What's the purpose of this trial?

This is a prospective, multicenter, observational study of adult patients with a diagnosis of acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), or non-Hodgkin lymphoma (NHL). This study will enroll up to 528 patients in up to 50 sites in the United States and collect data with regard to use of the clonoSEQ MRD assay in the management of lymphoid malignancies.

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  1. Patients must be able to provide written informed consent
  2. A decision has been made by the treating provider to use the clonoSEQ Assay as part of routine clinical care
  3. Age ≥ 18 years;
  4. Documented hematologic malignancy (any of the below):
    1. MM
    2. ALL (B and T-cell subtypes)
    3. B-cell NHL (all sub types)
    4. CLL
    5. Other lymphoid malignancies (upon review and approval by study chair)

Exclusion Criteria:

Patients must not meet any of the following criteria in order to be enrolled into the study:

  1. Concurrent enrollment in a clinical trial where treatment decisions and patterns are dictated per protocol
  2. A decision has been made by the treating provider to not use the clonoSEQ Assay as part of routine clinical care

Additional Trial Information

Observational Trial

Enrollment: 528 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.


Stanford Cancer Institute (Palo Alto)

Stanford, CA

Open and Accepting


University of Colorado Cancer Center Anschutz Cancer Pavilion

Aurora, CO

Recruitment on Hold


Holy Cross Hospital Holy Cross Health, A Member of Trinity Health

Fort Lauderdale, FL

Open and Accepting


Hematology Oncology Clinic

Baton Rouge, LA

Not Yet Accepting



Alvin J. Siteman Cancer Center Washington University Medical Campus

St. Louis, MO

Open and Accepting

North Carolina

Novant Health Presbyterian Medical Center Novant Health

Charlotte, NC

Open and Accepting


Oregon Health and Science University OHSU Knight Cancer Institute

Portland, OR

Open and Accepting


Abramson Cancer Center University of Pennsylvania

Philadelphia, PA

Open and Accepting

South Carolina

Bon Secours St. Francis Hospital (Downtown)

Greenville, SC

Open and Accepting


Northwest Medical Specialties (Puyallup)

Puyallup, WA

Open and Accepting

Swedish - Cherry Hill Campus Cherry Hill Campus

Seattle, WA

Open and Accepting

Washington, D.C.

MedStar Georgetown University Hospital

Washington, DC

Open and Accepting
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