The purpose of the UNIVERSAL study is to assess the safety, efficacy, cell kinetics, and immunogenicity of ALLO-715 with or without Nirogacestat in adults with relapsed or refractory multiple myeloma after a lymphodepletion regimen of ALLO-647 in combination with fludarabine and/or cyclophosphamide, or ALLO-647 alone.
SparkCures ID | 1031 |
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Trial Phase | Phase 1 |
Enrollment | 132 Patients |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Inclusion Criteria:
Exclusion Criteria:
Additional Exclusion Criteria for Nirogacestat plus ALLO-715 Cohorts
The following is a listing of trial locations that are open and accepting patients.
New York, NY
Milwaukee, WI
Stanford, CA
Boston, MA
Rochester, MN
Cleveland, OH
Austin, TX
San Antonio, TX
Stanford, CA
Boston, MA
Rochester, MN
New York, NY
Cleveland, OH
Austin, TX
San Antonio, TX
Milwaukee, WI
December 05, 2020
ALLO-715, an off-the-shelf chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA), elicited responses in heavily pretreated patients with relapsed/refractory multiple myeloma in early findings from a first-in-human study presented at the 2020 ASH Meeting.
The therapy generated responses in 6 of 10 patients (60%), including a very good partial-plus response (VGPR+) in 4 patients (40%), who were treated with ALLO-715 at a dose of 320 x 106 CAR cells plus a lymphodepleting regimen that included ALLO-647, an anti-CD52 monoclonal antibody, during the ongoing phase 1 UNIVERSAL study (NCT04093596).
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