The following criteria is provided for health care professionals.

Inclusion Criteria:

• Participants with end-stage renal failure due to or in association with Durie Salmon Stage II or III multiple myeloma) or other hematologic disorder for which hematopoietic stem cell transplantation is appropriate. This includes, but is not limited to: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, multiple myeloma (MM), myelodysplastic syndrome (MDS), AL amyloidosis, Diamond Blackfan Anemia, myelofibrosis or other myeloproliferative disease, sickle cell anemia, and thalassemia.
• Patients with myeloma must be in a very good partial remission or complete remission at the time of transplant. Patients with other hematologic malignancies must have treatment responsive disease at the time of transplant.
• Males or females 18 - 65 years of age.
• Participants must have an HLA-matched or one of six HLA antigen-mismatched related donor, with high resolution molecular class I and II allele typing.
• Men and women of reproductive potential must agree to use a reliable method of birth control during the treatment, and women should do so for a period of 2 years following the transplant.
• Participants should be on dialysis or have a creatinine clearance <20 ml/min.
• Life expectancy >6 months.
• Patients with a history of other malignancies excluding basal cell carcinoma of the skin and carcinoma in situ of the cervix with a disease-free survival interval of >2 years. Patients with the following malignancies must demonstrate a 5 year disease-free survival:
  • Breast cancer with positive nodes
  • Malignant melanoma (other than in situ)
  • Colorectal cancer (other than Dukes Stage A or B1)
• Patients with multiple myeloma must have received previous treatment with a bortezomib-based regimen.
• Patients with a history of malignant melanoma must be reviewed by an independent oncologist prior to enrollment.
• Recipient ability to understand and provide informed consent

Exclusion Criteria:

• Evidence of active infection as defined by: a) clinical syndrome consistent with viral or bacterial infection (e.g., influenza, upper respiratory tract infection, UTI) or b) fever with a clinical site of infection identified, or c) microbiologically documented infection, including, but not limited to, bacteremia or septicemia.
• Participation in other investigational drug use at the time of enrollment.
• Contraindication to therapy with any one of the proposed agents (e.g., history of allergy to horse serum in ATG).
• Serologic positivity to HIV or hepatitis C virus.
• Women of childbearing age in whom adequate contraception cannot be maintained.
• Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT) > 3 x normal or bilirubin > 1.5 x normal (unless due to Gilbert's syndrome).
• Pregnancy or uncontrolled serious medical illness not related to underlying myeloma.
• Cardiac ejection fraction < 40% by echocardiogram.
• Forced expiratory volume at one second (FEV1) < 50% predicted or corrected diffusing capacity carbon monoxide (DLCO) < 50% predicted.
• Blood group A,B,O incompatibility in the host-vs-graft direction.