointe Woods, MI

Open and Accepting

Ascension Medical Group Michigan Breast Specialists

Grosse Pointe Woods, MI

Temporarily Suspended

Allegiance Health

Jackson, MI

Temporarily Suspended

Bronson Methodist Hospital

Kalamazoo, MI

Open and Accepting

West Michigan Cancer Center

Kalamazoo, MI

Open and Accepting

Cancer Research Consortium of West Michigan - Ascension Borgess Cancer Medical Center

Kalamazoo, MI

Open and Accepting

Borgess Medical Center

Kalamazoo, MI

Temporarily Suspended

St. Mary Mercy Hospital St. Joe's Health

Livonia, MI

Open and Accepting

Great Lakes Cancer Management Specialists (Macomb Medical Campus)

Macomb, MI

Open and Accepting

Michigan Breast Specialists-Macomb Township

Macomb, MI

Temporarily Suspended

Michigan Cancer Research Consortium - Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, MI

Temporarily Suspended

Trinity Health Muskegon Hospital

Muskegon, MI

Open and Accepting

Cancer & Hematology Centers of Western Michigan - Muskegon

Norton Shores, MI

Open and Accepting

Henry Ford Medical Center (Columbus)

Novi, MI

Open and Accepting

Newland Medical Associates (Pontiac) The Alice Gustafson Center

Pontiac, MI

Open and Accepting

St. Joseph Mercy (Oakland)

Pontiac, MI

Open and Accepting

Ascension St. Mary's Hospital

Saginaw, MI

Open and Accepting

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, MI

Temporarily Suspended

Ascension Providence Cancer Center (Foster Winter Drive)

Southfield, MI

Open and Accepting

Bhadresh Nayak MD PC - Sterling Heights

Sterling Heights, MI

Open and Accepting

Ascension Saint Joseph Hospital

Tawas City, MI

Temporarily Suspended

Munson Medical Center

Traverse City, MI

Open and Accepting

Michigan Cancer Research Consortium - Advanced Breast Care Center PLLC

Warren, MI

Temporarily Suspended

Michigan Breast Specialists-Warren

Warren, MI

Temporarily Suspended

Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

Open and Accepting

University of Michigan Health - West

Wyoming, MI

Open and Accepting

Huron Gastroenterology PC

Ypsilanti, MI

Open and Accepting

Minnesota

M Health Fairview Ridges Hospital

Burnsville, MN

Temporarily Suspended

Minnesota Oncology - Burnsville

Burnsville, MN

Temporarily Suspended

Cambridge Medical Center

Cambridge, MN

Temporarily Suspended

Mercy Hospital

Coon Rapids, MN

Open and Accepting

Essentia Health

Deer River, MN

Open and Accepting

Essentia Health (Duluth Clinic)

Duluth, MN

Open and Accepting

Fairview Southdale Hospital

Edina, MN

Temporarily Suspended

Essentia Health Hibbing Clinic

Hibbing, MN

Open and Accepting

Fairview Maple Grove Medical Center

Maple Grove, MN

Temporarily Suspended

Minnesota Oncology Maplewood Cancer Center

Maplewood, MN

Temporarily Suspended

Abbott-Northwestern Hospital Allina Health Cancer Institute

Minneapolis, MN

Temporarily Suspended

Hennepin County Medical Center

Minneapolis, MN

Temporarily Suspended

Minneapolis VA Medical Center

Minneapolis, MN

Temporarily Suspended

Health Partners Inc.

Minneapolis, MN

Temporarily Suspended

Monticello Cancer Center

Monticello, MN

Temporarily Suspended

New Ulm Medical Center

New Ulm, MN

Temporarily Suspended

Fairview Northland Medical Center

Princeton, MN

Temporarily Suspended

North Memorial Medical Health Center

Robbinsdale, MN

Temporarily Suspended

Essentia Health (Sandstone)

Sandstone, MN

Open and Accepting

Saint Francis Regional Medical Center

Shakopee, MN

Temporarily Suspended

Coborn Cancer Center at Saint Cloud Hospital

St. Cloud, MN

Open and Accepting

Regions Hospital

St. Paul, MN

Temporarily Suspended

United Hospital

St. Paul, MN

Temporarily Suspended

Lakeview Hospital

Stillwater, MN

Temporarily Suspended

Essentia Health Virginia Clinic

Virginia, MN

Open and Accepting

Ridgeview Medical Center

Waconia, MN

Open and Accepting

Rice Memorial Hospital

Willmar, MN

Temporarily Suspended

Minnesota Oncology and Hematology PA (Woodbury)

Woodbury, MN

Temporarily Suspended

Fairview Lakes Medical Center

Wyoming, MN

Temporarily Suspended

Missouri

Saint Louis Cancer and Breast Institute

Ballwin, MO

Temporarily Suspended

Central Care Cancer Center

Bolivar, MO

Temporarily Suspended

Saint Francis Medical Center (Cape Girardeau)

