High Dose Ascorbic Acid for Plasma Cell Disorders

Overview

This is a phase 1 study for patients with relapsed refractory multiple myeloma. Patients will receive a 15-gram test dose, and a maximum of 3 cycles, each composed of 4 doses of high-dose ascorbic acid (HDAA) and 2 doses of melphalan. This study will enroll 9 patients with relapsed refractory multiple myeloma. The starting dose of ascorbic acid will be 50 grams. Using a 3+3 dose escalation, the dose will potentially increase to 75 grams then 100 grams.

SparkCures ID 992
Trial Phase Phase 1
Enrollment 9 Patients
Treatments
Tags
Trial Sponsors
  • University of Iowa
NCT Identifier

NCT03602235

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Inclusion Criteria:

  1. Subject has provided informed consent.
  2. Patients who have been previously treated with 3 or more lines of therapy, i.e. proteasome inhibitors, immuno-modulatory agents such as lenalidomide and monoclonal antibodies such as daratumumab, and have progressed within past 6 months. Participants with previous failed autologous transplant and progressed within 6 months after autologous transplant. Note: induction with or without hematopoietic stem cell transplant and with or without maintenance therapy is considered a single regimen.
  3. Patients have failed treatment with, are intolerant to or are not candidates for available therapies that are known to confer clinical benefit to patients with relapsed and refractory MM.
  4. Subjects must have measurable disease (as determined by the central lab), including at least one of the criteria below:
    • M-protein quantities >/= 0.5 g/dl by SPEP or
    • >/= 200 mg/24 hour urine collection by UPEP or
    • serum free light chain levels > 100 mg/L (milligrams/liter involved light chain) and an abnormal kappa/lambda (κ/λ) ratio in patients without detectable serum or urine m-protein or
    • For patients with immunoglobulin class A (IgA) myeloma whose disease can only be reliably measured by quantitative immunoglobulin measurement, a serum IgA level >/= 500 mg/dL.

    Non-secretory participants are eligible provided the participant has > 20% bone marrow plasmacytosis OR multiple (>/= 3) plasmacytomas or lesions on MRI at the time of diagnosis or study enrollment, OR the presence of lesions (>/= 3) on PET/CT scan.

  5. Adequate organ function:
    • Absolute neutrophil count (ANC) >/= 1.0 x 109/L without growth factor support for 7 days (14 days if pegfilgastrim)
    • Platelets (plt) >/= 50 x 109/L without transfusion for 7 days. However, patient can be enrolled if the ANC and platelets are low due to disease.
    • Potassium within normal limits or correctable with supplements
    • Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT)
    • Serum bilirubin
    • Estimated serum creatinine clearance of >/= 45 mL/min using the Cockcroft-Gault equation or directly calculated from the 24-hour urine collection method
    • International normalized ratio (INR) < 1.5 x ULN and partial thromboplastin time (PTT) < 1.5 x ULN
    • Ejection fraction by ECHO or MUGA of >/= 40% performed.
    • Participants must have adequate pulmonary function studies (PFTs), > 50% of predicted on mechanical aspects (FEV1, FVC) and diffusion capacity ( DLCO) > 50% of predicted (adjusted for hemoglobin). If the participant is unable to complete PFTs due to disease-related pain or other circumstances that make it difficult to reliably perform PFTs, documentation of pulmonary function adequate for transplant will occur via a CT scan without evidence of major pulmonary disease, and arterial blood gas results.
  6. Participants must have a performance status of 0-2 based on ECOG criteria. Participants with poor performance status (3-4) based solely on bone pain will be eligible, provided there is documentation to verify this.
  7. Negative serum or urine pregnancy test (sensitivity of at least 25 mIU/mL) at screening.

Exclusion Criteria:

  1. Prior allogeneic transplant.
  2. Known hypersensitivity or allergy to ascorbic acid or melphalan.
  3. Participants must not have a concurrent malignancy unless it can be adequately treated by non-chemotherapeutic intervention. Participants may have a history of prior malignancy, provided that he/she has not had any chemotherapy within 365 days of study entry AND that life expectancy exceeds 5 years at the time of study entry.
  4. Participants must not have life-threatening comorbidities.
  5. History or evidence of myeloma associated with immunodeficiency states (e.g.: Hereditary immune deficiency, HIV, organ transplant or leukemia).
  6. Known human immunodeficiency virus (HIV) disease (requires negative test for clinically suspected HIV infection).
  7. Evidence of CNS myeloma.
  8. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, recent (within 6 months) myocardial infarction, uncontrolled or symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled hypertension on appropriate therapy or psychiatric illness/social situations that would limit compliance with study requirements.
  9. Concurrent use of Coumadin (warfarin)
  10. Patients with G6PD deficiency
  11. Patients with a history of oxalate renal stones or a known history of multiple renal stones
  12. Diabetic patients who rely on a glucometer to dose insulin as ascorbate can interfere with glucometer readings

US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

SparkCures Verified Accurate, up-to-date information. Learn more

Iowa

SparkCures Verified Accurate, up-to-date information. Learn more

Resources

There are no resources, links or videos to display for this clinical trial.

Interested in this trial?
  • Call us today 😀 keyboard_arrow_right

    We know how difficult and confusing this process can be. If you are interested in this clinical trial or have questions, you can call us at any time. You can also send us a direct message with questions.

    (888) 828-2206
  • If you are interested in keeping an eye on this trial, you can add it to your list of favorite trials. We'll send you alerts when this trial is updated.

  • Talk to your doctor keyboard_arrow_right

    You can print an overview of this trial to take in to your next appointment. Your doctor can help you understand if this trial may be right for you.

Still need help? Send us a message