A Phase 3, Randomized, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) - ALUMMINATE RRMM ALUMMINATE
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What's the purpose of this trial?

The purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (RRMM).

This is an upcoming trial that has not yet started accepting patients.


What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Participant is willing and able to adhere to the study visit schedule and other protocol requirements including bone marrow aspirations and/or biopsies and hospitalization during the first cycle
* Documented diagnosis of multiple myeloma (MM), and must:

i) Received at least 1 but not more than 3 prior lines of anti-myeloma therapy ii) Received prior treatment with lenalidomide and an anti-CD38 monoclonal antibody (for at least 2 consecutive cycles) iii) Achieved minimal response (MR) or better to at least 1 prior anti-myeloma therapy iv) Documented PD during or after their last anti-myeloma therapy or failure to achieve response
* Must have measurable disease (as determined by central laboratory)
* Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2 at the time of the screening

Exclusion Criteria:

* Active, uncontrolled, or suspected infection
* Known current, or history of, central nervous system involvement of multiple myeloma
* History or presence of clinically relevant CNS pathology
* Received prior BCMA-targeted TCE or BCMA-targeted CAR-T therapy
* Previously received allogeneic stem cell transplantation at any time or received autologous stem cell transplantation within 3 months of initiating study intervention

Other protocol-defined inclusion/exclusion criteria apply

Additional Trial Information

Phase 3

Enrollment: 466 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

University of Alabama at Birmingham O'Neal Comprehensive Cancer Center at UAB

Birmingham, AL

Not Yet Accepting

Infirmary Cancer Care

Mobile, AL

Not Yet Accepting

Alaska

Alaska Oncology and Hematology LLC

Anchorage, AK

Not Yet Accepting

Arizona

Banner MD Anderson Cancer Center at Banner Gateway Medical Center

Gilbert, AZ

Not Yet Accepting

Arizona Clinical Research Center, Inc.

Tucson, AZ

Not Yet Accepting

Arkansas

University of Arkansas for Medical Sciences (UAMS)

Little Rock, AR

Not Yet Accepting

California

Clovis Community Cancer Institute

Clovis, CA

Not Yet Accepting

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Not Yet Accepting

Moores Cancer Center University of California UC San Diego Health

La Jolla, CA

Not Yet Accepting

University of California Irvine Medical Center

Orange, CA

Not Yet Accepting

University of California Davis Comprehensive Cancer Center

Sacramento, CA

Not Yet Accepting

UCSF Medical Center (Parnassus)

San Francisco, CA

Not Yet Accepting

UCLA Medical Center, Santa Monica UCLA Health

Santa Monica, CA

Not Yet Accepting

Stanford University Cancer Institute (Palo Alto)

Stanford, CA

Not Yet Accepting

Connecticut

Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven

New Haven, CT

Not Yet Accepting

Whittingham Cancer Center at Norwalk Hospital Nuvance Health

Norwalk, CT

Not Yet Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Not Yet Accepting

Baptist MD Anderson

Jacksonville, FL

Not Yet Accepting

Memorial Hospital West Memorial Healthcare System

Pembroke Pines, FL

Not Yet Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Not Yet Accepting

University Cancer and Blood Center

Athens, GA

Not Yet Accepting

Northside Hospital (Atlanta)

Atlanta, GA

Not Yet Accepting

Augusta University Medical Center

Augusta, GA

Not Yet Accepting

Illinois

University of Illinois at Chicago

Chicago, IL

Not Yet Accepting

Advocate Lutheran General Hospital

Park Ridge, IL

Not Yet Accepting

Indiana

Franciscan Health Cancer Center Indianapolis

Indianapolis, IN

Not Yet Accepting

Iowa

McFarland Clinic PC

Ames, IA

Not Yet Accepting

Kentucky

Norton Cancer Institute (St. Matthews) St. Matthews Campus

Louisville, KY

Not Yet Accepting

Louisiana

Our Lady of the Lake Regional Medical Center

Baton Rouge, LA

Not Yet Accepting

Ochsner Medical Center

Jefferson, LA

Not Yet Accepting

Maryland

Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medicine

Baltimore, MD

Not Yet Accepting

Ascension Saint Agnes Hospital Saint Agnes Healthcare

Baltimore, MD

Not Yet Accepting

Massachusetts

University of Massachusetts Medical School

Worcester, MA

Not Yet Accepting

Michigan

Barbara Ann Karmanos Cancer Institute Wayne State University

Detroit, MI

Not Yet Accepting

Ascension Providence Hospital (Southfield)

Southfield, MI

Not Yet Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Not Yet Accepting

Missouri

Saint Luke's Hospital of Kansas City

Kansas City, MO

Not Yet Accepting

Mercy Hospital St. Louis David C. Pratt Cancer Center

St. Louis, MO

Not Yet Accepting

Nebraska

Methodist Hospital Nebraska Methodist Health System

Omaha, NE

Not Yet Accepting

New Jersey

Summit Health

Florham Park, NJ

Not Yet Accepting

Hackensack Meridian Jersey Shore University Medical Center

Neptune City, NJ

Not Yet Accepting

Overlook Hospital

Summit, NJ

Not Yet Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Not Yet Accepting

Roswell Park Cancer Institute

Buffalo, NY

Not Yet Accepting

Broome Oncology

Johnson City, NY

Not Yet Accepting

Weill Cornell

New York, NY

Not Yet Accepting

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Not Yet Accepting

University of Rochester ~ Wilmot Cancer Institute

Rochester, NY

Not Yet Accepting

University of Rochester Medical Center James P. Wilmot Cancer Center

Rochester, NY

Not Yet Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Not Yet Accepting

Wake Forest Baptist - Comprehensive Cancer Center Atrium Health

Winston-Salem, NC

Not Yet Accepting

Novant Health Presbyterian Medical Center Novant Health

Charlotte, NC

Not Yet Accepting

Ohio

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Not Yet Accepting

Cleveland Clinic - Taussig Cancer Center Taussig Cancer Institute

Cleveland, OH

Not Yet Accepting

MetroHealth Medical Center

Cleveland, OH

Not Yet Accepting

Oregon

Oregon Health and Science University OHSU Knight Cancer Institute

Portland, OR

Not Yet Accepting

Pennsylvania

Thomas Jefferson University Hospital

Philadelphia, PA

Not Yet Accepting

Rhode Island

Lifespan Cancer Institute The Miriam Hospital

Providence, RI

Not Yet Accepting

Texas

Baylor Charles A. Sammons Cancer Center Baylor Scott & White Health

Dallas, TX

Not Yet Accepting

Joe Arrington Cancer Research and Treatment Center CovenantHealth

Lubbock, TX

Not Yet Accepting

Virginia

Blue Ridge Cancer Care (Blacksburg)

Blacksburg, VA

Not Yet Accepting

Washington

Northwest Medical Specialties

Federal Way, WA

Not Yet Accepting

VA Puget Sound Health Care System

Seattle, WA

Not Yet Accepting

Confluence Health - Wenatchee Valley Hospital & Clinics

Wenatchee, WA

Not Yet Accepting

Wisconsin

Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Not Yet Accepting
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