MMRF Molecular Profiling Protocol

What's the purpose of this trial?

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  1. Patients must have a diagnosis of multiple myeloma or related malignancy
  2. Patients are undergoing standard of care bone marrow aspirates
  3. Patients (male or female) from any race or ethnicity must be at least 18 years of age at the time of registration.
  4. Procedure-specific signed informed consent form prior to initiation of any study-related procedures.

Exclusion Criteria:

  1. It is the enrolling study physician's discretion to decide if a patient is not fit enough to undergo a bone marrow aspirate.
  2. Patients who are incarcerated are not eligible to participate.
  3. Women who are pregnant
  4. Patients who have had another malignancy within the last five (5) years (except for basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a possibility to contaminate the bone marrow aspirate.

Additional Trial Information

Enrollment: 500 patients (estimated)

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Trial Locations

All Trial Locations

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City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting


Winship Cancer Institute of Emory University

Atlanta, GA

Open and Accepting

New Jersey

John Theurer Cancer Center Hackensack Meridian Health

Hackensack, NJ

Open and Accepting



Baylor Charles A. Sammons Cancer Center Baylor Scott & White Health

Dallas, TX

Open and Accepting
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