A total of 17 patients were enrolled and received MCARH109 therapy. The maximum tolerated dose was identified at 150×10⁶ CAR T cells. At the 450×10⁶ CAR T-cell dose, 1 patient had grade 4 cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome (ICANS), and 2 patients had a grade 3 cerebellar disorder of unclear cause. No cerebellar disorder, ICANS of any grade, or cytokine release syndrome of grade 3 or higher occurred in the 12 patients who received doses of 25×10⁶ to 150×10⁶ cells. A response was reported in 71% of the patients in the entire cohort and in 58% of those who received doses of 25×10⁶ to 150×10⁶ cells. The patients who had a response included those who had received previous BCMA therapies; responses were observed in 7 of 10 such patients in the entire cohort and in 3 of 6 such patients who received 25×10⁶ to 150×10⁶ cells.