A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy (CARTITUDE-5) CARTITUDE-5

What's the purpose of this trial?

The purpose of this study is to compare the efficacy of Bortezomib, Lenalidomide and Dexamethasone (VRd) induction followed by a single administration of ciltacabtagene autoleucel (cilta-cel) versus VRd induction followed by Lenalidomide and Dexamethasone (Rd) maintenance in newly diagnosed multiple myeloma participants for whom ASCT is not planned as initial therapy in terms of Progression Free Survival (PFS).

This is an upcoming trial that has not yet started accepting patients.


What will happen during the trial?

Additional Trial Information

Phase 3

Enrollment: 650 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

California

Florida

AdventHealth (East Orlando)

Orlando, FL

Not Yet Accepting

Kentucky

Norton Cancer Institute St. Matthews Campus

Louisville, KY

Not Yet Accepting

Massachusetts

Massachusetts General Hospital

Boston, MA

Not Yet Accepting

Beth Israel Deaconess Medical Center

Boston, MA

Not Yet Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Not Yet Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Not Yet Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Not Yet Accepting

Levine Cancer Institute Atrium Health

Charlotte, NC

Not Yet Accepting

Pennsylvania

Thomas Jefferson University Hospital

Philadelphia, PA

Not Yet Accepting

University of Pittsburgh Medical Center (UPMC)

Pittsburgh, PA

Not Yet Accepting

Texas

Wisconsin

Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Not Yet Accepting
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