A Phase I Pharmacologic Study of CYC140, a Polo-like Kinase 1 Inhibitor, in Patients With Advanced Leukemias or Myelodysplastic Syndromes CYC140

What's the purpose of this trial?

A Phase I Pharmacologic Study of CYC140, a polo-like kinase 1 inhibitor, in Patients with Advanced Leukemias or Myelodysplastic Syndromes

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Diagnosis of relapsed or refractory advanced leukemias or MDS
* ECOG 0-2
* Adequate renal function
* Adequate liver function
* ≥ 2 weeks from prior chemotherapy, radiation therapy or major surgery
* ≥ 4 weeks from other investigational anticancer therapy
* Agree to practice effective contraception

Exclusion Criteria:

* Known CNS involvement by leukemia
* Currently receiving radiotherapy, biological therapy, or any other investigational agents
* Uncontrolled intercurrent illness
* Pregnant or lactating
* Known to be HIV-positive
* Known active hepatitis B and/ or hepatitis C infection

Additional Trial Information

Phase 1

Enrollment: 50 patients (estimated)

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Trial Locations

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MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting
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