First-in-human Single Agent Study of SAR442085 in Relapsed or Refractory Multiple Myeloma

What's the purpose of this trial?

Primary Objectives: - Dose Escalation Part A: To determine the maximum tolerated dose (MTD) of SAR442085 administered as a single agent in patients with relapsed or refractory multiple myeloma (RRMM), and determine the recommended Phase 2 dose (RP2D) for the subsequent Expansion Part B - Dose Expansion Part B: To assess the antitumor activity of single agent of SAR442085 at the RP2D in patients with RRMM Secondary Objectives: - To characterize the safety profile of SAR442085 - To characterize the pharmacokinetics (PK) profile of SAR442085 when administered as a single agent - To evaluate the potential immunogenicity of SAR442085 - To assess preliminary evidence of antitumor activity in the Dose Escalation Part A

This trial is currently open and accepting patients.

What will happen during the trial?

Additional Trial Information

Phase 1

Enrollment: 78 patients (estimated)

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Trial Locations

All Trial Locations

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City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting


Dana-Farber Cancer Institute

Boston, MA

Open and Accepting


Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

New York

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Open and Accepting


Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Open and Accepting
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