Study of ISB 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma

Overview

The purpose of this study is to determine the safety profile, maximum tolerable dose (MTD) and cohort expansion of single-agent ISB 1342 in subjects with multiple myeloma who have received prior therapies.

SparkCures ID 919
Trial Phase Phase 1/2
Enrollment 125 Patients
Treatments
Tags
Trial Sponsors
  • Ichnos Sciences SA
Trial Collaborators
  • Glenmark Pharmaceuticals S.A.
NCT Identifier

NCT03309111

Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Inclusion Criteria:

  • Males or females with multiple myeloma who have exhausted available standard therapies.
  • Measurable disease, defined as any quantifiable monoclonal protein value
  • ECOG performance-status score of 2 or less
  • Life expectancy of at least 3 months
  • Recovered from any previous surgery and no history of major surgery within the last 28 days prior to start of study drug

Exclusion Criteria:

  • Any condition that, in the opinion of the Investigator, would interfere with evaluation of the study drug or interpretation of subject safety or study results.
  • Active infectious disease considered by the Investigator to be incompatible with the protocol.
  • Evidence of clinically significant cardiovascular and respiratory conditions
  • Anti-myeloma treatment within 2 weeks
  • Use of any investigational drug within the past 4 weeks

US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

Arkansas
Colorado
Maryland
New Jersey
Verified John Theurer Cancer Center Hackensack Meridian Health

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New York
Verified Memorial Sloan Kettering Cancer Center

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Tennessee

Resources

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