Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity (Organoid)

What's the purpose of this trial?

The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidance in the setting of relapsed hematologic malignancy and potentially other cancers.

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

  • Patients with suspected or confirmed multiple myeloma undergoing a bone marrow biopsy as part of their care.
  • Patients with smoldering myeloma undergoing bone marrow evaluation for possible transformation are also eligible.
  • The ability to understand and willingness to sign an IRB approved informed consent document.

Exclusion Criteria:

  • They must not have other known active hematologic malignancies or amyloidosis.
  • Any participant that does not have multiple myeloma.

Additional Trial Information

Enrollment: 70 patients (estimated)

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Trial Locations

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North Carolina

Wake Forest Baptist Atrium Health

Winston-Salem, NC

Open and Accepting
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