Cape Girardeau, MO

Open and Accepting

Southeast Cancer Center Southeast Health

Cape Girardeau, MO

Temporarily Suspended

Parkland Health Center (Farmington)

Farmington, MO

Open and Accepting

Freeman Cornell-Beshore Cancer Institute

Joplin, MO

Temporarily Suspended

Mercy Hospital Joplin

Joplin, MO

Temporarily Suspended

Mercy Clinic Cancer and Hematology (Rolla)

Rolla, MO

Temporarily Suspended

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, MO

Open and Accepting

Mercy Hospital Springfield

Springfield, MO

Temporarily Suspended

CoxHealth South Hospital Cox Medical Center South

Springfield, MO

Temporarily Suspended

Heartland Regional Medical Center

St. Joseph, MO

Temporarily Suspended

Saint Louis Cancer and Breast Institute (South City)

St. Louis, MO

Temporarily Suspended

Mercy Hospital South

St. Louis, MO

Open and Accepting

Missouri Baptist Medical Cancer Center

St. Louis, MO

Open and Accepting

Mercy Hospital St. Louis David C. Pratt Cancer Center

St. Louis, MO

Open and Accepting

Missouri Baptist Sullivan Hospital

Sullivan, MO

Open and Accepting

Mercy Hospital Washington

Washington, MO

Temporarily Suspended

Montana

Community Hospital of Anaconda

Anaconda, MT

Open and Accepting

Billings Clinic Cancer Center

Billings, MT

Open and Accepting

Benefis Sletten Cancer Institute

Great Falls, MT

Open and Accepting

Great Falls Clinic Specialty Center

Great Falls, MT

Temporarily Suspended

Kalispell Regional Medical Center

Kalispell, MT

Temporarily Suspended

Providence St. Patrick Hospital

Missoula, MT

Temporarily Suspended

Nebraska

Nebraska Cancer Specialists (Grand Island)

Grand Island, NE

Temporarily Suspended

CHI Health Good Samaritan Hospital

Kearney, NE

Temporarily Suspended

CHI Health St. Elizabeth St. Elizabeth Regional Medical Center

Lincoln, NE

Temporarily Suspended

CHI Health Creighton University Medical Center

Omaha, NE

Temporarily Suspended

CHI Health Midlands

Papillion, NE

Temporarily Suspended

Nevada

OptumCare Cancer Care at Seven Hills

Henderson, NV

Open and Accepting

Optum Care Cancer Center - Charleston

Las Vegas, NV

Open and Accepting

OptumCare Cancer Care at Fort Apache

Las Vegas, NV

Open and Accepting

New Hampshire

Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center

Lebanon, NH

Open and Accepting

New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

Rutgers Cancer Institute of New Jersey Rutgers, The State University of New Jersey

New Brunswick, NJ

Open and Accepting

New Mexico

University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

Herbert Irving Comprehensive Cancer Center (Columbia University) Columbia University Medical Center

New York, NY

Open and Accepting

University of Rochester Medical Center Wilmot Cancer Center Strong Memorial Hospital

Rochester, NY

Open and Accepting

SUNY Upstate Medical University State University of New York

Syracuse, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Temporarily Suspended

Southeastern Medical Oncology Center (Clinton)

Clinton, NC

Open and Accepting

Durham Veterans Affairs Medical Center

Durham, NC

Open and Accepting

Duke Cancer Center Duke University Medical Center

Durham, NC

Temporarily Suspended

Southeastern Medical Oncology Center (Goldsboro)

Goldsboro, NC

Open and Accepting

UNC Hospitals Hillsborough

Hillsborough, NC

Open and Accepting

Southeastern Medical Oncology Center (Jacksonville)

Jacksonville, NC

Open and Accepting

Ohio

Strecker Cancer Center (Belpre)

Belpre, OH

Open and Accepting

Saint Elizabeth Boardman Hospital

Boardman, OH

Temporarily Suspended

Adena Regional Medical Center

Chillicothe, OH

Open and Accepting

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Temporarily Suspended

Oncology Hematology Care Inc. (Kenwood)

Cincinnati, OH

Temporarily Suspended

TriHealth Bethesda North Hospital

Cincinnati, OH

Temporarily Suspended

Cleveland Clinic (Fairview Hospital)

