In this study, we seek to improve the efficacy of VCD by adding isatuximab in newly diagnosed multiple myeloma patients undergoing autologous stem cell transplant (ASCT) irrespective of renal function. The primary objective is to determine if the addition of isatuximab to VCD will increase the proportion of subjects achieving very good partial response (VGPR), as defined by the International Myeloma Working Group (IMWG) criteria and by the time of completion of post-ASCT consolidation treatment.
This trial is currently open and accepting patients.
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.
• Hypercalcemia: serum calcium >1 mg/dL higher than the upper limit of normal (ULN) or >11 mg/Dl.
• Anemia: hemoglobin value of >2.0 g/dL below the lower limit of normal, or a hemoglobin value <10.0 g/dL.
Measurable disease as defined (at least one of the following):
Male subjects, even if surgically sterilized (i.e., status postvasectomy), who:
Diagnosed or treated for malignancy other than multiple myeloma, except:
Enrollment: 41 patients (estimated)View More
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