The following criteria is provided for health care professionals.

Inclusion Criteria:

* Age ≥18 years
* ECOG performance status ≤2
* Confirmed multiple myeloma diagnosis
* Hair covering ≥75% of scalp on physical exam at screening visit
* Planning to undergo SOC high-dose chemotherapy with melphalan (dose to be used = 140 - 200 mg/m2 (with rounding per CSMC guidelines)) followed by an autologous peripheral blood stem cell transplant.
* Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.

Exclusion Criteria:

* Prior or current use of any scalp cooling treatment
* Hair covering \< 75% of the scalp on physical exam at screening visit.
* Medical History and Concurrent Diseases: Reynaud's disease, Cold sensitivity, Cold agglutinin disease, Cryoglobulinemia, Cryofibrinogenemia
* Current spinal or neck injury that may interfere with the subject's participation for the full duration of the study, in the opinion of the treating investigator
* Skin conditions such as psoriasis, eczema, malignancy, or other condition on the scalp that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
* Current use of oxaliplatin
* Current use of any other investigational agents
* Contraindication to melphalan