Multiple Myeloma Support + Trials

What's the purpose of this trial?

The purpose of the study is to compare CC-92480 (BMS-986348) with carfilzomib and dexamethasone (480Kd) against carfilzomib and dexamethasone (Kd) in the treatment of relapsed or refractory multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following:
- Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or
- M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or,
- For participants without measurable disease in sPEP or uPEP: serum free light chain levels > 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio .
Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, [with or without] hematopoietic stem cell transplant, (with or without) consolidation, and/or [with or without] maintenance therapy).
Participant must have received prior treatment with lenalidomide and an anti-CD38 monoclonal antibody.
Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy.
Participant must have documented disease progression during or after their last antimyeloma regimen.

Exclusion Criteria:

Participant who has had prior treatment with CC-92480 or carfilzomib.
Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment.

Additional protocol-defined criteria apply.

Additional Trial Information

Phase 3

Enrollment: 525 patients (estimated)

Need Help?

Interested in joining or learning more about this trial?

(888) 828-2206

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

University of South Alabama Mitchell Cancer Institute

Mobile, AL

Open and Accepting

California

Kaiser Permanente Orange County Irvine Medical Center

Irvine, CA

Not Yet Accepting

Los Angeles Cancer Network (Los Angeles)

Los Angeles, CA

Not Yet Accepting

Los Angeles Cancer Network (Van Nuys)

Los Angeles, CA

Not Yet Accepting

Los Angeles Cancer Network (Pasadena)

Pasadena, CA

Not Yet Accepting

Georgia

Augusta University Medical Center

Augusta, GA

Not Yet Accepting

Massachusetts

Dana-Farber Cancer Institute

Boston, MA

Not Yet Accepting

New York

Montefiore Medical Center

Bronx, NY

Not Yet Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Not Yet Accepting

Ohio

OhioHealth Riverside Methodist Hospital

Columbus, OH

Not Yet Accepting

Texas

Houston Methodist Hospital

Houston, TX

Open and Accepting

Baylor Scott & White Hospital

Temple, TX

Not Yet Accepting

Washington

Northwest Medical Specialties (Gig Harbor)

Gig Harbor, WA

Open and Accepting

Interested in this trial?

Call us today 😀

We know how difficult and confusing this process can be. If you are interested in this clinical trial or have questions, you can call us at any time. You can also send us a direct message with questions.
(888) 828-2206

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You can explore trial locations from around the US and connect directly with a trial coordinator.
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Talk to your doctor

You can print an overview of this trial to take in to your next appointment. Your doctor can help you understand if this trial may be right for you.

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