Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias PEDAL SCREENING

What's the purpose of this trial?

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

This trial is currently open and accepting patients.


What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Patients must be less than 22 years of age at the time of study enrollment
* Patient must have one of the following:

* Patient has known or suspected relapsed/refractory (including primary refractory) AML

* This includes isolated myeloid sarcoma
* Patient has known or suspected relapsed/refractory (including primary refractory) myeloid leukemia of Down syndrome
* Patient has known or suspected relapsed ALL that meets one of the following criteria:

* Second or greater B-ALL medullary relapse, excluding KMT2Ar.
* Any first or greater B-ALL medullary relapse involving KMT2Ar.
* Any first or greater T-ALL medullary relapse with or without KMT2Ar.
* Patient has known or suspected relapsed/refractory (including primary refractory) mixed phenotype acute leukemia (MPAL)
* Patient has known or suspected de novo or relapsed/refractory (including primary refractory) treatment-related AML (t-AML) or treatment-related myelodysplastic syndrome (t-MDS)
* Patient has known or suspected de novo or relapsed/refractory (including primary refractory) myelodysplastic syndrome (MDS)
* Patient has known or suspected de novo or relapsed/refractory (including primary refractory) juvenile myelomonocytic leukemia (JMML)
* All patients and/or their parents or legal guardians must sign a written informed consent
* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Additional Trial Information

Phase 1/2

Enrollment: 960 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

Children's of Alabama

Birmingham, AL

Open and Accepting

USA Health Strada Patient Care Center

Mobile, AL

Open and Accepting

Alaska

Providence Alaska Medical Center

Anchorage, AK

Open and Accepting

Arizona

Banner Children's at Desert

Mesa, AZ

Open and Accepting

Phoenix Children's Hospital

Phoenix, AZ

Open and Accepting

Banner Health University Medical Center

Tucson, AZ

Temporarily Suspended

Arkansas

Arkansas Children's Hospital

Little Rock, AR

Open and Accepting

California

Loma Linda University Cancer Center

Loma Linda, CA

Open and Accepting

Miller Children's and Women's Hospital Long Beach

Long Beach, CA

Open and Accepting

Children's Hospital Los Angeles

Los Angeles, CA

Open and Accepting

Valley Children's Hospital

Madera, CA

Open and Accepting

UCSF Benioff Children's Hospital Oakland

Oakland, CA

Open and Accepting

Kaiser Permanente - Oakland Medical Center

Oakland, CA

Open and Accepting

Children's Hospital Orange County

Orange, CA

Open and Accepting

Stanford Univ Med Ctr. / Lucile Packard Children's Hosp

Palo Alto, CA

Open and Accepting

Rady Children's Hospital

San Diego, CA

Not Yet Accepting

Colorado

The Children's Hospital of Colorado

Aurora, CO

Open and Accepting

Rocky Mountain Cancer Centers (Midtown)

Denver, CO

Open and Accepting

Connecticut

Connecticut Children's Medical Center

Hartford, CT

Open and Accepting

Smilow Cancer Hospital at Yale New Haven

New Haven, CT

Open and Accepting

Delaware

Alfred I. DuPont Hospital for Children

Wilmington, DE

Open and Accepting

Florida

Broward Oncology Associates, PA

Fort Lauderdale, FL

Open and Accepting

Golisano Children's Hospital of Southwest Florida

Fort Myers, FL

Open and Accepting

Shands Hospital University of Florida Health

Gainesville, FL

Open and Accepting

Joe DiMaggio Children's Hospital Memorial Regional Hospital

Hollywood, FL

Open and Accepting

Nemour's Children's Health (Jacksonville)

