A Comparative Clinical Study to Determine the Optimal Initial Therapy for Multiple Myeloma PRAGMMATIC

What's the purpose of this trial?

This study evaluates the outcomes of patients undergoing initial therapy for multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

PRIMARY OBJECTIVE:

I. Compare the overall survival between bortezomib, lenalidomide and dexamethasone (VRd), daratumumab, lenalidomide and dexamethasone (DRd) and daratumumab, bortezomib, lenalidomide and dexamethasone (DVRd) used as initial therapy for patients with newly diagnosed MM.

OUTLINE: This is an observational study.

Patients have their medical records reviewed on study.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Previously untreated active multiple myeloma starting a new treatment for the disease with one of the three established treatment regimens: VRd (bortezomib, lenalidomide, dexamethasone), DRd (daratumumab lenalidomide dexamethasone), or DVRd (daratumumab, bortezomib, lenalidomide, and dexamethasone)
* No prior treatment for myeloma
* Not receiving concurrent treatment for another active malignancy
* No more than 3 months from start of treatment

Additional Trial Information

Observational Trial

Enrollment: 2,370 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Arizona

Mayo Clinic (Arizona)

Phoenix, AZ

Open and Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Open and Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

Wisconsin

Mayo Clinic Health System (La Crosse)

La Crosse, WI

Not Yet Accepting
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