Mass Accumulation Rate (MAR) as a Predictive Biomarker for Treatment Selection in Multiple Myeloma

What's the purpose of this trial?

The goal of this trial is to see whether a test based on a new technology which assesses tumor cell mass accumulation rate (MAR) can help to predict how patients with relapsed/refractory disease will respond to multiple myeloma treatments.

This trial is currently open and accepting patients.

What will happen during the trial?

Researchers are asking patients who participate in this clinical trial to provide an approximately 10mL (2 teaspoons) bone marrow sample. This sample will be collected at a time when a bone marrow biopsy is already being performed as part of your standard of care treatment and will not require an additional procedure. This study has two groups, also called cohorts. Each cohort will provide the same volume of a one-time bone marrow sample.

Researchers are also requesting access to your medical information and myeloma treatment history. This data will be de-identified, and securely stored.

If you agree to take part in this study, there will be no direct medical benefit or additional costs to you.

You and your physician will not be informed of the results of the tests on your tumor cells at the time your physician is deciding on your treatment as the accuracy of this test is not yet proven. Proving the value of this this test is the purpose of this study. The testingprocedure is not a treatment. There is no benefit to participating in this part of the study except for the satisfaction of contributing to scientific knowledge. We hope the information learned from this study will benefit other people with multiple myeloma in the future.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • Eligible patients must have relapsed/refractory multiple myeloma, and be within four weeks of beginning their second (or greater) line of therapy.
  • Patient’s oncologist must be planning to change the patient’s next line of treatment to a monotherapy or combination therapy composed of drugs from the following list:
    • Bortezomib (Velcade)
    • Carfilzomib (Kyprolis)
    • Lenalidomide (Revlimid)
    • Pomalidomide (Pomalyst)
    • Cyclophosphamide (Cytoxan)
    • Dexamethasone
    • Ixazomib (Ninlaro)
    • Venetoclax (Venclexta)
    • Selinexor (Xpovio)
  • Patients must not have had prior CAR-T therapy exposure.
  • Patients must not have had a prior allogeneic transplant.
  • Patients for whom daratumumab or elotuzumab is a component of their next line of therapy may not join this trial.

Additional Trial Information

Observational Trial

Enrollment: 130 patients (estimated)

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Trial Links

Read the latest news and updates on this trial.

Weighing Cancer Cells for Personalized Myeloma Therapy with Clifford Reid, PhD, Travera

October 23, 2019

Can you tell how well a myeloma treatment might work on your personal tumor by weighing the cancer cells? Clifford Reid, PhD and CEO of Travera shares a new approach to “personalized medicine” in multiple myeloma.

Read more

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.


City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting


Dana-Farber Cancer Institute (Main)

Boston, MA

Open and Accepting

Massachusetts General Hospital

Boston, MA

Open and Accepting

New York

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Open and Accepting

Weill Cornell

New York, NY

Open and Accepting
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