Jacksonville, FL

Open and Accepting

Nicklaus Children's Hospital

Miami, FL

Open and Accepting

Nemours Children's Hospital

Orlando, FL

Open and Accepting

Sacred Heart Medical Oncology Group

Pensacola, FL

Open and Accepting

Johns Hopkins All Children's Hospital

Saint Petersburg, FL

Open and Accepting

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, FL

Open and Accepting

Saint Mary's Hospital

West Palm Beach, FL

Open and Accepting

Georgia

Children's Healthcare of Atlanta Egleston Hospital

Atlanta, GA

Open and Accepting

Memorial Health University Medical Center

Savannah, GA

Open and Accepting

Hawaii

Kapiolani Medical Center for Women and Children

Honolulu, HI

Open and Accepting

Illinois

University of Chicago Medicine Comprehensive Cancer Center

Chicago, IL

Open and Accepting

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Open and Accepting

Saint Jude Midwest Affiliate

Peoria, IL

Open and Accepting

Southern Illinois University School of Medicine - Simmons Cancer Institute

Springfield, IL

Open and Accepting

Indiana

Simon Cancer Center Indiana University

Indianapolis, IN

Open and Accepting

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, IN

Open and Accepting

Iowa

Blank Children's Hospital

Des Moines, IA

Open and Accepting

Kentucky

UK Markey Cancer Center University of Kentucky

Lexington, KY

Open and Accepting

Norton Cancer Institute (St. Matthews) St. Matthews Campus

Louisville, KY

Open and Accepting

Louisiana

Ochsner Medical Center

Jefferson, LA

Open and Accepting

Children's Hospital New Orleans

New Orleans, LA

Open and Accepting

Maine

Maine Children's Cancer Program

Scarborough, ME

Open and Accepting

Maryland

Sinai Hospital LifeBridge Health

Baltimore, MD

Open and Accepting

Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Open and Accepting

Walter Reed National Military Medical Center

Bethesda, MD

Temporarily Suspended

Massachusetts

Dana-Farber Cancer Institute (Main)

Boston, MA

Open and Accepting

Michigan

University of Michigan Comprehensive Cancer Center Rogel Cancer Center

Ann Arbor, MI

Open and Accepting

Children's Hospital of Michigan

Detroit, MI

Open and Accepting

Michigan State University Clinical Center

East Lansing, MI

Open and Accepting

Spectrum Health

Grand Rapids, MI

Open and Accepting

Bronson Methodist Hospital

Kalamazoo, MI

Open and Accepting

Beaumont Children's Hospital-Royal Oak

Royal Oak, MI

Open and Accepting

Minnesota

Children's Hospitals and Clinics of Minnesota

Minneapolis, MN

Open and Accepting

University of Minnesota - Masonic Cancer Center

Minneapolis, MN

Open and Accepting

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

Mississippi

University of Mississippi Medical Center

Jackson, MS

Open and Accepting

Missouri

Children's Mercy Hospitals and Clinics

Kansas City, MO

Open and Accepting

Cardinal Glennon Children's Medical Center

Saint Louis, MO

Open and Accepting

Mercy Hospital St. Louis David C. Pratt Cancer Center

St. Louis, MO

Open and Accepting

Nebraska

Children's Hospital and Medical Center of Omaha

Omaha, NE

Open and Accepting

Nevada

Cure 4 the Kids Foundation Roseman University of Health Sciences

Las Vegas, NV

Open and Accepting

Summerlin Hospital Medical Center

Las Vegas, NV

Open and Accepting

Renown Regional Medical Center

Reno, NV

Open and Accepting

New Hampshire

Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center

Lebanon, NH

Open and Accepting

New Jersey

Morristown Medical Center Atlantic Health System

Morristown, NJ

Open and Accepting

Rutgers Cancer Institute of New Jersey Rutgers, The State University of New Jersey

New Brunswick, NJ

Temporarily Suspended

St. Joseph’s University Medical Center

Paterson, NJ

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Albany Medical Cancer Center

Albany, NY

Open and Accepting

NYU Langone - Long Island

Mineola, NY

Open and Accepting

Maimonides Cancer Center

New York, NY

Open and Accepting

Steven and Alexandra Cohen Children's Medical Center Northwell Health

Queens, NY

Open and Accepting

Stony Brook University Hospital

Stony Brook, NY

Open and Accepting

SUNY Upstate Medical University State University of New York

Syracuse, NY

Open and Accepting

Montefiore Medical Center (Moses Campus)

