Inclusion Criteria:

* Documented MM per International Myeloma Working Group diagnostic criteria (evidence of myeloma defining event attributed to underlying plasma cell disorder): i. Clonal plasma cells in the bone marrow ≥ 10% or presence of a biopsy proven plasmacytoma; and ii. Any one or more of the following myeloma defining events:
* Evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder:

1. Hypercalcemia: serum calcium \>0.25 mmol/L (\>1 mg/dL) higher than the upper limit of normal or \>2.75 mmol/L (\>11 mg/dL)
2. Renal insufficiency: creatinine clearance \< 40 mL/min or serum creatinine 177µmol/L (\>2 mg/dL)
3. Anemia: hemoglobin \> 2 g/dL below the lower limit of normal, or a hemoglobin value \<10 g/dL
4. Bone lesions: one or more osteolytic lesions on skeletal radiography, CT, or PET/CT
* Clonal bone marrow plasma cell percentage ≥ 60%; or
* Involved: uninvolved serum free light chain (FLC) ratio ≥ 100 (involved FLC level be ≥ 10 mg/dL; or
* \>1 focal lesion on MRI studies (at least 5 mm in size)
* Presence of lytic bone lesion(s) due to MM based on radiographic evidence with at least one measurable lesion (≥0.5 cm in its largest diameter by computerized tomography \[CT\])
* Postmenopausal female, defined as last menstrual cycle at least 12 months prior to study enrollment
* Must have one of the following:

* osteoporosis on dual X-ray absorptiometry (DXA) scan; or
* fragility fracture of the spine or hip; or
* morphometric spine fracture; or
* osteopenia with elevated risk of fracture (calculated by the FRAX online calculator)
* Within 12 months prior to study entry, ≤ 4 doses of prior intravenous bisphosphonate with the last dose ≥ 3 months prior to study entry.
* Prior oral bisphosphonates are allowed if the last dose was ≥ 3 months prior to study entry.
* Signed informed consent form(s). Individuals with impaired decision-making capacity may enroll if legally authorized representatives consent on behalf of individuals with impaired decision-making capacity.
* Ability to comply with all study-related procedures in the investigator's judgment
* 18 years of age or older

Exclusion Criteria:

* Assigned male at birth
* Received denosumab within 12 months prior to study entry
* Received teriparatide or other PTH analog use within 12 months prior to study entry
* Receiving concurrent antiresorptive therapy
* History of cardiovascular event (myocardial infarction and/or stroke) within the past 12 months of study entry
* History of non-healed dental or oral surgery
* History of osteonecrosis of the jaw
* 25 (OH) vitamin D levels \< 20 ng/mL. Vitamin D repletion will be permitted and subjects may be rescreened once 25 (OH) vitamin D level ≥ 20 ng/mL.
* Current hyper- or hypocalcemia, defined as albumin-adjusted serum calcium outside the normal range per institutional standard (\<8.5 or \>10.5 mg/dL).