The study is comprised of two parallel Phase 1 Arms (solid tumors and multiple myeloma) and a Phase 1a expansion in patients with TnMUC1+ platinum-resistant ovarian cancer.
The Phase 1 portion of the study is designed to identify the dose and regimen of CART-TnMUC1 cells that can be safely administered intravenously following the lymphodepletion regimen to patients with (1) advanced TnMUC1+ solid tumors or (2) advanced TnMUC1+ multiple myeloma in a parallel two-arm Phase 1 dose escalation study. It is anticipated that approximately 40 patients will enroll in the Phase 1 dose escalation.
The Phase 1a expansion portion of the study is a single arm study designed to assess the preliminary efficacy of CART-TnMUC1 cells administered intravenously following the lymphodepletion regimen to patients with TnMUC1+ platinum-resistant ovarian cancer. It is anticipated that approximately 40 patients will enroll in the Phase 1a expansion.
SparkCures ID | 1034 |
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Trial Phase | Phase 1 |
Enrollment | 80 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Key Exclusion Criteria:
Key Inclusion Criteria:
Key Exclusion Criteria:
The following is a listing of trial locations that are open and accepting patients.
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Los Angeles, CA
Philadelphia, PA
Nashville, TN
Los Angeles, CA
Philadelphia, PA
Nashville, TN
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