Phase 3 Clinical Trial Evaluating the Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants with Relapsed or Refractory Multiple Myeloma ALUMMINATE RRMM
Verified

What's the purpose of this trial?

The goal of this clinical trial is to learn more about the safety and efficacy of an investigational drug called Alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma. 

This is an upcoming trial that has not yet started accepting patients.

What will happen during the trial?

This trial is seeking approximately 466 patients who will be randomly assigned into one of two different groups (or arms). This trial is open-label, which means that both researchers and participants will know which arms they are placed in, and which medications and doses they will be receiving. Study participants may continue to receive study medications unless their myeloma gets worse, or they experience serious side effects. 

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have measurable disease as defined by the trial criteria.
  • have received 1-3 prior lines of therapy.
  • have previously received treatment with lenalidomide and an anti-CD38 monoclonal antibody.
  • do not have central nervous system involvement of your myeloma.
  • have not previously received BCMA targeted therapy.
  • have not previously received an allogeneic (donor) stem cell transplant, and have not received an autologous stem cell transplant within three months before joining this study.

Additional Trial Information

Phase 3

Enrollment: 466 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

Birmingham, AL

Not Yet Accepting

Infirmary Cancer Care

Mobile, AL

Not Yet Accepting

Alaska

Alaska Oncology and Hematology LLC

Anchorage, AK

Not Yet Accepting

Arizona

Banner MD Anderson Cancer Center at Banner Gateway Medical Center

Gilbert, AZ

Not Yet Accepting

Arizona Clinical Research Center, Inc.

Tucson, AZ

Not Yet Accepting

Arkansas

University of Arkansas for Medical Sciences (UAMS)

Little Rock, AR

Not Yet Accepting

California

Clovis Community Cancer Institute

Clovis, CA

Not Yet Accepting

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Not Yet Accepting

Moores Cancer Center University of California UC San Diego Health

La Jolla, CA

Not Yet Accepting

University of California Irvine Medical Center

Orange, CA

Not Yet Accepting

University of California Davis Comprehensive Cancer Center

Sacramento, CA

Not Yet Accepting

UCSF Medical Center (Parnassus)

San Francisco, CA

Not Yet Accepting

UCLA Medical Center, Santa Monica UCLA Health

Santa Monica, CA

Not Yet Accepting

Stanford University Cancer Institute (Palo Alto)

Stanford, CA

Not Yet Accepting

Connecticut

Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven

New Haven, CT

Not Yet Accepting

Whittingham Cancer Center at Norwalk Hospital Nuvance Health

Norwalk, CT

Not Yet Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Not Yet Accepting

Baptist MD Anderson

Jacksonville, FL

Not Yet Accepting

Memorial Cancer Institute Memorial Hospital West

Pembroke Pines, FL

Not Yet Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Not Yet Accepting

University Cancer and Blood Center

Athens, GA

Not Yet Accepting

Northside Hospital (Atlanta)

Atlanta, GA

Not Yet Accepting

Augusta University Medical Center

Augusta, GA

Not Yet Accepting

Illinois

University of Illinois at Chicago

Chicago, IL

Not Yet Accepting

Advocate Lutheran General Hospital

Park Ridge, IL

Not Yet Accepting

Indiana

Franciscan Health Cancer Center Indianapolis

Indianapolis, IN

Not Yet Accepting

Iowa

Holden Comprehensive Cancer Center - University of Iowa University of Iowa Hospitals and Clinics

Iowa City, IA

Not Yet Accepting

McFarland Clinic PC

Ames, IA

Not Yet Accepting

Kentucky

Norton Cancer Institute (St. Matthews) St. Matthews Campus

Louisville, KY

Not Yet Accepting

Louisiana

Our Lady of the Lake Regional Medical Center

Baton Rouge, LA

Not Yet Accepting

Ochsner Medical Center

Jefferson, LA

Not Yet Accepting

Maryland

Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Not Yet Accepting

Ascension Saint Agnes Hospital Saint Agnes Healthcare

Baltimore, MD

Not Yet Accepting

American Oncology Partners of Maryland (Bethesda) The Center for Cancer & Blood Disorders - Bethesda

