Exploratory Study of Fluoroquinolone Resistance for Patients Undergoing Autologous Hematopoietic Stem Cell (HSC) Transplantation in the Treatment of Multiple Myeloma FRE

What's the purpose of this trial?

This is an exploratory study to determine the prevalence of fluoroquinolone resistance in patients receiving dose-intense melphalan with autologous peripheral blood stem cell (PBSC) transplantation in the treatment of multiple myeloma (MM). These data may be used in subsequent studies exploring the use of prophylaxis in this patient population.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Subjects \>18 yrs of age.
* Diagnosis of multiple myeloma undergoing (first or subsequent) autologous PBSC transplantation.
* Transplant conditioning with melphalan 200 mg/m2.
* PBSC cell dose of \>2x10e6 CD34+ cells/kg.
* Able to receive fluoroquinolone prophylaxis.
* Subjects must give consent for enrollment into this study.

Exclusion Criteria:

* Unwillingness to provide informed consent.
* Enrollment into a treatment protocol prescribing antibiotic prophylaxis.
* A diagnosis other than multiple myeloma.
* Receiving a conditioning regimen other than melphalan 200 mg/m2.
* Known light-chain amyloid deposition in any organ.

Additional Trial Information

Enrollment: 144 patients (estimated)

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Trial Locations

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New Jersey

John Theurer Cancer Center Hackensack Meridian Health

Hackensack, NJ

Open and Accepting

Washington, D.C.

Georgetown Lombardi Comprehensive Cancer Center Georgetown University

Washington, DC

Open and Accepting
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