An open-label, multicenter, dose escalation study to evaluate the safety, tolerability and PK/pharmacodynamics of AO-176 in adults with relapsed/refractory multiple myeloma whose disease has progressed following at least 3 prior systemic lines of treatment and must have progressed on the final line of therapy received before being considered for this study. The study will be conducted in 2 phases; Phase 1 is an ascending-dose study of AO-176 monotherapy utilizing the classic 3+3 design, with enrollment of 3 patients per cohort and expansion of the cohort in the event of a dose-limiting toxicity (DLT). Following the dose escalation portion and determination of the monotherapy recommended phase 2 dose (RP2D), an ascending dose escalation study of AO-176 and dexamethasone combined with bortezomib will be evaluated utilizing the same 3+3 dose escalation design. Phase 2 will evaluate the clinical activity of AO-176 plus dexamethasone and bortezomib at the RP2D as determined in Phase 1 Part 2.
SparkCures ID | 1104 |
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Trial Phase | Phase 1/2 |
Enrollment | 102 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Key Inclusion Criteria:
Key Exclusion Criteria:
The following is a listing of trial locations that are open and accepting patients.
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Scottsdale, AZ
Jacksonville, FL
Rochester, MN
The following is a listing of trial locations that are not currently open and accepting patients.
SparkCures Verified Accurate, up-to-date information. Learn more
Stanford, CA
Boston, MA
Boston, MA
Seattle, WA
Scottsdale, AZ
Stanford, CA
Jacksonville, FL
Boston, MA
Boston, MA
Rochester, MN
Seattle, WA
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