This early phase I trial studies the side effects of personalized vaccine in treating patients with smoldering multiple myeloma. Vaccines made from a person's blood and bone marrow may help the body build an effective immune response to kill cancer cells.
PRIMARY OBJECTIVES:
OUTLINE:
Patients undergo collection of blood and bone marrow for making the vaccine. Patients then receive personalized vaccine SC on days 1 and 15 of cycles 1-2 and on day 1 of cycles 3-6. Patients also receive lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, participants are followed up at 3 and 12 months.
This trial is currently open and accepting patients.
Phase 1
Enrollment: 30 patients (estimated)
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October 28, 2021
Many approaches are attempting to prevent smoldering myeloma from progressing to active myeloma. One such approach is a personalized vaccine being developed at MD Anderson Cancer Center.
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