Open-Label, Dose-Escalation Study of INCB054828 in Subjects With Advanced Malignancies FIGHT-101

What's the purpose of this trial?

The purpose of this study will be to evaluate the safety, tolerability, and pharmacological activity of pemigatinib in patients with advanced malignancies.

This trial is currently open and accepting patients.


What will happen during the trial?

 

Additional Trial Information

Phase 1/2

Enrollment: 256 patients (estimated)

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Published Results

Preliminary results from a phase 1/2 study of INCB054828, a highly selective fibroblast growth factor receptor (FGFR) inhibitor, in patients (pts) with advanced malignancies

January 01, 2018

In part 1, no pts had a complete response (CR) or partial response (PR); 9 and 8 pts had stable disease (SD) and progressive disease (PD), respectively. In part 2, most common tumors were cholangiocarcinoma (CCA; n=9), breast (n=8), and esophageal, ovarian, and head and neck (each n=3); 3 pts (with CCA) had a PR (9 mg QD, n=1; 13.5 mg QD, n=2); 9 and 14 pts had SD and PD, respectively.

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Florida

Hematology Oncology Associates of the Treasure Coast

Port St. Lucie, FL

Open and Accepting

New Jersey

John Theurer Cancer Center Hackensack Meridian Health

Hackensack, NJ

Open and Accepting

Texas

Mary Crowley Cancer Research Centers

Dallas, TX

Open and Accepting

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

START South Texas Accelerated Research Therapeutics

San Antonio, TX

Open and Accepting
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