Cleveland, OH

Open and Accepting

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Open and Accepting

Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute

Columbus, OH

Open and Accepting

Columbus Oncology and Hematology Associates

Columbus, OH

Temporarily Suspended

OhioHealth Riverside Methodist Hospital

Columbus, OH

Temporarily Suspended

OhioHealth Grant Medical Center

Columbus, OH

Temporarily Suspended

The Mark H. Zangmeister Center

Columbus, OH

Open and Accepting

Mount Carmel Health Center West

Columbus, OH

Temporarily Suspended

Doctors Hospital

Columbus, OH

Temporarily Suspended

Miami Valley Hospital

Dayton, OH

Temporarily Suspended

Greater Dayton Cancer Center Dayton Physicians

Dayton, OH

Open and Accepting

OhioHealth Grady Memorial Hospital Cancer Center

Delaware, OH

Temporarily Suspended

Dublin Methodist Hospital

Dublin, OH

Temporarily Suspended

Armes Family Cancer Center

Findlay, OH

Open and Accepting

Blanchard Valley Hospital Orion Cancer Center

Findlay, OH

Temporarily Suspended

TriHealth Cancer Institute (Anderson)

Forestville, OH

Temporarily Suspended

Dayton Physicians (Atrium Medical Center)

Franklin, OH

Open and Accepting

Central Ohio Breast and Endocrine Surgery

Gahanna, OH

Temporarily Suspended

Dayton Physicians LLC-Wayne

Greenville, OH

Temporarily Suspended

Wayne Healthcare

Greenville, OH

Temporarily Suspended

Mount Carmel Grove City Hospital

Grove City, OH

Temporarily Suspended

Kettering Cancer Care

Kettering, OH

Open and Accepting

Fairfield Medical Center

Lancaster, OH

Temporarily Suspended

Saint Rita's Medical Center

Lima, OH

Temporarily Suspended

OhioHealth Mansfield Hospital

Mansfield, OH

Temporarily Suspended

Marietta Memorial Hospital

Marietta, OH

Open and Accepting

OhioHealth Marion General Hospital

Marion, OH

Temporarily Suspended

Memorial Hospital

Marysville, OH

Open and Accepting

Cleveland Clinic (Hillcrest Hospital)

Mayfield Heights, OH

Open and Accepting

Knox Community Hospital

Mount Vernon, OH

Temporarily Suspended

Licking Memorial Hospital

Newark, OH

Open and Accepting

Newark Radiation Oncology

Newark, OH

Temporarily Suspended

Mercy Health Perrysburg Cancer Center

Perrysburg, OH

Temporarily Suspended

Southern Ohio Medical Center

Portsmouth, OH

Open and Accepting

Springfield Regional Medical Center

Springfield, OH

Open and Accepting

Mercy Health - St. Anne Hospital

Toledo, OH

Temporarily Suspended

Toledo Clinic Cancer Centers - Toledo

Toledo, OH

Temporarily Suspended

Dayton Physicians - Upper Valley Medical Center

Troy, OH

Temporarily Suspended

Saint Joseph Warren Hospital

Warren, OH

Temporarily Suspended

Saint Ann's Hospital

Westerville, OH

Temporarily Suspended

TriHealth Cancer Institute (Westside)

White Oak, OH

Temporarily Suspended

Mount Carmel Health Center (East)

Whitehall, OH

Temporarily Suspended

Wright-Patterson Medical Center

Wright-Patterson AFB, OH

Open and Accepting

Saint Elizabeth Youngstown Hospital

Youngstown, OH

Temporarily Suspended

Genesis HealthCare System

Zanesville, OH

Open and Accepting

Oklahoma

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Open and Accepting

Mercy Hospital Oklahoma City

Oklahoma City, OK

Temporarily Suspended

Oregon

St. Charles (Bend Campus)

Bend, OR

Temporarily Suspended

Clackamas Radiation Oncology Center

Clackamas, OR

Open and Accepting

Providence Cancer Institute Clackamas Clinic

Clackamas, OR

Open and Accepting

Bay Area Hospital

Coos Bay, OR

Temporarily Suspended

Providence Newberg Medical Center

Newberg, OR

Open and Accepting

Providence Willamette Falls Medical Center

Oregon City, OR

Open and Accepting

Providence Oncology and Hematology - Eastside Providence Cancer Institute Franz Clinic

Portland, OR

Open and Accepting

Saint Charles Health System (Redmond)

Redmond, OR

Temporarily Suspended

Pennsylvania

Lehigh Valley Hospital-Cedar Crest

Allentown, PA

Open and Accepting

Lehigh Valley Hospital - Muhlenberg

Bethlehem, PA

Open and Accepting

Christiana Care Health System-Concord Health Center

Chadds Ford, PA

Temporarily Suspended

Geisinger Medical Center - Danville

Danville, PA

Open and Accepting

Pocono Medical Center

East Stroudsburg, PA

Temporarily Suspended

Lehigh Valley Hospital - Hazleton

Hazleton, PA

Temporarily Suspended

Thomas Jefferson University Hospital

Philadelphia, PA

Open and Accepting

Geisinger Wyoming Valley Medical Center Henry Cancer Center

Wilkes-Barre, PA

Open and Accepting

South Carolina

Medical University of South Carolina

Charleston, SC

Open and Accepting

Tennessee

Baptist Clinical Research Institute

Memphis, TN

Open and Accepting

Vanderbilt-Ingram Cancer Center Henry-Joyce Cancer Clinic

Nashville, TN

Open and Accepting

Texas

St. Joseph Regional Cancer Center

Bryan, TX

Temporarily Suspended

UT Southwestern Clinical Center at Richardson/Plano

Richardson, TX

Open and Accepting

Washington

Providence Regional Cancer System (Aberdeen)