Bethesda, MD

Not Yet Accepting

Massachusetts

University of Massachusetts Medical School

Worcester, MA

Not Yet Accepting

Michigan

Barbara Ann Karmanos Cancer Institute Wayne State University

Detroit, MI

Not Yet Accepting

Ascension Providence Hospital (Southfield) St. John Newland Medical Associates

Southfield, MI

Not Yet Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Not Yet Accepting

Missouri

Saint Luke's Hospital of Kansas City

Kansas City, MO

Not Yet Accepting

Mercy Hospital St. Louis David C. Pratt Cancer Center

St. Louis, MO

Not Yet Accepting

Nebraska

Methodist Hospital Nebraska Methodist Health System

Omaha, NE

Not Yet Accepting

New Jersey

John Theurer Cancer Center at Hackensack University Medical Center  Hackensack Meridian Health

Hackensack, NJ

Not Yet Accepting

Summit Health

Florham Park, NJ

Not Yet Accepting

Hackensack Meridian Jersey Shore University Medical Center

Neptune City, NJ

Not Yet Accepting

Overlook Hospital

Summit, NJ

Not Yet Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Not Yet Accepting

Roswell Park Cancer Institute

Buffalo, NY

Not Yet Accepting

Broome Oncology

Johnson City, NY

Not Yet Accepting

Weill Cornell

New York, NY

Not Yet Accepting

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Not Yet Accepting

Herbert Irving Comprehensive Cancer Center (Columbia University) Columbia University Medical Center

New York, NY

Not Yet Accepting

University of Rochester Medical Center Wilmot Cancer Center Strong Memorial Hospital

Rochester, NY

Not Yet Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Not Yet Accepting

Wake Forest Baptist - Comprehensive Cancer Center Atrium Health

Winston-Salem, NC

Not Yet Accepting

Novant Health Presbyterian Medical Center Novant Health

Charlotte, NC

Not Yet Accepting

Ohio

University of Cincinnati College of Medicine George L. Strike Bone Marrow Transplant Program

Cincinnati, OH

Not Yet Accepting

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Not Yet Accepting

MetroHealth Medical Center

Cleveland, OH

Not Yet Accepting

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Not Yet Accepting

University Hospitals Seidman Cancer Center Seidman Cancer Center at UH Case Medical

Cleveland, OH

Not Yet Accepting

Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute

Columbus, OH

Not Yet Accepting

Oregon

Oregon Health and Science University OHSU Knight Cancer Institute

Portland, OR

Not Yet Accepting

Pennsylvania

Thomas Jefferson University Hospital

Philadelphia, PA

Not Yet Accepting

Rhode Island

Lifespan Cancer Institute The Miriam Hospital

Providence, RI

Not Yet Accepting

Texas

Baylor Charles A. Sammons Cancer Center Baylor Scott & White Health

Dallas, TX

Not Yet Accepting

Joe Arrington Cancer Research and Treatment Center Covenant Health

Lubbock, TX

Not Yet Accepting

Virginia

Blue Ridge Cancer Care (Blacksburg)

Blacksburg, VA

Not Yet Accepting

Washington

Northwest Medical Specialties

Federal Way, WA

Not Yet Accepting

VA Puget Sound Health Care System

Seattle, WA

Not Yet Accepting

Fred Hutchinson Cancer Research Center University of Washington Cancer Consortium / SCCA

Seattle, WA

Not Yet Accepting

Confluence Health - Wenatchee Valley Hospital & Clinics

Wenatchee, WA

Not Yet Accepting

Wisconsin

University of Wisconsin - Carbone Cancer Center University of Wisconsin Health

Madison, WI

Not Yet Accepting

Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Not Yet Accepting
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