Novel 3D Myeloma Organoid to Study Disease Biology and Chemosensitivity


The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidance in the setting of relapsed multiple myeloma and potentially other cancers.

SparkCures ID 1029
Trial Phase Observational Trial
Enrollment 40 Patients
Trial Sponsors
  • Wake Forest University Health Sciences
Trial Collaborators
  • National Cancer Institute (NCI)
NCT Identifier


Am I Eligible?

The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.

The following criteria is provided for health care professionals.

Inclusion Criteria:

  • Any participant who has multiple myeloma with no other ongoing blood cancer and will undergo a bone marrow biopsy as part of their routine care prior to receiving chemotherapy (both newly diagnosed and relapse disease).

Exclusion Criteria:

  • Any participant that does not have multiple myeloma.
  • Any participant with other ongoing blood cancer.

US Trial Locations

Accepting Patients

The following is a listing of trial locations that are open and accepting patients.

North Carolina


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