The Bronx, NY

Open and Accepting

Westchester Medical Center New York Medical College

Valhalla, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Open and Accepting

Wake Forest Baptist - Comprehensive Cancer Center Atrium Health

Winston-Salem, NC

Open and Accepting

Mission Hospital Inc Memorial Campus

Asheville, NC

Open and Accepting

Carolinas Medical Center

Charlotte, NC

Open and Accepting

Duke Cancer Center Duke University Medical Center

Durham, NC

Open and Accepting

East Carolina University Vidant Cancer Care Eddie and Jo Allison Smith Tower

Greenville, NC

Open and Accepting

Ohio

Cincinnati Children's Hospital Medical Center

Cincinnati, OH

Open and Accepting

Rainbow Babies and Childrens Hospital

Cleveland, OH

Open and Accepting

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Open and Accepting

Nationwide Children's Hospital

Columbus, OH

Open and Accepting

Dayton Children's Hospital

Dayton, OH

Open and Accepting

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, OH

Temporarily Suspended

Oklahoma

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Open and Accepting

Oregon

Legacy Emanuel Children's Hospital

Portland, OR

Open and Accepting

Oregon Health and Science University OHSU Knight Cancer Institute

Portland, OR

Open and Accepting

Pennsylvania

Lehigh Valley Hospital-Cedar Crest

Allentown, PA

Open and Accepting

Geisinger Medical Center - Danville

Danville, PA

Open and Accepting

Children's Hospital of Philadelphia

Philadelphia, PA

Open and Accepting

Saint Christopher's Hospital for Children

Philadelphia, PA

Open and Accepting

UPMC Children's Hospital of Pittsburgh

Pittsburgh, PA

Open and Accepting

Rhode Island

Lifespan Rhode Island Hospital

Providence, RI

Open and Accepting

South Carolina

Medical University of South Carolina

Charleston, SC

Open and Accepting

Prisma Health - Richland Hospital

Columbia, SC

Open and Accepting

BI-LO Charities Children's Cancer Center

Greenville, SC

Open and Accepting

South Dakota

Sanford USD Medical Center (Sioux Falls)

Sioux Falls, SD

Open and Accepting

Tennessee

East Tennessee Childrens Hospital

Knoxville, TN

Open and Accepting

St. Jude Children's Research Center

Memphis, TN

Open and Accepting

Vanderbilt-Ingram Cancer Center Henry-Joyce Cancer Clinic

Nashville, TN

Open and Accepting

Texas

Dell Children's Medical Center of Central Texas

Austin, TX

Open and Accepting

Driscoll Children's Hospital

Corpus Christi, TX

Open and Accepting

Medical City Dallas Hospital

Dallas, TX

Open and Accepting

El Paso Children's Hospital

El Paso, TX

Open and Accepting

Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center

Houston, TX

Open and Accepting

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

UMC Cancer Center / UMC Health System

Lubbock, TX

Open and Accepting

Children's Hospital of San Antonio

San Antonio, TX

Open and Accepting

Methodist Children's Hospital of South Texas

San Antonio, TX

Open and Accepting

Utah

Primary Children's Hospital

Salt Lake City, UT

Open and Accepting

Virginia

UVA Cancer Center University of Virginia Health System

Charlottesville, VA

Open and Accepting

Inova Fairfax Medical Hospital Inova Schar Cancer Institute

Falls Church, VA

Open and Accepting

Children's Hospital of The King's Daughters

Norfolk, VA

Open and Accepting

Massey Cancer Center Virginia Commonwealth University (VCU Health)

Richmond, VA

Open and Accepting

Carilion Children's

Roanoke, VA

Open and Accepting

Washington

Seattle Children's Hospital

Seattle, WA

Open and Accepting

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, WA

Open and Accepting

Mary Bridge Children's Hospital and Health Center

Tacoma, WA

Open and Accepting

Madigan Army Medical Center

Tacoma, WA

Open and Accepting

Washington, D.C.

Children's National Medical Center

Washington, DC

Open and Accepting

West Virginia

WVU Cancer Institute Mary Babb Randolph Cancer Center

Morgantown, WV

Temporarily Suspended

Wisconsin

Marshfield Medical Center - Hospital

Marshfield, WI

Open and Accepting
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