Aberdeen, WA

Temporarily Suspended

PeaceHealth Medical Group

Bellingham, WA

Temporarily Suspended

St. Michael - Harrison Medical Center

Bremerton, WA

Open and Accepting

Highline Medical Center (Main Campus)

Burien, WA

Temporarily Suspended

Providence Regional Cancer System (Centralia)

Centralia, WA

Temporarily Suspended

Swedish Cancer Institute Swedish Edmonds Campus

Edmonds, WA

Open and Accepting

Saint Elizabeth Hospital

Enumclaw, WA

Temporarily Suspended

Providence Everett Medical Center

Everett, WA

Temporarily Suspended

Saint Francis Hospital

Federal Way, WA

Temporarily Suspended

Swedish Cancer Institute

Issaquah, WA

Open and Accepting

Kadlec Clinic Hematology and Oncology

Kennewick, WA

Open and Accepting

Providence Regional Cancer System (Lacey)

Lacey, WA

Temporarily Suspended

Saint Clare Hospital - CHI Franciscan Health

Lakewood, WA

Temporarily Suspended

Saint John Medical Center

Longview, WA

Temporarily Suspended

Jefferson Healthcare

Port Townsend, WA

Temporarily Suspended

Swedish Medical Center (Ballard Campus)

Seattle, WA

Temporarily Suspended

Fred Hutchinson Cancer Research Center University of Washington Cancer Consortium / SCCA

Seattle, WA

Open and Accepting

Swedish Cancer Institute - Cherry Hill Campus

Seattle, WA

Temporarily Suspended

Swedish - First Hill Campus

Seattle, WA

Open and Accepting

PeaceHealth United General Medical Center

Sedro-Woolley, WA

Temporarily Suspended

Providence Regional Cancer System (Shelton)

Shelton, WA

Temporarily Suspended

Virginia Mason Franciscan Health Research Center (Tacoma) CHI Franciscan

Tacoma, WA

Temporarily Suspended

PeaceHealth Southwest Medical Center

Vancouver, WA

Open and Accepting

Providence St. Mary Regional Cancer Center

Walla Walla, WA

Temporarily Suspended

North Star Lodge Cancer Center

Yakima, WA

Open and Accepting

Providence Regional Cancer System (Yelm)

Yelm, WA

Temporarily Suspended

Washington, D.C.

Sibley Memorial Hospital The Johns Hopkins Hospital

Washington, DC

Open and Accepting

Wisconsin

Langlade Hospital and Cancer Center

Antigo, WI

Open and Accepting

ThedaCare Regional Cancer Center

Appleton, WI

Open and Accepting

Essentia Health - Ashland Clinic

Ashland, WI

Open and Accepting

HSHS Sacred Heart Hospital

Eau Claire, WI

Open and Accepting

Marshfield Medical Center Cancer Center - Eau Claire

Eau Claire, WI

Open and Accepting

Gundersen Lutheran Medical Center

La Crosse, WI

Open and Accepting

Marshfield Medical Center - Hospital

Marshfield, WI

Open and Accepting

Aspirus Medford Hospital

Medford, WI

Open and Accepting

Marshfield Clinic (Minocqua Center)

Minocqua, WI

Open and Accepting

Cancer Center of Western Wisconsin

New Richmond, WI

Temporarily Suspended

HSHS St. Vincent Hospital Cancer Centers at HSHS St. Clare Hospital

Oconto Falls, WI

Open and Accepting

Marshfield Clinic (Rice Lake Center)

Rice Lake, WI

Open and Accepting

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, WI

Open and Accepting

Marshfield Clinic Cancer Care (Saint Michael's Hospital)

Stevens Point, WI

Open and Accepting

Aspirus Regional Cancer Center

Wausau, WI

Open and Accepting

Marshfield Medical Center St. Clare's Hospital

Weston, WI

Open and Accepting

Wyoming

Cheyenne Regional Medical Center (West)

Cheyenne, WY

Temporarily Suspended

Billings Clinic (Cody)

Cody, WY

Temporarily Suspended

Welch Cancer Center

Sheridan, WY

Temporarily Suspended
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