Screening to Improve Survival in AL Amyloidosis

What's the purpose of this trial?

The purpose of this study is to see whether certain genes may be linked with the development of AL amyloidosis in subjects 60 years of age or older with the blood disorders SMM and MGUS. A limited repertoire of immunoglobulin (Ig) variable region genes have been associated with AL amyloidosis. The clonal plasma cells of subjects with SMM and MGUS may express one of these Ig variable region genes indicating a risk of progression to AL amyloidosis and potentially enabling early diagnosis. We hope this study will help us begin to understand whether Ig variable region gene identification can be a useful tool for assessing a subject's risk of progression to AL amyloidosis.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  • Patients 60 years of age and older diagnosed with λ LC MGUS or λ LC SMM with dFLC greater than 23 mg/L and κ::λ free LC ratio below normal

Exclusion Criteria:

  • Patients with κ LC MGUS or κ LC SMM or amyloid in the bone marrow or in other biopsies will not be included.

Additional Trial Information

Observational Trial

Enrollment: 50 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

California

UCSF Helen Diller Comprehensive Cancer Center University of California San Francisco

San Francisco, CA

Open and Accepting

Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, CA

Open and Accepting

Florida

Sylvester Comprehensive Cancer Center University of Miami Health System

Miami, FL

Not Yet Accepting

Massachusetts

Tufts Medical Center Cancer Center

Boston, MA

Open and Accepting

New York

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center

New York, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Open and Accepting
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