PVX-410 is a multi-peptide therapeutic cancer vaccine being developed for patients with smoldering multiple myeloma. The goal of treatment with PVX-410 is to induce an immune response against multiple myeloma (MM) cells by "educating" the patient's cytotoxic T lymphocytes (CTLs) to target specific tumor associated antigens. By targeting multiple antigens simultaneously, multiple peptides are employed to target the tumor cell heterogeneity observed in MM, as in all cancers, and decrease the likelihood of tumor cells developing resistance to CTLs. The vaccine is composed of a unique combination of four peptides which specifically target the highly over-expressed tumor antigens XBP1, CD138 and CS1.
PVX-410 has the potential to be utilized as a stand-alone therapy and in combination with other immunotherapeutic drug-like checkpoint inhibitors. In 2013, PVX-410 was granted orphan drug designation from the U.S. Food and Drug Administration for the treatment of multiple myeloma.
View all active clinical trials around the US.
The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment.
The following is a listing of clinical trials for patients with Smoldering Myeloma.