Personalized Vaccine in Treating Patients With Smoldering Multiple Myeloma

What's the purpose of this trial?

This early phase I trial studies the side effects of personalized vaccine in treating patients with smoldering multiple myeloma. Vaccines made from a person's blood and bone marrow may help the body build an effective immune response to kill cancer cells.

PRIMARY OBJECTIVES:

  1. To demonstrate that developing a custom vaccine for smoldering multiple myeloma (SMM) is feasible.
  2. To show that a custom peptide-based vaccine in smoldering multiple myeloma is safe.

OUTLINE:

Patients undergo collection of blood and bone marrow for making the vaccine. Patients then receive personalized vaccine SC on days 1 and 15 of cycles 1-2 and on day 1 of cycles 3-6. Patients also receive lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, participants are followed up at 3 and 12 months.

This trial is currently open and accepting patients.

What will happen during the trial?

Additional Trial Information

Phase 1

Enrollment: 30 patients (estimated)

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Trial Locations

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Texas

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting
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