A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) SUCCESSOR-2

What's the purpose of this trial?

The purpose of the study is to compare CC-92480 (BMS-986348) with carfilzomib and dexamethasone (480Kd) against carfilzomib and dexamethasone (Kd) in the treatment of relapsed or refractory multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  • Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following:
    • Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or
    • M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or,
    • For participants without measurable disease in sPEP or uPEP: serum free light chain levels > 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio .
  • Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, [with or without] hematopoietic stem cell transplant, (with or without) consolidation, and/or [with or without] maintenance therapy).
  • Participant must have received prior treatment with lenalidomide and an anti-CD38 monoclonal antibody.
  • Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy.
  • Participant must have documented disease progression during or after their last antimyeloma regimen.

Exclusion Criteria:

  • Participant who has had prior treatment with CC-92480 or carfilzomib.
  • Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment.

Additional protocol-defined criteria apply.

Additional Trial Information

Phase 3

Enrollment: 525 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.


University of South Alabama Mitchell Cancer Institute

Mobile, AL

Open and Accepting


Kaiser Permanente Orange County Irvine Medical Center

Irvine, CA

Not Yet Accepting

Los Angeles Cancer Network (Los Angeles)

Los Angeles, CA

Not Yet Accepting

Los Angeles Cancer Network (Van Nuys)

Los Angeles, CA

Not Yet Accepting

Los Angeles Cancer Network (Pasadena)

Pasadena, CA

Not Yet Accepting


Augusta University Medical Center

Augusta, GA

Not Yet Accepting


Dana-Farber Cancer Institute

Boston, MA

Not Yet Accepting

New York

Montefiore Medical Center

Bronx, NY

Not Yet Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Not Yet Accepting


OhioHealth Riverside Methodist Hospital

Columbus, OH

Not Yet Accepting


Houston Methodist Hospital

Houston, TX

Open and Accepting

Baylor Scott & White Hospital

Temple, TX

Not Yet Accepting


Northwest Medical Specialties (Gig Harbor)

Gig Harbor, WA

Open and Accepting
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