The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of CFT7455 administered orally in subjects with Relapsed/Refractory (r/r) Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM) administered once a day (QD) as a single agent and in combination with dexamethasone (in MM patients only).
This trial is currently open and accepting patients.
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.
Inclusion Criteria:
Have histologically or cytologically-confirmed NHL or MM that is r/r disease and must not be candidates for regimens known to provide clinical benefit
In Phase 2, only subjects with the following indications will be eligible for the appropriate expansion arm:
Subjects need to have adequate organ function defined as follows to include:
A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies:
Exclusion Criteria:
Have any of the following:
Impaired cardiac function or clinically significant cardiac disease, including any of the following:
Phase 1/2
Enrollment: 158 patients (estimated)
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December 12, 2023
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Denver, CO
St. Louis, MO
Nashville, TN
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